The Effect of Administering the Probiotic Lactiplantibacillus Plantarum DAD-13 on Procalcitonin Levels, C-Reactive Protein, and Interleukin-6 in Sepsis Patients in the Intensive Care Unit of H. Adam Malik Hospital, Medan

The Effect of Administering the Probiotic Lactiplantibacillus Plantarum DAD-13 on Procalcitonin Levels, C-Reactive Protein, and Interleukin-6 in Sepsis Patients in the Intensive Care Unit of H. Adam Malik Hospital, Medan | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article The Effect of Administering the Probiotic Lactiplantibacillus Plantarum DAD-13 on Procalcitonin Levels, C-Reactive Protein, and Interleukin-6 in Sepsis Patients in the Intensive Care Unit of H. Adam Malik Hospital, Medan Zulkarnain Zulkarnain, Acshsanuddin Hanafie, Andriamuri Primaputra Lubis, and 1 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-7174498/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Sepsis remains a major global health issue with high morbidity and mortality rates, particularly in intensive care units (ICU). This study investigated the effects of administering the probiotic Lactiplantibacillus plantarum Dad-13 on inflammatory markers (procalcitonin [PCT], C-reactive protein [CRP], interleukin-6 [IL-6]) and defecation profiles in sepsis patients admitted to the ICU at RSUP H. Adam Malik Medan. A randomized, double-blind, placebo-controlled clinical trial was conducted with 30 sepsis patients divided into two groups: one receiving L. plantarum Dad-13 (2 capsules/day for 4 days) and the other a placebo. Biomarker levels and defecation frequency/consistency were monitored.Trial registration: ClinicalTrials.gov Identifier: NCT07072871, registered on 21 July 2025. Retrospectively registered. Results showed a clinical reduction in PCT, CRP, and IL-6 levels in the probiotic group compared to the placebo group, though the changes were not statistically significant (p > 0.05). Defecation frequency and stool consistency improved significantly in the probiotic group by days 3 and 4 (p < 0.05), indicating enhanced gut microbiota balance. The study suggests that L. plantarum Dad-13 may aid in modulating inflammatory responses and improving gastrointestinal function in sepsis patients, albeit further research with longer intervention periods and larger samples is needed to confirm these findings. sepsis probiotics Lactiplantibacillus plantarum DAD-13 inflammatory markers ICU Introduction Sepsis continues to pose a major challenge in modern medicine as a leading cause of multiorgan failure with high morbidity and mortality, especially among critically ill patients. Globally, over 30 million sepsis cases occur annually, with around 5.3 million deaths (Li et al., 2016 ). In Asia, sepsis prevalence in intensive care units (ICUs) is about 22.4%, with variations depending on a country’s income level. One of the key mechanisms that exacerbates sepsis is dysregulation of the host immune response, which contributes to organ dysfunction and disease progression. This immune disruption significantly impacts not only vital organs such as the lungs, kidneys, and heart but also the gastrointestinal system, which often remains clinically unnoticed due to its nonspecific symptoms (Fay et al., 2019 ). Sepsis also induces significant changes in the gut environment and microbiota composition. Within hours of ICU admission, a substantial decline in gut microbial diversity occurs, indicating severe dysbiosis. This dysbiosis compromises intestinal mucosal integrity, increases proinflammatory cytokine production, and facilitates the translocation of toxins that trigger systemic organ injury through the gut-organ axis (Fay et al., 2019 ). Moreover, conventional treatments such as broad-spectrum antibiotics may worsen dysbiosis by disrupting commensal flora and promoting antimicrobial resistance. In this context, probiotic therapy offers a promising alternative as both an immunomodulator and a restorative agent for microbial homeostasis. Probiotics have been shown to inhibit pathogenic colonization, support gut flora, and modulate immune responses through complex mechanisms involving interactions with immune cells (macrophages, T-cells, B-cells) and regulation of cytokine expression (Wischmeyer et al., 2016 ). Studies have reported benefits of probiotics in reducing sepsis-related complications, including findings from Gong et al. ( 2019 ) and meta-analyses demonstrating a reduction in late-onset sepsis incidence. The probiotic strain used is crucial to therapeutic effectiveness. One promising candidate is Lactiplantibacillus plantarum , particularly the Indonesian strain DAD-13, isolated from fermented buffalo milk. This strain is known for its resilience in the digestive tract and demonstrated antibacterial, anti-inflammatory, and immune-boosting properties (Darmastuti et al., 2021 ; Nurliyani et al., 2022 ). Additionally, L. plantarum can inhibit MAPK and NF-κB signaling pathways and reduce TLR4 expression, which are directly related to lowering levels of PCT, CRP, and IL-6 (Tsilika et al., 2021 ; Miri et al., 2022 ). Despite its potential, the use of L. plantarum DAD-13 in adult ICU sepsis patients has not been previously studied. Since probiotic products like Vipilac®—which contain this strain—are approved and widely used in Indonesia, it is important to assess the effect of L. plantarum DAD-13 on inflammatory biomarkers such as IL-6, CRP, and PCT in this clinical setting. Material and Methods This study was a randomized, double-blind, placebo-controlled clinical trial conducted to evaluate the effects of administering Lactiplantibacillus plantarum DAD-13 on inflammatory markers (PCT, CRP, IL-6) in sepsis patients admitted to the ICU of H. Adam Malik General Hospital, Medan. Ethical clearance was obtained from the Health Research Ethics Committee of Universitas Sumatera Utara, and hospital approval was granted. Participants included adult ICU patients (aged 18–65) newly diagnosed with sepsis, using nasogastric tubes (NGT), and receiving enteral feeding of 1500–2000 kcal/day. Exclusion criteria included gastrointestinal disorders, immunocompromised conditions, vascular devices, or probiotic allergies. Participants were randomized into two groups via randomizer.org: the intervention group received L. plantarum DAD-13 capsules (Vipilac®), and the control group received placebo (maltodextrin capsules). The intervention lasted four days, with all patients continuing to receive standard sepsis management as per the Surviving Sepsis Campaign 2021. Blood samples were collected on day 1 (T0) and day 4 (T1) to measure IL-6, CRP, and PCT levels using ELISA. All measurements were conducted in a blinded fashion to ensure objectivity. This trial was designed and reported in accordance with the CONSORT 2010 guidelines for randomized controlled trials (http://www.consort-statement.org). Results This study was conducted and reported in accordance with the CONSORT 2010 guidelines for randomized clinical trials. Thirty ICU sepsis patients were enrolled and randomized equally into the probiotic group (n=15) and placebo group (n=15). Both groups were comparable in demographic and clinical characteristics at baseline, enabling a valid assessment of the intervention’s effects. Karakteristik Kelompok Probiotik (n = 15) Kontrol (n = 15) p value Total (n = 30) Age (year) Mean±SD 48,67±12,1 45,46±11,28 0,461 # 47,06±11,64 Gender (n[%]) Male 11 (73,3%) 6 (40%) 0,065* 17 (56,7%) Female 4 (26,7%) 9 (60%) 13 (43,3%) Weight (kg) 61,18±8,69 55,98±8,79 0,115 # 58,58±8,99 Height (cm) 166±7,57 161,93±7,75 0,157 # 163,96±7,8 BMI (kg/m 2 ) 22,05±1,35 21,18±1,45 0,101 # 21,62±1,45 Albumin (gr/dL) 3,04±0,22 3,0±0,42 0,77 # 3,02±0,33 SOFA Score 5,4±1,88 5,33±1,54 0,272 # 5,37±1,69 Diagnosis (n[%]) Respiratory 10 (66,7%) 7 (46,7%) 0,749* 17 (56,7%) Urogenital 2 (13,3%) 3 (20%) 5 (16,7%) SSTI 2 (13,3%) 3 (20%) 5 (16,7%) Musculoskeletal 1 (6,7%) 1 (6,7%) 2 (6,7%) Nervous system 0 (0%) 1 (6,7%) 1 (3,3%) Mechanical Ventilation 15 (100%) 15 (100%) 1,00* 30 (100%) *Uji Chi Square ; # Uji T Independen In the probiotic group, median PCT levels declined from 3.39 ng/mL to 1.13 ng/mL, CRP from 0.7 mg/L to 0.5 mg/L, and IL-6 from 79.47 pg/mL to 77.92 pg/mL. Though not statistically significant, the decrease in PCT approached significance (p = 0.061), suggesting a potential biological effect. Variabel Periode Pemeriksaan (Median[Min-Max]) p value * T0 T1 IL-6 79,47 (8,66 – 333,23) 77,92 (17,97 – 288,8) 0,91 PCT 3,39 (0,22 – 160,4) 1,13 (0,16 – 128,4) 0,061 CRP 0,7 (0,5 – 14,2) 0,5 (0,5 – 10,8) 0,261 *Uji Wilcoxon In contrast, the placebo group showed clinical increases in IL-6 (from 97.53 to 146.9 pg/mL), PCT (1.32 to 2.5 ng/mL), and CRP (0.7 to 1.4 mg/L), none of which reached statistical significance. Between-group comparisons on day 4 revealed lower biomarker levels in the probiotic group, with p-values of 0.084 (IL-6), 0.174 (PCT), and 0.250 (CRP), indicating a non-significant but favorable trend. Variabel Periode (Median [Min-Max]) p value * T0 T1 IL-6 97,53 (22,06 – 300,36) 146,9 (34,47 – 338,31) 0,156 PCT 1,32 (0,09 – 108,5) 2,5 (0,72 - 106) 0,155 CRP 0,7 (0,5 – 3,02) 1,4 (0,5 – 39,2) 0,062 *Uji Wilcoxon Significant improvements were observed in the probiotic group’s gastrointestinal outcomes. By days 3 and 4, defecation frequency and stool consistency had normalized in most probiotic patients, showing a statistically significant difference compared to controls (p < 0.05). Variabel Probiotic Group Control Group p value * RR (95% CI) n % n % H1 7 46,7 7 46,7 1,00 1,00 (0,51 – 1,95) H2 8 53,3 5 33,3 0,27 0,7 (0,37 – 1,34) H3 13 86,7 5 33,3 0,03 0,2 (0,05 – 0,76) H4 14 93,3 7 46,7 0,04 0,12 (0,02 – 0,88) *Uji Chi Square Time Intervention Defecacy Consistension (n[%]) Total p v alue * Hard Normal Soft H1 Probiotik 3 (42,86%) 3 (42,86%) 1 (14,28%) 7 0,751 Kontrol 2 (28,57%) 2 (28,57%) 3 (42,86%) 7 H2 Probiotik 1 (12,5%) 6 (75%) 1 (12,5%) 8 0,223 Kontrol 0 4 (80%) 1 (20%) 5 H3 Probiotik 0 13 (100) 0 13 0,001 Kontrol 1 (20%) 1 (20%) 3 (60%) 5 H4 Probiotik 0 14 (100%) 0 14 0,014 Kontrol 2 (28,57%) 3 (42,86%) 2 (28,57%) 7 *Uji Mann-Whitney This suggests beneficial modulation of gut microbiota, often impaired in sepsis patients due to critical illness and antibiotic use. Discussion This study aimed to evaluate the effect of administering the probiotic Lactiplantibacillus plantarum DAD-13 on inflammatory biomarkers—namely IL-6, CRP, and PCT—in sepsis patients admitted to the intensive care unit. Although no statistically significant differences were found, the results demonstrated a downward trend in inflammatory biomarkers in the probiotic group compared to the placebo group. The most notable decrease occurred in PCT levels, with a p-value of 0.061, indicating potential clinical significance despite not reaching conventional statistical thresholds. PCT is a specific biomarker for systemic infection and is widely used for diagnosing and evaluating therapeutic response in sepsis. The sharper decline in PCT levels in the probiotic group suggests a potential improvement in systemic inflammatory response due to the immunomodulatory effects of the probiotic. This aligns with findings from Miri et al. ( 2022 ), which showed that L. plantarum administration suppressed proinflammatory cytokines, including IL-6 and TNF-α, by inhibiting the TLR4/NF-κB pathway. The concurrent reductions in IL-6 and CRP levels observed in this study further support the hypothesis that probiotics act through modulation of the innate immune system. This effect may be reinforced by the fact that L. plantarum DAD-13 is a locally derived strain that has demonstrated strong resilience in the gastrointestinal tract, along with antibacterial and anti-inflammatory properties. Several preclinical studies have shown that this strain enhances IgA production, reduces pathogenic colonization (such as Escherichia coli ), and improves the condition of intestinal mucosa (Darmastuti et al., 2021 ; Nurliyani et al., 2022 ). These findings suggest that L. plantarum DAD-13 not only modulates systemic immune responses but also restores gastrointestinal integrity disrupted by sepsis and intensive antibiotic therapy. Intestinal microbiota imbalance (dysbiosis) is a key factor in the pathogenesis of sepsis through the gut-organ axis. In sepsis, increased mucosal permeability facilitates endotoxin and microbial translocation into systemic circulation, exacerbating inflammation and leading to multiorgan dysfunction. Probiotics help restore intestinal eubiosis and prevent further barrier damage, thereby reducing systemic inflammatory stimuli (Fay et al., 2019 ). This study also noted improvements in defecation frequency and quality in the probiotic group, which can serve as indirect indicators of gastrointestinal function recovery. This is significant because gut function is often overlooked in sepsis management, despite its central role in numerous immunological and metabolic pathways. The probiotic’s role in improving gut function reinforces its potential as a complementary therapy in an integrative approach to sepsis. Nonetheless, several limitations must be considered. The short intervention duration (4 days), small sample size, and concurrent treatments such as broad-spectrum antibiotics and opioids—which may affect gut microbiota—are factors that could influence the observed effects and limit the detection of statistically significant differences. Further research with larger sample sizes, extended intervention periods, and better control of confounding variables is needed to validate these findings and explore the underlying molecular mechanisms. Considering all these findings, L. plantarum DAD-13 may be considered a supportive intervention in sepsis management, particularly in helping regulate systemic inflammation and maintain gastrointestinal function in ICU patients. This study provides an important early contribution to the development of locally sourced, microbiome-based therapies that are safe and potentially beneficial for critically ill patients. Conclusion Administering Lactiplantibacillus plantarum DAD-13 to ICU sepsis patients resulted in decreased levels of IL-6, PCT, and CRP, with notable clinical improvement in gastrointestinal function. While statistical significance was not achieved, the trends suggest that L. plantarum DAD-13 has potential as an adjunct immunomodulatory therapy for sepsis. These findings support the safety and tolerability of probiotic interventions in critical care and highlight the need for further studies exploring local probiotic strains in severe illness contexts. Abbreviations ICU : Intensive Care Unit PCT : Procalcitonin IL-6 : Interleukin-6 CRP : C-Reactive Protein Declarations ETHICS APPROVAL AND CONSENT TO PARTICIPATE This study was conducted in accordance with the ethical principles of the Declaration of Helsinki. Inform consent was obtained from all the participants. CONSENT FOR PUBLICATION Not applicable. AVAILABILITY OF DATA AND MATERIALS Data supporting the conclusions of this study are included in the article and its additional files. COMPETING INTEREST The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. FUNDING The authors would like to thank PT Royal Medicalink Pharmalab for funding this study. AUTHOR’S CONTRIBUTIONS Z wrote the main manuscript AH wrote the main manuscript APL wrote the main manuscript YY wrote the main manuscript All authors reviewed the manuscript ACKNOWLEDGEMENTS The authors would like to thank PT Royal Medicalink Pharmalab for funding this study. The authors also would like to thank all the participants who participated in this study. REPORTING GUIDELINES This manuscript adheres to the CONSORT 2010 checklist for reporting randomized controlled trials. References Dang, A. T., & Marsland, B. J. (2019). Microbes, metabolites, and the gut–lung axis. Mucosal Immunology , 12(4), 843–850. Darmastuti, N., et al. (2021). Efektivitas Lactiplantibacillus plantarum DAD-13 dalam menurunkan jumlah koloni Escherichia coli di kolon pada tikus. Laporan Penelitian , Universitas Gadjah Mada. Fay, K. T., Ford, M. L., Coopersmith, C. M. (2019). The intestinal microenvironment in sepsis. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease , 1865(5), 1129–1135. Gong, J., et al. (2019). Effects of probiotics on liver injury induced by sepsis in murine models. Journal of Hepatology Research , 4(2), 34–42. Kim, S. K., et al. (2017). Immunomodulatory effects of Lactobacillus plantarum lysates on lipopolysaccharide-stimulated macrophages via MAPK and NF-κB signaling pathways. Nutrition Research and Practice , 11(2), 97–104. Li, Y., et al. (2016). The epidemiology of sepsis in intensive care units in Asia. Critical Care Medicine , 44(8), e377–e386. Miri, H., et al. (2022). Lactobacillus plantarum from fermented soy suppresses inflammation in septic rats. Nutrition Research , 102, 35–45. Nurliyani, N., et al. (2022). Kombinasi probiotik L. plantarum DAD-13 dan serat ubi jalar meningkatkan kadar IgA di saluran cerna tikus. Jurnal Ilmu Ternak , 22(1), 34–42. Tsilika, M., et al. (2021). Early administration of probiotics in ICU patients reduces incidence of ventilator-associated pneumonia and sepsis. Clinical Nutrition , 40(2), 507–515. Wischmeyer, P. E., et al. (2016). Role of the microbiome, probiotics, and ‘dysbiosis therapy’ in critical illness. Current Opinion in Critical Care , 22(4), 347–353. Additional Declarations No competing interests reported. Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. 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Adam Malik Hospital, Medan\u003c/strong\u003e\u003c/p\u003e","fulltext":[{"header":"Introduction","content":"\u003cp\u003eSepsis continues to pose a major challenge in modern medicine as a leading cause of multiorgan failure with high morbidity and mortality, especially among critically ill patients. Globally, over 30\u0026nbsp;million sepsis cases occur annually, with around 5.3\u0026nbsp;million deaths (Li et al., \u003cspan citationid=\"CR6\" class=\"CitationRef\"\u003e2016\u003c/span\u003e). In Asia, sepsis prevalence in intensive care units (ICUs) is about 22.4%, with variations depending on a country\u0026rsquo;s income level. One of the key mechanisms that exacerbates sepsis is dysregulation of the host immune response, which contributes to organ dysfunction and disease progression. This immune disruption significantly impacts not only vital organs such as the lungs, kidneys, and heart but also the gastrointestinal system, which often remains clinically unnoticed due to its nonspecific symptoms (Fay et al., \u003cspan citationid=\"CR3\" class=\"CitationRef\"\u003e2019\u003c/span\u003e).\u003c/p\u003e\u003cp\u003eSepsis also induces significant changes in the gut environment and microbiota composition. Within hours of ICU admission, a substantial decline in gut microbial diversity occurs, indicating severe dysbiosis. This dysbiosis compromises intestinal mucosal integrity, increases proinflammatory cytokine production, and facilitates the translocation of toxins that trigger systemic organ injury through the gut-organ axis (Fay et al., \u003cspan citationid=\"CR3\" class=\"CitationRef\"\u003e2019\u003c/span\u003e). Moreover, conventional treatments such as broad-spectrum antibiotics may worsen dysbiosis by disrupting commensal flora and promoting antimicrobial resistance.\u003c/p\u003e\u003cp\u003eIn this context, probiotic therapy offers a promising alternative as both an immunomodulator and a restorative agent for microbial homeostasis. Probiotics have been shown to inhibit pathogenic colonization, support gut flora, and modulate immune responses through complex mechanisms involving interactions with immune cells (macrophages, T-cells, B-cells) and regulation of cytokine expression (Wischmeyer et al., \u003cspan citationid=\"CR10\" class=\"CitationRef\"\u003e2016\u003c/span\u003e). Studies have reported benefits of probiotics in reducing sepsis-related complications, including findings from Gong et al. (\u003cspan citationid=\"CR4\" class=\"CitationRef\"\u003e2019\u003c/span\u003e) and meta-analyses demonstrating a reduction in late-onset sepsis incidence.\u003c/p\u003e\u003cp\u003eThe probiotic strain used is crucial to therapeutic effectiveness. One promising candidate is \u003cem\u003eLactiplantibacillus plantarum\u003c/em\u003e, particularly the Indonesian strain DAD-13, isolated from fermented buffalo milk. This strain is known for its resilience in the digestive tract and demonstrated antibacterial, anti-inflammatory, and immune-boosting properties (Darmastuti et al., \u003cspan citationid=\"CR2\" class=\"CitationRef\"\u003e2021\u003c/span\u003e; Nurliyani et al., \u003cspan citationid=\"CR8\" class=\"CitationRef\"\u003e2022\u003c/span\u003e). Additionally, \u003cem\u003eL. plantarum\u003c/em\u003e can inhibit MAPK and NF-κB signaling pathways and reduce TLR4 expression, which are directly related to lowering levels of PCT, CRP, and IL-6 (Tsilika et al., \u003cspan citationid=\"CR9\" class=\"CitationRef\"\u003e2021\u003c/span\u003e; Miri et al., \u003cspan citationid=\"CR7\" class=\"CitationRef\"\u003e2022\u003c/span\u003e).\u003c/p\u003e\u003cp\u003eDespite its potential, the use of \u003cem\u003eL. plantarum\u003c/em\u003e DAD-13 in adult ICU sepsis patients has not been previously studied. Since probiotic products like Vipilac\u0026reg;\u0026mdash;which contain this strain\u0026mdash;are approved and widely used in Indonesia, it is important to assess the effect of \u003cem\u003eL. plantarum\u003c/em\u003e DAD-13 on inflammatory biomarkers such as IL-6, CRP, and PCT in this clinical setting.\u003c/p\u003e"},{"header":"Material and Methods","content":"\u003cp\u003eThis study was a randomized, double-blind, placebo-controlled clinical trial conducted to evaluate the effects of administering \u003cem\u003eLactiplantibacillus plantarum\u003c/em\u003e DAD-13 on inflammatory markers (PCT, CRP, IL-6) in sepsis patients admitted to the ICU of H. Adam Malik General Hospital, Medan. Ethical clearance was obtained from the Health Research Ethics Committee of Universitas Sumatera Utara, and hospital approval was granted.\u003c/p\u003e\n\u003cp\u003eParticipants included adult ICU patients (aged 18\u0026ndash;65) newly diagnosed with sepsis, using nasogastric tubes (NGT), and receiving enteral feeding of 1500\u0026ndash;2000 kcal/day. Exclusion criteria included gastrointestinal disorders, immunocompromised conditions, vascular devices, or probiotic allergies.\u003c/p\u003e\n\u003cp\u003eParticipants were randomized into two groups via randomizer.org: the intervention group received \u003cem\u003eL. plantarum\u003c/em\u003e DAD-13 capsules (Vipilac\u0026reg;), and the control group received placebo (maltodextrin capsules). The intervention lasted four days, with all patients continuing to receive standard sepsis management as per the Surviving Sepsis Campaign 2021.\u003c/p\u003e\n\u003cp\u003eBlood samples were collected on day 1 (T0) and day 4 (T1) to measure IL-6, CRP, and PCT levels using ELISA. All measurements were conducted in a blinded fashion to ensure objectivity. This trial was designed and reported in accordance with the CONSORT 2010 guidelines for randomized controlled trials (http://www.consort-statement.org).\u0026nbsp;\u003c/p\u003e"},{"header":"Results","content":"\u003cp\u003eThis study was conducted and reported in accordance with the CONSORT 2010 guidelines for randomized clinical trials.\u003c/p\u003e\n\u003cp\u003e\u003cimg 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KXW55ZZL1itWXXXVcrpGnltttVXpZ9qFkbj11lsTXl3tfdpppyXGbaGFFkq+74DXTIPxl8PkJ0PiinN8MGz8XfXNSFo3gYcL9eadd96kXHiRPkXtKTwyZeTqbjfFCsuAuR6cgRCuNrw4may3/OMf/yivLIfpDjvsUF5Rzmjwh4ULABlqOJkmUy9w/8Y3vpGTiec4ITDFOOUb2fYpApTENddck9xIavqDkqXILrzwwlRduHTjKOX48MMPl4vAFk5BlqcpKFCKSi+fkmIQjBwuv/zy8qM8M8wwQ3m9dlEUya2r0imKIu01afpE3tIyJWOkQjH6xgJFxXgwNhTVGWeckaabbrrkQzjXXnttohR//OMfJ99cEHa99dYrb4uV1nBJ/Nlnnz2ZurFoLS1K9IILLkj83XzqufLKKyfGsLYXPRh/PohU5QO+iy22WMJr9oe9splykv9OO+2UGF9k/WLZZZfNQQeebmv1HQlrGabI3OZ6/vnnl+sa9cIPRJz0g5Fzm+ykn3X/e7f99tsnBsgCtDLoLBhdmb6qvMX+ugAAEABJREFUGymFb7sQCAPRLqQjnxIBxsBOl1/+8pdJT/bAAw9MdrfoNeuRloEm/dHD1XNlBM4666xEqU3yTnbkeOpdHn300WmBBRZIFKywlIsnJWp3kZ45Q2Oqx5y3/PR2XXUtDXlfdtll5Q4bPXjXgTM2d9xxR9mbl5YeOB4++MEPlgbClEs2MNJgZDyHS1dccUUyWmHoxJlxxhnLkdA999xTTsGkSf/kgSb9fN3/wfhT/tdFqPGYf/75k4Vr026MNcVsRDbcRWwjsA996EPlukrVoNdkM2wnzBkZI5kTTjihHDnBH5+5zoedWARsOgJhIJoOaSQ4GAJ64nqGe++9d/JVNlMOu+66azLdYG48x9XzNKVBqf/hD39IPkbDkLzrXe8qe/AMiCkkPeAcxzcTTFllomSMDvTWTRP54pkpn5/+9KdlFFMaRhTWOMyN22XkBeXsC2g5HR+/8X0DChExcsKNhsQ3MjLXLn5RvDrCkSdlyW8oErYef8OJDz/TbUcccURi9PTWYWM0MVS+1fd4GE5+1TiNfhuhbDhpIftHP/pRYsjxZIdYo/Dh3z4EwkC0D+t+yalhOfV+KQHTJhYhM9k3zyD4SpswEjCiMI1EiTEGevpGGMcee2wSxo4gowjTQObuGQPxzeE//fTTyQK0KSHvrBfosVOq5v6teZhSsRhqCsniK7JAzG16yuKrkYi0bFW966670oQJE8rRDl4oeqQXjvzGdy2Z2tKzR94xRtLTc+enLIzYIossUo6SpJNJ+FoajD9hxZUunrg9+Xly48ci/Q9/+MNy8ZyxVA/ieC+s3zk8P7+NpPyGiR6+etHDrw0vLD9P4ZHfyO9Mwjgjwr8oigQXo5jPf/7zybShcuaw8Rw/BMJAjB/2fZWzeXwK3fy+6RyKEQAUhHMBeuVGEKZzvLeou88++yTTDuLo7VMaFqWlY+H5lFNOKRey3/nOd6Ytttgi6YmuuOKK6Ytf/GK5YG1RmLKzi2j//fdPv/3tb8uF4Y985COJEeC2GP6b3/ym7Ll++tOfLv3t6JG+NQYjHAbB6ER6RhOHHnpospbwxz/+MeGb8jRFpCzKlMnIhwJmrJSDsZGHr77pwdupxOCZsjLNItzpp5+eLIibhjNiymnlJ74b8eegHCNnIZqBlZ88HJpzWO/JJ59MlDID6fCbdR2fAbWbDPZGNjm+NSH5m46C+zHHHJOkpdxLLbVU+bnUan45vDA5P5gwhNaFkN+MyjzzzJMuuuiikhgcZTNVZyRZFEUyJcgvaPwRCAMx/nXQFxwwCJTsXpMWifUeszKlwCkiUwwWQClPO2649VL19M15W08w/73aaquVC7zWHfQ07b6hxPSCjU4YFTtiKD1rDdYgjFAoYWkZKTAgRhS2cwpDyVOUpqAsaFOedjJxU1ZGHRZ8VZR1C9Naev387MaxyOrMQO2Ui/xM52y33XbJO+VmzOyycrhMb95OLOlZi6DQTYdZMGfsMkbyzTQYfwyVBW7xLSTLL5cT9rAuiiIxMKbuGFV4wI+CN0LL8XP+ymW0AWsGhHFVXkajml8OX81PnTNIDC3yW17yVUdGDNLPZbMOYQRR9cvv4tkmBGqyCQNRA0g4W4OAdQdKftttty2nEyhuOVG0eqT80dZbb13OjduRRJFYB9BrzztxGI2NN944CcuIVOfOKVvTV5SyOWxKmcLSO5eWOKYyKDd5m3Lacssty7UQitK8On+86V1bI2E4qgqLUfjkJz+ZGA18S88zpyl+psynfJHF6aIoykNodgXxW2uttcpRizim2fghi+wMIv9aasQfJS1uJvnl357cpuHsEMp4MF4wZkCr8XP+DJIdT7ksK04aockfT/XCyyeT9Y6ll166rCt+fhdFkXQC1BM+pJPJxgWYZ3c8xx+BMBDjXwfBQSDQNgRsBrD2YirIdJ3pJlNlRmD1jFyrGbMo7cwDg2T0ZBTR6jwj/eEjEAZi+FhFyAYI6EmiBq/Du2kIjD0hi+8UsoV7U0XWC4wKjBLGnvrIUzBKss3WiM2oYqgUjPKMQIYKF++bg0AYiObg2NepONyF+hqELik8Q27h3XQOY2GtZjwVrjUgC9+mFvPU1WBQzjDDDMm03GBh4l3zEAgD0TwsI6VAIBAIBHoKgTAQzavOSCkQCAQCgZ5CIAxET1Vn9xXGdRbOSHQq5w7rua/JFs1O5dH5BhjW2xbbiTzb/urgoW2ynchf8PQaAmEgXsMifo0DAg5PuX5jHLIeMkuXx9nt45yGMwRDRhhjAMbI9SGuwj7ggANed8Ot5PN7X45zjoIfResgmnueuDudnGFx7sK5j47hNRipi0AYiLqwhGe/I0B5Wcx1xsHJX+cpWo2JE91GAm5VdfLZuZFqnoyGb2c40W17KEPivbMgDt5553p0fkGBQDMQCAPRDBQjjZ5CwGiBsnZ4zG2xCmf6Rg/fKW89dqeOncB2Wtn7sZJTyg6OObTGMCE3ruZ0ffDHR5CcunYK2dPHgIwohHGAj0FxShpf/IICgbEiEAZirAhG/DYg0N4sTC25C8n5gJyzL6NR3q6CcM+Rk8hOPjtolsPkp3UV/qeeemqqR5S9efgc3tNp7cUXX7z8KJG7qdzL5JSzd+iiiy4qr+twSSG3UQYD5u4kbuSUuac7oDyDAoGxIhAGYqwIRvyeQ8B10z6/WT0f4PyAXr4F4QkTJpRfraOgGYtaAKxZUPLSqEfuaGo08nBRn+s/XI6XRy/Sx5OpLr8z4aM6yuCPZx8f6uRFdXwGdQcCYSC6o56CyzYiQKm7x8mp3ZytA1rm+hkKPX3K2f1SFodzmPx0+MsIw4V49cjlgU4Q5/DVp096Gqk4XWwaqbqmUOWnGqf6W3y7riwEV/3jdyAwGgSaYSBGk2/ECQQ6FgFrDEVRpKIoXsejywWrnkYUVbffdui4LJBBqUcuADSKELaWGCKXCFpwlpcTz8L4XTvqMEpwmZ73mSymC4eyXzwDgdEiEAZitMhFvJ5FwJUPjMRolawdRaZ+fC+hHlnfyLfTNgLRmoTbT41UhFl55ZWTLcF5ZMAwXXrppclNt95nYjQYk1rDkd/HMxAYCQJhIEaCVoTtCwQoZVNM1d1AFpWdO/AxHr8BYVeTHU/ZzW+05GZV39hmBOyU8gEfSt7V4tJkdHx1zrcZ7KCye8k3JKxXeJ9p4sSJyedRXe2d/QZ9xstAYBAEwkAMAk686k8EfMcAWRjOCPiOwsUXX5zsQNpxxx2THUa2mZrv585fRsvhR/pkZH7xi18kBsEahbx8Oc+agrRmm222dPjhhycjE7urzjnnnHTIIYek/F4YxMAYbfhyG3dQIDAWBMJAjAW9iNuTCOiZ+z6BKRznHxTSp0l939qogaL29TvTPRQ7ty+4CTdaskOJUfC9Z99n2G233ZIPIFXTs632uOOOS06ee7oiu/r++uuvT76nYA2j6h+/A4HRIhAGYrTItSVeZDJeCKyzzjrlIvV5552XzOuPFx/DzddaxymnnJKOOuqoNO200w43WoQLBAZFIAzEoPDEy35FYKqppkq77rprMnV00003dbSRsFbiwz8bbLBBcho7xb9AoEkIhIFoEpCRzOgQ8O3pfDp4dCm0LpZpo/XWWy8572BnUOtyGlvKzlQsssgiydbasaXUntim8HzLezw+cdqeEr6aSy/8DQPRC7XYxWWw28a8eacWwWIv/ori9WciOoVnZx/gWBSdy2MVK7uzGIlONrpVfvv5dxiIfq79KHsgEAgEAoMgEAZiEHDiVQ8jEEULBAKBIREIAzEkRBEgEAgEAoH+RCAMRH/We5Q6EAgEAoEhEehQAzEk3xEgEAgEAoFAoMUIhIFoMcCRfCAQCAQC3YpAGIhurbngOxDoUASCrd5BIAxE79RllCQQCAQCgaYiEAaiqXBGYs1E4K677kq///3vB8jNqajqJ4xPgbrgLvu7tM53od14mv1uvvnm8nvP2e3pSm2X7bkkjxv5XCe/K6+8ciBfl/a5qM87YZA4wkmXO5OrOap+eMCLb0z7VnQO59pwvGe3p7K5DNDvTD5BKm88ZD+8yadaZhf4uTNKmXI4T37e+Y3EcZ04jLgRPxjKizsTXvCU3Z54xrvfSJmUTRmVlR+CAR79zsSvmfIRabUegTAQrce4s3LoIm5cXX3EEUekTLfeemtC2e0pzD333JOOPfbYgXAU+cSJE9PPf/7zAb/LL7+8vE9JnEynnnpqogR/+9vfDoTzJbenn366NA45nA/8+BaEd9lPHHFd/539PClPefmN8IAXyvcnP/nJQD6UJd6FyaRsvvWQ3Z7nn39+kjceuBGFKx/fj+BGZ599dmKwlIk7Ez/vslscihtG2Q92MJRX9vPEC578zoRnvGe3MimbMipr9ocBHrPbE1ZdJH7B6iQEwkBMAiH+dyYCPpLjdtJM7m1C2e0pjDuIDj744PImU36bb755+sAHPpB+8IMfDPitu+66yZUU3mdyGZ9rNPbee++BcAceeGB5ZfYOO+ww4LfHHnukOeaYI3mX44ojri+6ZT/P9773vUlefiM84GXVVVctjQM/tOyyyya8+51J2XxJLrs9t9hiizJvPHAjvMnne9/73gCP22yzTfIlPGUSJhM/77JbnNlnnz3BKPvBDobyyn6eeMGT35nwjPfspviVTRmVNfvDAI/Z7QmrzpS04KoRAmEgGiET/uOOgGurfSgnE2WHsttTmCmnnDLNMsssiRtNP/30aaqppkqzzjpr4kaUeVEUA25+7gPy5Tif/+RGfrsjyEV93IiiZFy840Z+iytd7kx4qfrhYapJvOAzh/FUjnp+8vY+k29UyxsP2Q9v8qmW2bev8aNMOZwnP+/8RuK4CwlG3Iif9OTFnQkv+MxuTzzX81NGZRUGwUCafmfiN+5C1d0MtJ37MBBthzwyDAQCgUCgOxAIA9Ed9RRcBgKBQCDQdgTCQLQd8siwVxGIcgUCvYZAGIheq9EoTyAQCAQCTUIgDESTgIxkAoFAIBDoNQT6x0D0Ws1FeQKBQCAQaDECYSBaDHAkHwgEAoFAtyIQBqJbay74DgTqIOBqjVdeeaXOm672CubHCYEwEOMEfGQbCLQCgcMPPzzddtttrUg60uxDBMJA9GGlR5EDgUAgEBgOAmEghoNShBkUgXgZCAQCvYlAGIjerNcoVSAQCAQCY0YgDMSYIYwEAoFAIBDoVgQG5zsMxOD4xNtAIBAIBPoWgTAQfVv1UfBAIBAIBAZHIAzE4PjE20BgPBGIvAOBcUUgDMS4wh+ZBwKBQCDQuQiEgejcugnOAoFAIBAYVwTCQIwB/ogaCAQCgUAvIxAGopdrN8oWCAQCgcAYEAgDMQbwImogEAh0KwLB93AQCAMxHJQiTCDQJQgss8wyaaaZZuoSboPNTkcgDESn11DwFwiMAIHFF188vf3tbx9BjAgaCDRGIAxEY2zizfghEDkHAoFAByAQBqIDKiFYCAQCgUCgE0YHrzsAABAASURBVBEIA9GJtRI8BQKBQCDQAQiMykB0AN/BQiAQCAQCgUCLEQgD0WKAI/lAIBAIBLoVgTAQ3VpzwXcgMAmBF198Md1www3p/PPPL+m+++5Lzz//fLruuusG3JOCVf7Hz0Bg+AiEgRg+VhEyEOg4BF566aXSEGy44YZp9913Tw888EB64YUX0kUXXZR23XXX0t1xTAdDXYNAGIiuqapgNBB4PQJTTjll2mijjdJKK62UFlxwwbToooumaaedNs0111xpn332Kd2vjxU+gcDwEAgDMTyc2hUq8gkERozAjDPOmDbbbLN02mmnpbvuuis999xz6eGHH05LLrnkiNOKCIFAFYEwEFU04ncg0KUILL300mm++eZL++67b7r++uvTrLPOmt7ylrd0aWmC7U5BIAxEp9RE8BEIjAGBGWaYIX31q19Np556arkmMcccc6Q3v/nNY0gxoo4YgR6MEAaiBys1itSfCKyxxhppwoQJ6fbbb0/vec97+hOEKHVTEQgD0VQ4I7FAYPwQmGaaadKee+6Z1l9//ZheGr9q6Kmcw0D0VHVGYRoj0B9v1l577bT66qv3R2GjlC1HIAxEyyGODAKBQCAQ6E4EwkB0Z70F14FAIBAItByBTjEQLS9oZBAIBAKBQCAwMgTCQIwMrwgdCAQCgUDfIBAGom+qOgoaCLQIgUi2ZxEIA9GzVRsFCwQCgUBgbAiEgRgbfhE7EAgEAoGeRSAMRM9WbS5YPAOBQCAQGB0CYSBGh1vECgQCgUCg5xEIA9HzVRwFDAQCgW5FYLz5DgMx3jUQ+QcCgUAg0KEIhIHo0IoJtgKBQCAQGG8EwkCMdw1E/g0RuOaaa8rPZvp0JrrxxhsT8juTMP/85z/ToYceOhD2jDPOKK+8/s53vjPgd8EFF6QXX3xxwC3+Mccck5566ql05JFHDvj/4Ac/KP2OO+64Ab+f/exn6cEHH0zeiYfEeWpS3PPPP38gHP+77747yctvhAfXb//lL39J+++//0BYH/XBuzCZlO2xxx4bCMP/9NNPL/PGAzfCm3y+973vDYQ9+eSTyy/JKZMwmXxdzrvsFueRRx5JMMp+sIOhvLKfJ17w5HcmPOM9u5VJ2ZRRWbM/DPCY3Z6waljZ8aIjEQgD0ZHVEkxB4PHHH0/33nvvAD3xxBMJVf2EefbZZ9N99903EI4CpPirfo8++mh65ZVXBsJI44EHHkgvvfRS+ve//z3g/69//as0JP/5z38G/Lx//vnnk3fiIX7iyos7k3zlld144Pff//53ID3v+OHd70zKJs3s9nzooYeSvOXHjfAm/v333z+QJgP28ssvJ2USJhM/77JbHHhV+cYjP3nlcJ54wZPfmfAs7+z2VDZ+0uFGMODndyZ5qteg7kEgDET31FXfcbrSSiulH//4xwO0xBJLJFT1E2bBBRdMBx100EC4TTbZJC288MLpkEMOGfBbd91105ve9KYBtzR22WWX9Na3vjV985vfHPD/9re/naaffvq0/fbbD/jtvvvu6Z3vfGfyTjwkjri+vcCdaYEFFkjyym484OVjH/tY+uEPfziQpk+E4j2H81Q235f2O9Pmm29e5o2H7Ic3+eixZ7+tt946TT311EmZsp8nP+/8RuK84x3vSDDiRrCDoby4M+EFT9ntiWe8+42USdmUUVn5IRjg0e9MsErxr6sQ6GED0VX1EMzWQaAoilQUQ5OoRTF5uE73K4rJ+S2KV939wLcyBnUHAmEguqOegstAIBAIBNqOQBiItkMeGQYCgcBQCMT7zkAgDERn1ENwEQgEAoFAxyEQBqLjqiQYCgQCgUCgMxAIA9EZ9dBdXAS3gUAg0BcIhIHoi2qOQgYCgUAgMHIEwkCMHLOIEQgEAoFAtyIwIr7DQIwIrghci8ALL7xQnmKu9e9Et1PAt956a7rttttawt6TTz6ZrrrqqvTMM880Lf2nn346uQbDVRZONg+WsBPWzcx7sLxG+04doNHGF88VIMjvoNYiEAaitfj2fOquTzj++ONHXM4rrrgiOdXrdHKVTjnllOQ6iBEnOIwId955Z9puu+3KE9HDCD7iIDfddFNaa6210j333DPiuI0i3HXXXeUdUHvvvXdigOqFYzj+/Oc/p7///e/lVST1wjTbD18///nP04EHHpjc4eRKjmoe6vAXv/hFWceXXHJJeV2I964M+eMf/zimTgUjjKQX1FoEwkC0Ft9IvQECs80228AVEhdddFFabLHF0iyzzFIqlF133TVNnDixQczRe88///wNlezoU30t5nvf+97EWLqW4zXfkf2qDT377LOnqaaaakDB1r7n/utf/1qOXBZddNESQ36tJEr+nHPOSe5vcj/Vbrvtlk477bTyXiv5untp3333TToP73rXu9Lhhx+ehHcvFPess86aTj311JbWBT6Cxo5AGIixYxgpjAKBueeeO2244YZpoYUWSnPMMUdyn88WW2xR9u5//etfpz/96U+jSHXwKBTtG9/4xsEDjeGtu5lWWGGFNM0004whlcmj4vkNb3jD5J4Vlwvx3Mw677zzphlmmKHypnU/TWOtvPLKyR1P++23X1p11VXTzTffXF5y6Mbc3/72t+UlgptttllaZ5110pprrlnemGtaSFl0BtwIe95557WOyUi5KQiEgWgKjJHIaBAoiiK9/e1vH4haFEWaeeaZS7dbSa1vuIH1uuuuSy6S+/CHP5wWWWSR9PWvfz25LdTto6an1ltvveRK60996lNprrnmKpURRSUh6w0U2Yorrpg+/vGPJ2sQ/JGrsH/zm9+kDTbYoLwE8BOf+ETZE+Yv/29961vlpX8UnjSMEFyXfeWVV6YvfelL6d3vfnfacccdy2u2hTfl8sEPfnAgj2233TYtueSSadllly1HSAyHy+9MQVkvkNZHPvKR8p3L+MzNK6/pmz322KOMt/rqqye9c/zWIyOtq6++Or3nPe8pX8Ps97//fZmma7jh8/73vz9ttNFGSfploMofeZmeakTKVQle/pxnnnnSfPPNl+TlBleXIC611FLlZYgM1uWXX17mP91005XhJ0yYUK77mHbiwejlC/9gzS+oMxEIAzGSeomwLUPAldaUN6VJoVCkFA9F/4c//KHslZum8B0GPU/fKTAamHbaacs5/6Io0gEHHFAqwjPPPDPprbqG2nSVaQ1Kk7I0zZELIb1DDz20jHfhhRemlVZaKVHqlCUlprdruuQtb3lL+v73v5922mmn8psODz/8cHl77MEHH5yMdv7xj3+U00AzzDBDMv2S0994442T6bPLLrssWUOgqN1+ygj+5Cc/KaeDfve73yXpnHXWWcn3EvTOvWMojAwYnTnnnDMn+brn2WefnaaYYork5lUv/X7zm9+cLG7fcMMNZe/dzbOMGkyEqZKeP2wa0V2T1kCq4au/1RVDaQGd8SyKopx2kqapMfUnvNtxja74cyNGhmG75ZZbOIM6FIEwEB1aMf3EFoWvd7/hpCknyvewww4re/QwoKT18L/yla+kv/3tb8nHch577LFSAc4wSSGbnqIcl1lmmbJXax5eGua/KWaL4UYWerNGH4yFdBGDoidreoahMUpwPbZFV0rN6IayFWfKKadMRgeMkt6z9FybrRfNKAhfq8gZOelRoAzbzjvvXJbLCIIx8BEgo5+99tqrNHLnnntuOTJiVFZZZZVS6VO0+MZvPTIVBwf5ew8vfBmtMHiMkrUXCrqeMjY9xHA2ImWQbj0yMjKldscdd5RXmVcX0eFWFEW9aKWfdQhYmmoqPeJPRyIQBqIjq6W/mDLNkpWkHj6lQ7FCQY9YD96Xy7773e8mc98UuneZiqIorwXPbqMR5ItmFJVpp/yOUsq/LbDaAZTdjATlWm8qJocZ6dOIwPcQGJk11lijjG5aBU+//OUvyx1ARjKmaowuGBzvGb0y8KQ/lP6kR93/jKWeOqoNUC2rd0ZUnlUylWW01IgYsWr46u/ll18+mRr7xje+kU466aRy1FZ9P9hvvBVFURr6wcI18V0kNQoEwkCMArSI0jwETCFRgNYXfvrTn6Zrr702GS3olZtmoWBtpdSbp1DNdRdFMSwGGAc7bUxd1Yvwtre9LZmqEia/L4qinPrJ7rE+bds11WN0oldvjp5RwpNtqUYmiN/FF19cGjojIPP1yj9U/owno4KGClvvvd1Gyt+IvvCFL9SLNuDHgBuhGImpRyOr5ZZbrtxyq+6UYeLEiYlxsh6TI/L3Wx15BnUmAmEgOrNe+oIrSsMhML199MlPfrL8xrIetd0x5vYpPsaCMtfrpFhzPIvUppLMtyOgSccohMJlTCgghkU4itfogJLW87beIA/rAOIxFqZJ7LqRVt7bz4hxWxiXtjDceOOmCLlr31tct75gnt4cvTDWUzwpy7333js5K+CcwDHHHJOUkYI12rAwzkjI2ydDlc/CtrhV+uhHP5rggLI/fih8uPGDBT6VkXssJB04mSLDjzRN/SmPaS4jP6M801kMA0xMmVlsZ+Rz3vhVNl+yy37x7DwEwkB0Xp30BUd51xElRtl8+ctfLuffP/vZzya91hNPPDF97nOfK/fQm8o44YQTkgVnCsp8ugVPC7sUsHMApkosGFtXMOd/0EEHJWctTEtdeuml6dOf/nR5RkFc89+MjLWN3XbbLf3oRz9Kpn8sWJsyMe+OPwvEDIsDfRZkTaVQeJ6mjeTJ2Jga4t5nn33KMghr/cOhPLxIl4JE0qJEt9lmm3KHlB1Z0plqqqkSZWk9waKy3UN4Vg69bSOFbLCqAkIZF0UxsEMJfzBheOUBE2ngAzYwq8Yf6W+8MBDqwhZW+DES1o+MkIworGso6y677JI+85nPJIZd/Xqf87O7zC6whRdeOHvFswMRCAPRgZXSDyytvfba5fy73q6eJiVLOVKelLTdMxaYLewyGLZOUnCMhR4/pceY6L1SpkcddVRpBOzW0eOm3KVnEdjirzhbbbVVcor3kEMOSRaU9da33377ZCeQ93gwijHqwJ/pLiMOyp+ytyDMsDjk5cwGZUtpi8/N0Hkvb6MXeell21UlDpIGxWhbKsPkdLcR0yabbFLuhDJNY/H3tNNOK3llPI444ohkhFFvsXrChAnJwryFYnKjzMcee2x5SM02V0YGPzCBDeUt3GgJfwwDA6h86gTv1lSK4tWpP7gyToysBX/bhZW3KF59L+9rrrmmnEpkGLmDOhOBMBCdWS89z5VeJeWQyTx8UbyqQCghbu8svmY3xV0URbnfnn81DeFr3UVRlHP64knLe789i6IoMdbjFdd774riVX9h+CH+8vMbCe+9Zz238Jln76skTlFMngc/fJQMTfpTFK+WUTz5ZiqKV+NNCjLwnzJed911y3MGjFFRFEl64qIqn9z4Gog8yh/SyHnkstYmpTw5DB7yeyMQU28LLLBAWm211bJ3PDsUgSmGxVcECgQCgY5FwDQNMuIygulYRicxZl3F+oOH3rTdAAAQAElEQVQRmmmzSV7xv4MRCAPRwZXTDayZ0tCD7QZee5VHPXRnHkw16dF3cjmNeFy14fzKaPl0HgWNNn7EGz4CYSCGj1WErIOAaQSnYuu8Cq82I+AMh2mkmmw7ymmnk07FWJiaaaaZEhpLGhF3eAiEgRgeThEqEAgEAoG+QyAMRN9VeRQ4EAgEAoHhIRAGYng4tSxUJBwIBAKBQKciEAaiU2sm+AoEAoFAYJwRCAMxzhUQ2QcCgUC3ItD7fIeB6P06jhIGAoFAIDAqBMJAjAq2iBQIBAKBQO8jEAai9+u4X0sY5Q4EAoExIhAGYowARvTWIeBuIZ+lzOSmUpTdnsK4XsKlfdzI5X8u2XPnDzfyQR43wfqdyZXUrux25Xf2840Gfm4bzX433XRTcqmgd9lPHOGkm/08XQVe9cMDXlwo6PI/YZCrx/HudyZlczNqdnu6zE/eeOBGeJOPr7FxI7e3utZbmbgz8fMuu8VxFTiMsh/sYCiv7OeJFzz5nQnPeM9uZVI2ZVTW7A8DPGa3J7/WSUuk3AoEwkC0AtVIsykIuDHUd6AzudYbZbenMJSibytwo9/85jflh4Bcy82N3Kjq+wN+Z3J7q9tYXcGd/dw8ys93obOf67t9fc677CeOcG6BzX6ertWWl98ID67H9s1rV2PzQ1dddVXCu9+ZlM314tnt6ROr8sYDN8KbfHyFjxsdffTR5feglYk7E2PgXXaL42ZXGGU/2MFQXtnPEy948jsTnvGe3cqkbMqorNkfBnjMbk9YNUUwIpG2ITBuBqJtJYyMuhaBFVdcMbmqOtPiiy+eUHZ7CvO+970v+e4DN3L19gc+8IF02GGHDcR37bdbUb3PRLm5+sFX1bKfa8R9M8JX7bLfnnvumdwd5F32E0fc9ddffyAP71xrLS+/ER7w4ubSI488ciCsK73xLkwmZXOFRHZ7uupc3njgRniTj2vLuZGPErkqXZm4M/HzLrvF8Z0MGGU/2MFQXtnPEy948jsTnvGe3cqkbMqorNkfBnjMbk9Yda0w9injYSD6tOK7odju7JlvvvlSJrd/ouz2FMaHaHwXgRvNMsssadppp03uiOJGM844Y3n1t9+ZKF5XV/s2RPabe+65yw/cuNco+3nvzinvqn7iUqLZzxMv8vIb4QEv+Jx33nknKws/YTIpm4v3stvTx43kjQduhDf5VMtM6btiW5mEycTPu+wWx4V+MKr6SU9e2c8TL3jyOxOeq37KxE8ZlTWHg4E0s9sTVt0gd8HjawiEgXgNi/gVCAQCw0IgAvULAmEg+qWmo5yBQCAQCIwQgTAQIwQsggcCgUAg0C8IhIHovZqOEgUCgUAg0BQEwkA0BcZIJBAIBAKB3kMgDETv1WmUKBAIBLoVgQ7jOwxEh1VIsBMIBAKBQKcgEAaiU2oi+AgEAoFAoMMQCAPRYRUS7IwMgbvvvrs8MT2yWKMNHfHqIXDxxRens88+O7nrqt778OteBMJAdG/dBeeTELj88svToosuOulX/B8vBN71rncl9zs99dRT48VC5NsiBMJAtAjYSLY9COi9hoFoD9aNcnFFB+Pw3HPPNQoS/l2KQC8ZiC6tgmB7tAi4aXTBBRdMLqQbbRoRb+wIuLNp4YUXThdddNHYE4sUOgqBMBAdVR3BzEgQOP7445NbQ0cSJ8K2BoFFFlkkufbb9ydak0OkOh4IhIEYD9QjzzEj8NBDDyW3qbqpdMyJRQJjRsDNrW5zvfnmm0eXVsTqSATCQHRktQRTQyHgwzUf+9jHhgoW79uIwDrrrJPOOeecNuYYWbUagTAQrUY40m86AhZDfTJzgQUWaHrakeDoEfBtCJ8kNbobfSoRs5MQCAPRSbXRsbx0FmOMw+yzz558+a2zOOtvboqiSCuvvHK68sor+xuIHip9GIgeqsx+KMorr7yS7rnnnuQrZlNNNVU/FLmrymg302233Zaef/75ruI7mK2PQBiI+riEbwcjsNBCC5WH44qi6GAu+5M13+lec801k0+d9icCnVfqsXAUBmIs6EXctiNQFEWyc2mmmWZqe96R4dAIvPnNb07WIpyNGDp0hOh0BMJAdHoNBX+BQCAQCIwTAmEgxgn4yDYQKBGIP4FAByMQBqKDKydYCwQCgUBgPBEIAzGe6EfegUAgEAh0MAJhIAatnHgZCAQCgUD/IhAGon/rvutKft5553Udz/3E8LXXXpseeeSRfipyz5c1DETPV3FvFND1DRdccEFvFKZHS/HYY4+ls846q2NKF4yMHYEwEGPHMFJoAwIu51tttdXakFNkMVoEVlhhhRRGfLTodWa8MBCdWS/BVQWBF198Md15550pLuergNKBP12/vuyyy6a48rsDK2eULIWBGCVwEW2MCIwgOuPg9PR00003glgRdDwQWG655dLFF188HllHni1AIAxEC0CNJJuLwL333ptczhefFm0urq1IbZZZZik/5PTwww+3IvlIs80IhIFoM+CR3cgQePbZZxNlM/fcc6eiiMv5RoZe+0NPO+20aeaZZ0533HFH+zOPHJuOQAMD0fR8IsFAYFQI/Pe//00PPvhgmmuuuUYVPyK1F4E3velNpYF44okn0ssvv9zezCO3piMQBqLpkEaCzUTAtwVMW+iZNjPdSKt1CLzrXe9Kd911V2IkWpdLpNwOBMJAtAPlyGPUCJx77rlpmWWWGXX8fow43mV2FfszzzyTHn300fFmJfIfIwJhIMYIYERvHQKPP/54eTLX50Vbl0uk3GwEfCxokUUWSVdffXWzk4702oxAGIg2Ax7ZDR8BXyc77LDDYnF6+JB1TEjnIdZff/2O4ScYGR0CYSBGh9voY0XMQCAQCAS6BIEwEF1SUcFmIBAIBALtRiAMRLsRj/wCgUCgWxHoO77DQPRdlUeBA4FAIBAYHgJhIIaHU4QKBAKBQKDvEAgD0XdV3rsFjpIFAoFAcxEIA9FcPCO1QCAQCAR6BoEwED1TlVGQQCAQCASai0D7DERz+Y7UAoFAIBAIBFqMQBiIFgMcyQcCgUAg0K0IhIHo1prrcr7PP//88hOi73jHO9Jqq62WfKby+uuvT1V3lxexl9gfUVlOOOGEsh7V5ZJLLlnGPfLII9O8886bsrv0jD8dj0AYiI6vot5kcOWVV05bbrll8kGgLbbYIs0///xp4YUXTgceeGDaaKONSndvlrz3S7XqqqumtdZaK/3nP/9JZ511Vllgdf2hD30oHXfccaU7/nQHAmEguqOeepLLrbfeOrn10+jhhRdeSM8991y66aab0tprr92T5e2XQrlkcauttkqzzTZbuuaaa8pi33LLLUmnYL755ivd8ac7EAgD0R31NCiX3fpymmmmSRTJmWeemW6//fZ0wQUXpCWWWCK95S1v6dYiBd//Q+D9739/WmWVVdK3vvWt8sr2v/zlL8nI4n+v49ElCISB6JKK6lU2V1xxxTTVVFOlSy65JJ100klpjTXW6NWi9lW53vjGN6Zdd9013XDDDek3v/lNmnrqqctPkfYVCD1Q2DAQPVCJ3VyEt7/97aVROOCAA9IKK6yQfNO4m8sTvL+GgHUlBt83PXz0abrppnvtZfz6HwKd/QgD0dn10/PcMQhGEYsuumj68Ic/3PPl7bcCmkI03RRrD91Z82EgurPeeorr973vfckIYs455+ypckVhUlpsscXSXnvtleaYY46AowsRCAPRhZXWayxbrH7Xu97VidNLvQZ128tjfUkH4A1veEPb844Mx45AGIixYxgpBAKBQCDQkwiEgejJao1CBQKBQCAwdgS62kCMvfiRQiAQCAQCgUAjBMJANEIm/AOBQCAQ6HMEwkD0uQBE8QOB8UEgcu0GBMJAdEMtBY+BQCAQCIwDAmEgxgH0yDIQCAQCgW5AIAxEN9RS+3mMHAOBQCAQSGEgQggCgUAgEAgE6iIQBqIuLOEZCAQCgUCXItBEtsNANBHMSCoQCAQCgV5CIAxEL9VmlCUQCAQCgSYi0FcG4he/+EWaccYZB+j0009Pd99994Dbuy996UvpoosuSi4Y40bbbrttuuOOO9ICCywwEHbzzTdP//3vfwfcwn3iE58o/bzjRuL4mtYGG2wwEPYjH/lI+WlNeQmTCS/77LPPQDj+1157bfnBFb+RWzEPP/zwhPzmh3yURVi/M0lLmtntKU+f9cQDN8Kb7wf7/Cc3cvU2P2XizuSzoL4Slt2ucT7vvPMSjLIf7GBYD2+Y53CewggrDjeSljSlzY3kKW+/M+ENj3jNfsrQxPYxZFL18ucH08wTrGGOtxlnfFX+8CycOsrhPMmKsvqNYACLevUNO2EywbZefdfDt1vlGWawy2WGKWxhnP1gL5x32U8cfmQm+3mSqXp4k0HvEdmE4ZDC0IMBpujBMjUs0oorrph+9atfDdCHPvSh8itXVb8vfvGLaaGFFko+cpL9+c0yyyzphz/84UDcL3/5y+VXsnIYz9133730844bieOm0p133nkgLqVAuUtXmEwzzzxzWn/99QfC8Z8wYUJafvnlB/x+/vOfp9VXX70kv4VBwgjrdyZpSTO7PeUpbzxwI7z5zOehhx46kM+3v/3t9Na3vjUpkzCZfClsvfXWGwh35JFHpg984ANJujkM7GBYD2+Y53CewggrDjeSljSlzY3kKW+/M+ENj3jNfsrQUABa8KJe/rCEaeYJ1jDHW/bDs7jqKPt5khVl9RvBABbqvLa+YSdMJtjWq+96+HarPMMMdrnMMIUtjLMf7NWBd9lPHHHJTPbzJFP18CaD3iOyCcMWiE/HJ9lXBmKeeeYpFavGht75zneWCt3vTHodM800U9IjyX4aKIFbeeWVB+JrjD52k8N4Lr300uWV1d5xI3E0Wt9a5kZ6M4RVXtyZfJZxwQUXHMiDvy+uaQB+I9/1nXfeeRPymx8SRli/M0lLmtntKU9544Eb4c21zBQON2JwppxyyqRM3Jlc22xUlN0f/ehH06yzzloaiewHOxjWwxvmOZynMMKKw43gLU1pcyN5ytvvTHjDI16znzKkNv6rlz8sYZp5gjXM8Zb98CyuOsp+nmRFWf1GMIBFvfqGnTCZYFuvvuvh263yDDPY5TLDFLYwzn6wVwfeZT9xxCUz2c+TTNXDmwx6j8gmDNsoVh2TVV8ZiGGgHkECgUAgEAgE/odAGIj/ARGPQCAQCAQCgckRCAMxOR7hCgQCgW5FIPhuOgJhIJoOaSQYCAQCgUBvIBAGojfqMUoRCAQCgUDTEQgD0XRII8H6CIRvIBAIdBsCYSC6rcaC30AgEAgE2oRAGIg2AR3ZBAKBQCDQbQhkA9FUvm+55ZZ0zjnnJMfYm5XwzTffnHbbbbfklKQ077///nTggQemNdZYg7Pj6OGHH06nnHJKyV+rjukfd9xx5aG6p59+uuPKPxaGyM+GG26Y1PlY0qkX96GHHko/+9nP6r0as1+WzdEm5OoWV6Y4iQ8D6Zx55plp6623UEUcpQAAEABJREFUTpdeeilnx9Ftt92W9tprr7JtPvHEE23ljw743ve+l3bZZZekXluReSfhP1b5Gg0+LTEQL7zwQnrqqafSK6+8MiKebrzxxvTpT386vfzyy6+L5xTkZZddltynkl/ee++9SZzsbsVTGdz18s9//nPEyU8//fTJ3TqNFPhLL72Ufvvb34443RwBb9LI7qGesLrqqquGCtb294888ki64oor0rPPPjuQNxlQvgGPJv2A1+OPP96k1CZPpiqbk795zUWJHnLIIemvf/3ra57/+5XLCwttiPcUU0yRrr766vTMM89wtozc4fTnP/95xOnjT5nuvPPOuu1WmUbbfobDjLr8xz/+kdTrcMKPJIy0yeEf/vCHluM/HL6GI1/DSWckYVpiIEbCQA5LORgRXHTRRelvf/tb9h54ulbAdQPZ4x3veEd5Z1J2t+o5ceLE9Mtf/jI1UvKN8nXJlysAGr1/8cUXyxHGWWed1SjIkP6f+9zn0rnnnpummWaaIcPqYe29995Dhmt3ADhogFXD9d73vjedcMIJ5eWI7ean1fndcMMN6eCDD046O8pezU+HwlUQVb9FF100DXnNQzXCKH4/+eST5aiKoR5pdFe8uNaiUbzRtp9G6VX96YD3v//9Va+m/lYfiy22WKJ7mppwFyXWMQbimmuuSS4QcxfNscceO1lvciR4XnfddWnXXXdN22yzTTrqqKMmU+yUPD/v9txzz4EpDKOd3//+92Wcrbbaqrw9lZ8Gs+OOOya3Zgp/8sknl6zcd9995fTWF77whaQ3KFz5YtKfu+66K7kdUh4nnnjiJJ/6/928iU+9tp122inpBQk5GP/eZ5Kn4e83v/nN0uuBBx4olepPf/rTclTlUrKvfvWr6V//+ld69NFH03e+8510xhlnlLwdeuih5a2zIpoGwyte9PT0+JTBBWV6uS4r8w5tscUW5XSH6UNxpW/6I7vlxcjD8Ec/+lGJvZ6wMnL/+9//TvgzheKGUgrS1Am8TPtI6/bbby971/vtt19SRvkg5TOdAHOGzmgIr6Yxf/e736Xjjz8+GeXJH55utvVe3E4isuReINOD6mU0vMFR/Wy55Zbl9E61QwVTo9ZcX+oXRvIxZUde1CPMYfr888+X2KkX+JJ3/uKIK6y05JHx1Jlj1MkNGSCz0q8l9Sc9Za62n8H4r6Yhvny02QsvvLCcSpIfXqrhqr9vvfXWUsbxraxkMr9v1P69v+eee9K+++6bYHrEEUcMTFkZITGAeHHhHxnVdmEgnpGLER6M5El3CetdL1BHGAhC+sc//rFUPl/5yleS3xTASAG+/PLLE+Xz8Y9/PH3qU58qb2R1bS/BQH4ToE033TR5brLJJmUWF198cfrxj39cxvnYxz6Wvvvd75ZTQ0YAlI0eHMFZaaWV0mOPPVamazSz8cYbp1//+tdp//33T8pgDtlV3y5M+/znP5/+/ve/p0b/XAD2wQ9+MOkBbb/99uXle4PxX5sOIWQgKHDvDIcpYfycffbZaf755y9HPm6TdTHb2muvnTw322yzchpv2mmnLY0b4YYH3l2TTGlNnDRqkg5MKBwGg+E+7bTTymvPl1xySVkmZaSIlUFD1HgWXnjhJB0KmxLTgBgIN5EyUnpllA9Fjme3ZK40CddlllmmNOw6CQzT0UcfPWDEKJSvf/3ryWWE6kNdum2TMcHvn/70p6RRI9dj86dUhCsZ7ZA/5GGGGWZIZNyUEcM2UtbUE+yKoigVJrlzhTvMpAVrOOdL5v7v//4v6fyQFyNO9c6AM8w/+MEPyssll1tuuWTUtu666yayON100yXv4GjeWx3C3bqaKRdyd8wxx5Ry5DJKhkfetVSv/QzFfzWNBx98sFzL1B51IF27zWAwNqaXq2Hzb+3Ub+1QJ4TccJOFRu1fWvIwWvvsZz9bjuzJD2zFNcKSFtliMBg9I0Dv4K79w1s70gbxR7a973bqCAOh9zzXXHOl2WefPa211lqJxTb1kitoOCBTZISYYVhhhRXK21hVFGuvMSANVOOi4CxuE3Zp6+USPgqbkLztbW9LhMZVwG7ItP4x55xzlgpKOip/qaWWKoeen/nMZ9Ill1xSKk5XDrsdEh8UnkX1lOTwepKHhkhpzz333GVDFa8R/7UpuBaaMs5leM973pOkQwERYMqbsXPvv3IwcngzJQBnSl8vVi/QUH2dddZJFDGlxbhQxm60JPSUPUWx4aSFYw0tT2lRDHpV4psSomjgiJfFF1+8HLW48RafjKY0GA/rTHqjcIcBLNA888xTXjHuNk6GRJmFu2jStCOj8slPfrKcdmIcNFRTf7PNNlv57Q7hjZpcn60sDJb0pdEJRD6NNnfYYYe0yCKLJLePkhflGgl/OhE6T5Q5nNU1LE499dRyU4jRoeurV1xxxcQgwEed6fEKB0P1q26vvPLKVBRFmmGS0VKnwk6YMCGRDQvAq622WlI/jIBRs5EJQ2NEQBbkQcakWa8M5K62/QzFfzUdfMKJzGpnm266aTm616mRTjVs/s2YrTip7MqHb7LjnXZbr/2TrwsuuCCRPzfr6vjRH0b/OoPiwoDMogMOOCBp2+TdLINRF50hT/JvZEZ34VHcbqdxNxAaCOtsbtYUjt4OBUaxj2RRxvQCYmhypbgOW0+NYCDrAvkdBZrnvY049BzsIHH/vp0ZOVztk2CKRxmh66+/PhEoipBg6A3nOBpd/j3UE++oEf9Dxc/vKcr829OCp2ctUe56RsqAjET0gvQwc1i9+fzbk4KfOGl0oW70BPWeVlllFa+SaQbGRVpI3cE1NzLpUlBl4El/7NKhtCb9HPQ/+VB3sKRwBIYRunjSyI8bMUBFUfhZkjoUt3R0wB+jHOtA559/frkxQaeDm5EbCXumWmCJxPPU4cl4UoiUnXeIrJJ1RtzIkrx+//vfL0fIlKkwtcQYMB6Mv7rULszF67hRiowvxS9eURRlh87v4dBQ/NdLQ9vKdU83GO2Q3XphyaaOjtGrvHIYMlSv/ZMR2FnLMyW1xx57lLMLOoA5z5yGJ7x1YMg1o0/m8eQd0kESz5QVd7fTuBsIPRVDWb0hIwY9Yt9TUAEU7kgBJhw5jsosiiK9+c1vLr1qK01viFLWeC0calgbbbRR0uDKCA3+WEg0ZWK+ERkpED7GCDWINizvwfgfVgIjCFQURWIQlSGTKZ9GSejhr7nmmokhN82gx1QN69sFOR1Pw3u4VMOM9reppKzQKAzEKIw2vXbGY0wZM/iQceQbBEZW8DfnPxJ+yBgSpyhelW94FEWRKC1TQd4hCpCMy8PUFkXpq2o6T7ldCFdLOgeUrHpE1ihMsehxG5HIpzbOcN14R8IXxeT88xuMjIJNXdULgy+jcEZQ+YxyquHqtX8dHmF0jqyDKSvSpo0cvKuSTg7cqngz9DmM9/QOI5H9uvk5xXgzT9EYppo2sMiDDJtZcAuVGtdweKS8TKOYOyco4ohLiWiIhJvy1RvyDplnFIeB0CAMlfVMvWtEhpPCa2jC6AWbH9Wzyr20nL/3w6Wh+B9uOsMNxyAzwubtcxyjI73D7K73NKdt+Mx4wyKHMaTXsExpZT+LnPn3aJ962ng156tnKx0KFlVHa/w7lYyuTNmR7SrtvffeyUjO9NBweTd1J45erzgUNhlkcMi6aRKbEbKRYBjIqoVdbc1iqqlUYcWvR+RYPKP5/N40jM4bxUfW8cCd3w/3ORT/Q6WjbeksmAqqDWvUaCRgGlMnkxLPYRq1f1Nq5Ius3nXXXWVw5TPygmvpUfnDsJniy3ibbtJuMt4wsV5nurcSrWt/jpuB0AMx5LU4ZB6eO6PIClPYlJUhrvUARCiRPdvWAUyfqDANUFzzgXoJlJ4pK4tHekt2jei9WUy1UGUhW0M1t6mh6ClQenoTFJEel8VXi+UaBGUkX4bBdJK5WumaT0ZGQIbcFgflbypGGnqN+KI0CbXfVdIQ5YssyA3GfzWe3/ae5/Jr/DDBo6kBv/Vq4Id3buWEsykO4cw7b7bZZuWOD3O1ymFBW/mEx49FaqMs+WVSTvPC7373u8u56+xvftYUBAUAX8aWAZG/NSZ44lN9UfQaOiVnVIAXO6jgaNoKXvK3tmMdwYK+Yb1dJpQdxcXfnLROgPSlbS++xk1WyId8Mn/j9TRChqspN2XNfJB3WOJXz9X8PoWkzMqujoQnx34ro7ArTVrQp+D16OFHxihzmxAoxG984xvJ1IoNGNbg7PpRJ6boyIC5dWnpZYtnatF0jV65tMitXjqZMOJYbdI6hDajXfiynQ4VuTEXz+AoH4VJvqWby5efte1nKP5zvOpT+3BeiAI3PaYdMwDwoMjhhW/yR0Erv/JpH+QMn+IgZSGfuf2LYySsbGYGdICsy5EveoEuMgrTISKfJ510UnkWywYVeJuSYphMFdIfZhasnZD9ahm69fe4GQgKTEOnbAgfYc0g6pGrdD0BvVyVg1h6RFjsZhCe4mf9xffbCIGwWBBk5X3sXTjDPouyhJ7SEtZinkq2MKwnQCHqmVCWegAERm/AiAZPlKJpKEJqxEN5Ul4UlTykQYCKoii3c5quIWyUm8YpTJW222678nvThJmSxFMj/qvx/KZIPMWxzRQmsDFX7LeFREKPP25rE+aUYcO4aOimgJRFL0pYxlpj0COCHUNIocgnExw1MoukevfZn7Gzy8lOJvhqQPKmwGFnyG+EQcEzUjYJUE7qzaKyRXfh4C9/hkpvkLK3QcCuGuVjhKVhgXfmmWdOlKeRoXLjn5KiOMUnA5m/8XqqJzhRboxg5oP8MxymNGGt168syox3c+mUrt1cFBhslI38wYISMsK2+KoTRdakbTT+k5/8pNzwwQjpdKgbClU4nRz42O0jH3PmetfqlIHCo7SdToafjho5UK86GBQqJWq3E1k3B6/+tFX1hIcq1Ws/g/FfjZt/45/cUsZG+HvttVcihwwAA5Xxw6dNKORDJ0c7ZjiVQRnrtX95kDk4KaO2YRqVfDIO8GYMGQsyp9MlbC4r/aUeM394tVCNP2l3O42bgVCZgGV5Aa83lcHUIPhnooxRdhNe84usNb9q/GWXXTYxCqaPKKlqRak8PSy9L/E1XHlSkJSnHSAah90f5jLFFYYBMBqxGEVohLGgReFpGBqNdFDOX/jVJvW+NGJrGtUwwiH8GO3ozciLX45fj3/vM1kAzuWHB4IF8hv5jfzWQ7TDh/LQo5SOPGEkr6997WuJkWDIGC7xkC2RwmZSfso4K6Ts76mhwRG+DIi5WoZIOpkYy/zbUxzG4aCDDkp6vQwZ7LxD3kubYjAlA3PYqwO81KZX6xZ3PMnISjkQ3jIvVfn3TpntbvI7Uz3sxNdWyDEsKCMKkj+COezVgbogY/zJn84KmfFeGyPvRiPeU3TiUIzc5MVIQR7ykid/ZLrM1lpbXRkLMuR8SlaawmSqbT/8pSVNadfy730tKQP5FF7vP69r6YBkrOBHdklB7IEAABAASURBVMiQclDypj2r8i4d+Xpfbf/ygyFe4KPDqG3wNwLSfo1e5W+KTt15h7xnaBk9vMAMdt71Ao2bgegF8KIMgUAg0FoETLGZljS6aW1OkXo9BFpiIFjVqaeeutxjXS/T8AsExgsBow7TBa3I33REK9Lt1zRNEVmfMcdvlG0dp1+xUO7xkK+WGAjDf9vGDC8VLCgQ6BQEzInXTps1izdTNs1KK9JJCZ7WoJANI+qun3GBR7vL3xID0e5CRH6BQCDQXAQitUAAAmEgoBAUCAQCgUAg8DoExs1A2Httz/LrOBqBh218FrBGEGXYQe1Bt0VzsHlPe6y9d1hp2AlXAtprbZunclS8e+qnOobTaDEaKxjytcDZCoyVSx2OlcdqfOnZalz1a/RbOFthtaVGYcbiDzPbzJ0pGUs63RaXzNIrZKddvKtL1K78hpvPuBkIZw4o1+EyWhvOyUUHexyicY7AHucq2VduP3RtvOG684E3l3A1imNbm612Duw0ClPrXz285YCfrY32UNeGG9Q9Ti8pRDxbNKzHgsNeuQ6cW6GYxVEX9vhrePXitdJPo8OL/Judj/qHR7PSJRtOLDvv4E6ljGV+KofDWjk/h8Rso9WWsl8zn85E2MJqa2cz021nWoycnVBkVqevNm/nJTK+ns42OQsBf/JcG75VbmeDnGlpVfqjTXfcDMRoGRZPz95tivZ2O5zmYJZFLDsdNCLGw/UFFiMdOBJnpGTHgNOnFFyjuE5o25M/3MV4p30pgJye8xcOfjl/kP069anRUFzuqIFxLZ8WEu0vd08TcqJbb9h+cvv/+TkhXRsv3K8iYCTpTIzzHvbkM66ujXGgzcFBhwHt6HGWgVssl9aNpHMizkjIfn8HSRnZkcTrpLAMuHNR9AV5rOXNfVNkEzlxzYg4T+HsA4Xt4GJtnH5yd6WBcPLaiUa9b9cCOPjlNKdDXg4AOUzjYIvegAM2wo60UgmJBjhYPA3Z4TONaLBw3uHBAbSqwbErw0laeQnTycRYuudHI9Mrq+XViVrKjJFADufZTloURXktOiwdZqqNF+5XEXBY0QEyMkWOHbLMOwH9diDNKWGjBgdMTfuQH6ebX02h+X+l7xBj81NuX4oOWpLDarvLubuSQ/nIK2JIlNl7hwEdpnN62xUa/JpEXZVM1xkI862u1nDthd5pRpuhyL/tddfYnPjVM/MRFScknfQ0HeXUqNPXemnu/nFyWs9NT9fIgxKUlnQoQ1cKUI56/EYqpkoMTRkhpzWFRUYyen3yFdYV4u4H0vumHA1ZDdc1eFceuEaBcfPxIvHlZTrG9RkE1SltPXPvGpEej2k2J0d9t8FpT0JPubiupDae8IxVI6oXRxrwhXc9Y6iMcDNicyuuEZzRXVG8ev12URTlHfp6Y+5kkl7QawiY/oCNOnvNN5XfCMlu+JN5J9jJi+mo/C4/ybMbAMgq+WewyaT3ZNpVKEa97iCj/IxKvGNsjF7IjXhOYJNZ77QBbc51E24SINvqMM/PD9Z+xG9EysDo+c6Da3O0PdfbuFKkNo524WqSRjLrnTC18bh1bJwu97tK2jCD66aDbAQYkmoYOgEmcMvlrb7vh99TdFshLZoRUMfm6/GuIah80xmmdAi121w1Hg1BY3SZHsVO4Hx5yvF8F47p4Rt9GG7mtA2vCQ5l7ki9RmdOk9BpOLkhCW8u2DymO6ZMA2icjISFREfxNUxC6ZJCd+CYmqoaAFM39jq7H0lDMU1jCCztwagoivKzogyFe2fEUTZ31dTGM6qiRBqR6wZq4wzlZjgYB4bP6M73BxhA9ZDjKrv7ptwRlf3i+SoC5BRWRg6v+rz2l2Ji1ClA4civ0Rg8Xwv16i/yo/NkGpNSM71K1rwl06aoyLH3Ojju/SKjOkCe5Nq9XdIw3YInca0VupdMJ8A1Fy4BZKDQUO1H/HrkOgprHDpw8nYlhmldPfna8GTZvVCNZNY7YWrjDebWdt2xZlra3VSu04FDbRxYG2low7Xv+sHddQaC4idQjaZlXFznIjFztRSSkYJegB69E96UmJtGkd52URTJDZOMgB67HpLGlRU/5SeOHo7escZqbtL8rOFrFhI9b58b1DPzDmlI5u0teOVw+amh4Su7PV0C5i4cPUC9F+sTRgbeNSI9S70+Dc6FbHh1kyQDqpdWG8/IhBFrRAxZbZyh3IySiw/dp2Sk5qAkbDXCalyX7RnNVf067Xe7+aH4yTT5qzc600ExKnWZHpk24nSpXD35d1upDoj2YbTqSXGSZTJtQZvMagtkU4fHO8bAhg8XWZrq0iPX2ZA3PFxFL6wr+I0uGBeL5QxOUQzefsSvR9qHzhvZcaGe6WIdOUawNryRv55+I5n1TpjaeIO5tRcXG8LBZgO3M7vrSweqGg9W8EBV/3753XUGQm9Gz9sURr1K0tNhIMzT6g0Rvmo4DTG78+6h3DClaw7YIni9OUvK1TDfFricRn4a2aCcFn+jBAoAz9xDkRs/q/y5NMx02FDx8vtq3vzqCbVenzI2ovyFOPFHQxSQURaMjNqqaZgvr22A1ff9+Jt8GNnCxnROLQZGqhQZ5W30hch4bThuskkGTd2Q1TwiIctkOrvJee5IyJ/bJXPiuR7cqMMom790q2TkQqkbqY+0/VTTyb9r82DQ8rv8NGqy1tdIZr0TJocfybMoivLmW2VnLLXBanxTVAwlY1v175ffXWcgKEFDXz35epWkZ66nivRQ9LDrheNHOCnvqtIqiiJpSN4JUyV5EqJ6vTejEw2coJoWEK8oiiT/euFTnX+UgZ6bRuu1chrW+90s0sAN7RuRNZax5FUURaLs7MyCRzUt5YFH1a/ffxdFUcqIOs9ykyr/YKi3baqDTFP8/CpBBn6aWrTQqnNkJJs7UcLD3XqBOhCBLJuCKoqi/L4BBSgPoz+9cSNiRkDYKvGTRm4jI2k/1XRG8pvhM/3TSGa9E2YkadaGdXMuY1DtoAmjrEVR9O29ct1lICbVmOkTPaK8wDbJq/zPymtg3pUeNX/4q+xqD8ECmWDmYvV2GQoLrj6WYnrKOw1Cr0Z8DUpDy2cj9Pyk6Z2eszMR5ngJMn6sAZj+yeEZN7164ZEpGDzrbcvL3L25YvxYEzH0F47yYDisbXALWyU8Ivzzlya++HE3iygROOmNSl+6nsprdw3ebLs0ZWIkUmsYTU3k66XFDUpJR8TCM7mDbRUTeKpLslT1z7/VBxkSTj3YgGFq0vQJmVX/ZJR8mX60EG2qiWxZGGY4GHPvTC3xMyWa5Yy8ykt9m4NXt9qAaRfGaqj2Qw6sZ+BFOlUi03iXrt/eKY/yZje/sZL0pKtjB6Ocniky02rKBnfTxtYhag0NPWNHk/WRHLefnl1nIAg0JUOwVBRhIrR6TQTYfK1eFIHwHlFg5sS9N/1kMY6/MxS2wVLE5nXNQUrbXK33Go7FbItZtm1aeLWAbO1AT9sUlh07em7ys6uJcbFTyZBVz8air/DSk66dRhqi3pwFaQ3YXK4Pn/jmhbUR6yaG+Pj23QcNXOOWJqGWVibvpOlQ4JFHHpkQvjR06zHu7M9hx/LUo1Qu6fqIkMVEeWt0DCHeLFTD2bqNOeusYOSrvkxJWOfhDnoNAcpWz5VC50uWyDBZJrNkm4yTde8z+baBelcf3pM9MkMOPY2gbRrQcbCYTLbUE9miIH17xCjDLj7tygYN79Q1nhgQU5wUrHajrZBTZ2FMMw3Vfhga34kwx595zk9yaZ0Ef8qnvDZ2aE/cMMhhx/LUNrU3C/jKkNNycNKit3Ud+Smz3/l9floTsTZi5Jb9+unZdQZC74jS1Dth+fXoCapK1oMijGuttVY5TZQrUq/K18ZUtoVfPSDv9N4IMKVK+Wk8O+ywQzJN5T1jYc6XwuZvO5zFau+MZCya6TnbqWTILV3pW2w2Z2w+V6MUHsmD0aA8GR5h7chigOSp0dmRQZgtFmuwei4UrkavDBqQtDIpg56cnRYUisU2c7K2TTocZMtsDjuWpxGVj8QwkkY58pG3qTUL1Bq8L9QprxGTeqrmp9eqpzzUons1Tr/8tlZlkdauNWUmS2SYLJNpsk3Gybr3mXQoKFUdAorcWSDrBzo7FpT13nVopJ/bgBO7ZIvc6xkXRZHUiw0W4lKo1iO8k4/1D+2DMaJgGQfGwzv1Lx3vyXZt+3HGhyybOk0piTJAtvTiRc+d/CivsDDghsFA4DH80CljQJ3TYRByUowp3LRpYciztpbf56eRu+m6amcnv+uHZ9cZCL0aSkYPwxbRoigS615dwDKHSnHlCqRgDR2FIdx6a/kd4dV4vDNNpEeV32mQ5tLFRZR4fqcBmbMVr5qfaRVhvRNXGjmOfPmb79Rjw4v4dolobMLl+EYd+OZXFEVptPTelZ1fJnhYV5AOMqVVddvNlMOO5Qkn5ZIHkoe8paks+Z1eq7D8M+kFM1hGU1V88/t+f1I+FCwDb9qF7JIpOGci40VRTAYVGam+hy0/cmw+XRo6LdIXkQIkc8KQRX5IPZJtsln7Tlx1nd/VGn513aj9kAsjTLur5FMlcpl5xyequmFQDT/a385W5HQ9czoMkM+Q5jUX7vzO0xoNA80I6wzy60fqOgOhkvRm9Vz0eAx5+fUymYM2Lea8BgPSTWU1LeK6A7tmDNW7ifd28koJ+2b0r371q1Q7SmwnH83My4YNHR+99Wam2+q0TKmZomM0jJpbnV8npz9uBoLQ6GGMFhw9HXOnKnO0aXRLPD1D6yFGB63iuVXpWiSk/JwvaVavcCS86gGbvtFjHUm84YQ1raOHOpywwwmjjtddd93EqA4nfKeHMbWlTJ3OZy1/ZNZIqXaLfG24ZrphZZTWzDSbkda4GQiN1jB4LIUwZDaEHksaEbe1CFDQ6siztTnVT90UnykXU4L1Q4zeV6O2bjT6FF4fU3qmJl//JnzahYBRj2mzdsqsjkYndgDHzUC0q7Ijn0AgEAgEehuB1pUuDETrsI2UA4FAIBDoagSaZiBsWbOzqNvQMN9rCxzyu1n82/fvHIItsvZYDzdd858W3u2gcD5DPNcn4M9WRO5OIwe17Ge3ZbB6ELET+FSnFslh2mx+bNHstPIOt4zaq7MHww0/3HDO99hGa/vtcOMIp704xOfWY267uZz5cf/ZSNqPuO0gG0dsm4chLNuRZzUPmNS7460aphm/m2YgNEKKYqRMWWS2V9te7Cq5ltje63qnMEeax2DhKRDCjPweLOxI3imXMw5uqaTghxuXgXB4zhkLSlc8wuga8GZfuyHtWqLwUK3/YG64uRiQASO4jcK2Q6Br88abA3oOi9W+G6vbtuPByvu/9Os+nLi3gFuVeb+dn6F46kZqoqf2qtPRxCTLpGxppjQdRCs9hvmHQbAV2qFRURzCdAjQuYyRtB9xR0ruJ0MjiedQoy2+PhgGy0ZxWyXzMHFGplG+zfJvmoEYLUNAdsDGIat77rknuXLbVdd77bXq2teqAAAQAElEQVRXcvjKlQ16F6NNf6h4dgi5DRL5PVT44b630Ghh1H7q4cYRzp50+7Xdv8NY8JOW/doWXLlbRYyaw3gM0kjysOMDj5nf2rj8NRSHjmrf9avbtQ6Mvqum3dBqG7ODbQ6K+cznYEqnGZg5NGabeDPSqqbhPIw2XfUbzm/nIGyDdm5CeOc+fNWNTHK3isg6HBzkHEkezpFok4N1ihlLo+qRpNtpYcfdQGRACId9x9x2EbjXyNF3lr06hCNA7q1xjN+QVAMTJ5NenZ4RqvaEVaQrIZxkdh9+NjruYjEs1uORNkXm5CVyEE9Pwegiuyk7d9gTKn5GCXqpOX9TGU6Eyl/PNfvXe3pvGsnJZNcOjLQxuNtIfDhQvnjN+SgvQ4tHvOIZ7wyWPd6Uk3eZf6MWRtLUlvAUFjz07Az1hTWiqfIIQ70++evtSTvnn5/y1NNxrbKrvl0JkfGUJqzwpj65pZnj9vrT9l9yn8vpEJvRNLzIA/zzO3cCwYqsMB65HoQh597BT71V5ZHbyNP7PNrROyfvpsjEF0Zc5GYAeXpW3eRDO5Q/3ig/4ZCpZXXrnTQpXf71yOV+0pE22dH+6oVr5Ec+cnzyWBu/XvtXRjpDW8FjlX+HE91o4IYAbV++8KErhHWlTnX0qdzieyd/4esR3eGsFv2krGSe7PstTXqNjtApMPqul0Yn+HWMgbClrCgmPylKKIuiSHrV6X//CLZ7gFS4O1bck08ovKZkVDbAHThyyIVAUZbchIBSNUdq6ocguJNGo3SfkUanJ8EwufuI4FNwGpAL9PCjocqfktWIjHhUuPy9M0VAgPCkUfKvRxMnTkxGThQ0heCQlHj1wtbzoyR85cthJPwZcZm2EFZ5Xb5GiAkqfo0MCLfwwsoT/65lYCAZl6IoksbkoBbDILyrP/Rq5aHX6a4lecDVVSIauWtPYCBf76oEv6IoEuMhTQrChYWuOXAVA2NkuOy6Bvngoxq/13/n0/K5nDB0XqQoXmsLZB3uZA5GcKeIYcvPPD255ac+KTfpaQ/kloyTAfWnThlkeLu+RRoMjBG862TIuLjqyd1LpnjJgytnyCq5diJep4AhYgy0LVOilB6ZJ3PSqEemZChFitMUsmnJeuHq+ZE5cZSPzPk2hfvT+AuvvPXav46YsLAjx3r1rqZRdmWgX8igdOgAitz6oTzcl0Zf0AXy8FEw7Qym6oRfPYKLkRS5hzdcdeJc6wF77+kYeKmTeml0gl/HGIgqGMCkwPVm3Ye03HLLDbwm6NyUuA/U6LELRzm7J0YDcWeMU8cUrl6T3q2nobtG4DsLKlnPwB55w9msmNyo6u4V0zz2QqtkYdxPw49CM3XE+BBO7wgKnt2p5BoNfPjtfpkBxmt+aJSE1eVoyJkOI5uaYHWdBMrcrOG8+5pcJOjiNY1PY1BeSt8FbYyQjxBpVAyifAm7i/Xwr9xwwrdwzqY4gOguHz0qDUdZGTCHGzVAWKsf7zQ2ebgPKo8Aq0xrfHrJesfm3PWq5MPwuF+IocIvzBku5wCq8fvlN8Og/sl1lnnYqZ/zzjsvmXLUGSFb9swbCYtDwZID7yhBSo1cqSMdH21BpwUx5nrfDg2SediatnRflzp3St+ULn9hyLC6uuSSSxKFpm0xTmTNh6HIvPUSIxRfZsMDI6R9SKMe4cG9R64WcbreNHK9cPX8GCmKmbxpMwgfRgbKCxs8KnO1/dMRlL9rM+DgkK3OEWPgMJx2rq26y4ph1NlRHuWnL3RmGEbtgXKXv3LKvx6f/FzjQb5Nv+rErrrqqokRxiNDKn/rrDpu6lucTqSWGwg9Uj3GTJTTYEAA3XykylERGk0WZvFYc8Lszh8VTfGz0EYHBIFiMxpxoR8D4HSiXpbdEQ42mStX6fgxmphqqqkSIyBt5HS306yGhNKlVPHMOGiwBFrPyqEWgsVgUNiUnKkY+eoVStN7adYjF/YZDRF4il1cAlsvbK2fHiXF6o4YZTUlpyHDmjJRXjzBDc8MhfS5Xb5mZEHgfdiHQaGEavPgpoQYAgfdTIf4XRRFUlZTCi7lo1T0eCkwT/GGoqIokjrWG4MBTCkLuA0Vtxve6zUynmQMmQZRN41418uHL0VNqehhk1XhGQG9XUpPGIZW713PnryIqx2QAfjxZ/z19ilvC9/aigvw8KDeySa5L4pXRyncOkb4dMGjcORfR4psUGZGDTpD6o1x19bkT+GTAUaqKF69M0xnB+/1SH0Lq2dOnly4WS9cPT+dIus1yknWVlpppcRYMnrKi6d67V+H0lQSfaATQq6NHIwgavPRWTIicpAXbjo+eFSP4mn3Cy64YJK/ctTGH8ytA6Uz56ogHS2dTtgNFme837XcQLDsK620UspEUQ9WaKMCQ0XCaDqEwFfDu1SMULL0SPqEzaKRcJS5Z6YcX2UwCOIgijnfzJrD5qdGRbnrnQnL4hNE7xmQ7O8dA2V4raI1LD1w4YYifNsCa5pI7yX33IaKV31P4LM7N3iCy4+BwI/fSFiNwghCT4ZhY4QbfZ1MHMRgK2cmU1vqhuIYblmlU48YLDfPanyUUJXfeuG7xY/RpaSzzOst68E24p8SMv1BkTH8OiZVLCgUvWeyluvBCFjvVDhGJKetjtU1NwVGaeY4nkZw3tWSHq8bVn2ylGGRdrV+GQgyKw3EgBjtmTZkYFBtmrVuMmNaRVoUrY5WbZih3Lk953CwMQrK7nrtHwYUMt2jI0IX5PD1nm4kruoK03dGz9KGS704w/VjJKyvknl6bLjxxitcyw2EqQs9xEx6rfUKS3hYdD1eQ1i9akNHQzkKOsehuM0R5kZBQC0WUTaUo4aUw5rzoxAZFT0MaxP5nTjiZnf1SfANPfW08c2Q6KkLI39rH+ZlufFh+oaQ4t2Ih/9QJA1DWb0iioTgDBUnv2eMNAzzpNkv48e4ece46q15T2noGeFV75TwmzIyAvG+ERk1wcB6SQ5DqOVFIQy3rDlu9Ulh6pHppRr96JWaHqmG6dbfevp6qmQHMcSNFIsRqnJS5q71JkcMCkOhPZA7o4PqXLXRifd68Hq5RhiUl3QoHsbWFBEZsBDKH3GbfvK7Huk4WD8wjStdMil/v+WflbPpJgYN72RR+0T10qz6kSMdItM3jKJOTfX9UL/Jto0XDGUOy0CaJRis/ZN9ZK3GtA7ZzfFrnzqCRuAwhL/0tSO4GBkZPVfzr40/lNvoT7sy1WRK0OhnqDjj+b7lBkJlUESZXG1dr8CstKGc3pNGoletQq36m2cnkBSdOUQNiR9B1lPTIH1fQQ9ML8G8uG8ymDs0v2fumyCbYySgjA8hwJs0VTjyO/NGaRFgwrHIIotk72R6y3SWbYrmIzVmvXUN3DCdgaJUNWJGSZoahjADiUz6QVlrzHp7yi6MsiuvuV1klDMpaKII9N4odtMAGr9ejrlfDVfaBM/0FpyVGSZ6i7CCCQFXXvlKg0Ix7cRf/tYsvJcXRU2Z6N0rh+9dGNmZ8hPelIZrx01nmfITBk4Uh96zMqWUsD5AsNQzVccanwVSvUjTVNYf+JtGyUpoIGIX/tDzpgTUBSIbFG1tUZSVwlF/iAJ0hkC9k291S0mbFiRz6pzM220GL4bDdKkNFgy+jQmeEyZMSKao9JbNf1tD0h7E09lRx1V5ynxpm9qIKUw86/Boiy4lVMc6TerbQrH48scT44BvZdAJU/86ZuQ7p+0pX2HIuffatHJY4+Cn3Dof0hZeGO1H2+TW1mDmrIR04IMv02eDtX/54lEcZSOH0rSTTxnxYJSho6fcpvF0ZOkKIw+dKlPT2rz8jPx1EMkxA6JNcOOxSqbC5K2OtW8zHQy09QhpkX/1I51qvE763XIDMVRhKRWCa3HOCIAAUhgqgjI2nWN3BuVHICgtltcIgFAC2CIoYbVgRWA1FEJAkPlTqBSlG0VVEgHUg9H49FwpWuR35lePRCM1xYKv7K+BSYvAUZrSpCwpAAKlHIyYYSwB0LhMf1XTkBY+CaPGT0EbwhIee6ulTyHoGVL2DA7DQ6jNsRI25TYd4EkZUPiww4dekJGJcsNKT8/uCUraU4OAsV4t3jUcC4tw9MU3BkUchkAPFP94MrKibJRFL1B54UkRMWhGQtKEuTJWibGiAGCj92thX90Ko4HAwFM98+t1UvY8n24kBkNTNzoj5JBytdCqfsmGNsLPkzK0hkW52Xhh4ZiyM1qhRPWoyQF5kIYpW0pYx4jSqsqTdKpYG7FbRCa72R9PFlN1ssi8ESq5kQdlSmFro777YOqJ0Sd78sppeJJTHTptSodGx0Mb1NbxZD2FbGr35FcvWy9em7JArC1R1kbfZNxaAZ1gypPMNWr/ZiS0K1No9ALedWS0LWWx5qh8ZJ6b/GvnFvl1lix8k2s4wJn8SlM7VH5pM6TKWCX5aOPqzEhBG8K/jh68GCt1rpw6rNW4nfJ73A2EitXrIfyZ9IgoaCCx5NnfqEJ4AqOnYj6c0AiHCLA5Tr0Bc7Tc/JE5Vr1zxsHiKAHmb7SR0/ebXyaNkxBltyfliA+jA0KmJ8A/k7IQAAZHep4WHvGdw3jq4VsHkAajx5jpUWlk0sg86dkzZtlNkSqLNOQtPkGlrCly/khj1MOHBSNB8PkTWMoCKZvGAG8Nznv4MU6UEDejYVpJmfDFL1POn1KwI4oi0ghrFYPwRnG2NkqfsVAexse7avmUl1+vE0Or5wkHpD7IPKWvF0+++esEkR0yQt7VtZEqPxhRsIwCf/VGYfFH5F/9qjtyaITAfzC8yQfehKuSdsaQ4ZkcZHnCLyNDBsiiRVgLwtot3qpp+K1Tg1ejUYZPHIpUntJWZsrUjigdCm49cEZHfIoZVvyt/VUNmfKSLzJfbf9km4xLTwfJbiZ5KCsjZ+TKcOQ8dIzyzkgL6dqqvFHO34jZ9Kh4jF7GQ5hM+GHY5K1DJf/cfq05cisHXow4c7yOeP6PiXE3EP/jIx6BQCAQCAQCHYZAGIgOq5BgJxAIBAKBTkGgaQbC3KWFnE4pWPARCEDAuos5ZgvA3M0kUwvWEZqZ5vDSilD9joCpRNN0rcahaQai1YxG+oFAIBAIBALtRSAMRHvxjtwCgUAgEOgaBMJANL+qIsVAIBAIBHoCgSENhH3UoympAyT2xjsxW0tOMDtAUpuuvFCtv7MS9g07O1DvfW340bgdyLHnejRxq3GU22EmWxGVP7/L6dtr7YCdwz0OB+X3jZ62xdnyZ5tcNb1G4Vvh7/CSMxlOsbYi/do01YMDfeTG+Q6YCmMbpG2H9Q4leV+P7Ku399wZk3rvx+Jnu7SzG6NJA1/2/ytjldSxsrvPqZquba9ONNfLT3xnEZzyr/e+ms5of2f5HW38HE/5tA1tJNerJxLGXVG2l9ueCyN+g5G6tT3VttbBwrXqHVnVjp3roNdalU81XbKhXah3GOHBezcTODGurriR9zAarfwPaSBkMhpy3sApT/voHWSxj9ulcfZgWEqjfQAAEABJREFUU3aO9ds7XU3bqVNU9fPbXmuHUZw94G4F2ZNPeJuRtn3X9v3bYy09Dd5eZwfSnKPgZ/+z51Dk7icLre0Svlp+GDSH2tSBcxO175vtpijUs/305MWBQ3v4dRLsebfnnjL0calm593O9FyTQlE6oOgAlrIih8ecIXCoShvKPDnj4jCd6x6yX36SD2dPKI3s18xnVX7Hmq42oW1oIzktZwkQt1Po8huuvDvL4NCquE2hESaSz5jQW+pohNFHHFw7cK7CWQ7y45AdoyohOlZHwmE+7ZbfWKllBsJBNKd/HYpysMupRA3d4RYH3Zwc1BDcCpoLYVUeZXd+Eip3OtU7rZjDjOXp4A6l4wqKsaQjLkXqdDTjSNhZe8qAgfBbWeBR7xCR+LXk8JQrMGr92+V2Yt2JT7t1lK3V+epVu8zNYSVXpTh5bdSQD9Dx11N26FHvqNX8tCp911ZoC9qJy9u0DeSEtR6xUaY7nHJDF057Uv5ansiSQ1lF8ertrLXvx+Ims1X5HUta4moT2oY2Qp50mpwAN1L23igJ+T0ccrqfgRxO2FaEcR2QjguZbEX6tWm6HkeHzayCNqDenQLPo2qHLN1BZ8Yljyxq0xiJu2UGIjPh2H/+7anHpBdICbg6wgliPQaWz30xTh8LhyhsJy/dOMpaGlLxryXxWU2nePU8pCkPCiaHFcYw1H1NroRwHQcFIw+8UODiu4Mpx/EEvBOTes/IKU3PTKy3vLmNjJTJ8Jng4EXPyNUCDJC8DQOli+TtVKrTmfw1Rv6ZVyew8UMo+CM4Sc+wUVwC4UQmtx6mqz/0vvWq8IYv5DoG5fcbKZOyuY6BW4+13rSfE9p6uBq2/Bl0+DpV6zoE+bmbRlm8HyvByx086o9hdLJc58DFhvjTSeBnygv/Y81vPOMbHebTzZkPPWvTqK7QMKolW+SBDBh9q9Mc1m9Xo5Af9ZiNSX6fn2RBPZoSozzUPdIxymH0hJ1m1ruXj3uJjObUB3mrJ7/iOq1PfhAekN9Ie9AGyB63sK6pkJ7rMsR3rYi03ewqDL9MeHX1iqs3yHj2Jx86DmTPdJS7n/I7RtaVIp5uPKA/TAGRUddnaFNOepMlukaeCM7amt8otwe/GbPa2Q75qRO3ITgRzq0NaGO+nii8D2Jp82TX+2aQ9LUHHTYdA9i4gYEsSJ9M2QLrolNyw28s1HIDoUHXMlgURQK8e4XMjZk3NW9GSRJU4SlLguUdf0fTG1lEwy49EEfwVawGAyR3KUmLoJvTBKSbYAmQO4QoOHes6NHYJw9UJE4mQ3qjIIJuOOe7B4SNUBJuV1oQIL1A++JNU1Hi+FYG5SSI7vrHn2GgtKWnkRB0DZLB0nsWx5007pghyATcfS3iIL/16mFC2Pk5zq9huu7C8JMSZzBMyykrRQo/V2M4rwIvvVO33DK8jAwhp5Cll4nRJHimCbOfcptvde8NZQY7PZrcw8/hPPV44deI8CtclfRW8ZXP1ODJ5XOuW3jmmWfKoHqN6hQGpUcX/6nXPpSZsjJt5KoN9eWSOlee5EZPYVKeDIT60PGyVlQLBZzEYVDJFEXI+Ghn5Et4Ctd1EzoYZMc1K2QF5o3kVzzkdlSjIXLrGguzAtqDOndvk2kX/mjJJZdMlDX59RRfT1g5yEJVhsid8hhlGWWQZzpCG3HRIxmQjjTzVJx32pVrMugDHUs4kU8zFhS1zpML+JRNWzCa16YZD3gYsZsSh5F6MLrx/Qf6Ab9Vkg5dQ1HzZyDkRy7lBQt80jPajTBV0q7g1IjUUTW833DQ6TYTwW0EYSTmyhLuoiiSEQ3jVS9PYUZCLTcQgzHj/hKVTgBUgvnEHJ5ycrePu1XchULAhM/vq08AE2oVqkdhJEDpaRyEhrDo8XqnIalUPSi9Ku+radX+Br5GYNRBEXMTJnOOFL7wGpieAh6UgdHgPxhZi8CD3oAK1xgQZe6jLRqo3qW09IRyWgTVcJZx1aD1lPx2wRqFzUBRrhqN9PDNkDBaGrHG673bWuFDiMSrdxcMg4pP+Ob89VzEN1eOL4aPQGocOUx+Wj8w6mtEjFcOW30SfvlW/aq/9ZJQuxbNq3m367dpk6IokrUW+JM38i1/9Wq07QCgDgelxlDAxPsqkVcyaYqKPOncuPtIe6OAyIC2RtEYtbnjSc9Xm2Pgq2nV+y08PhgC7YCyJJcUNaMmfTImbZ0xCp381kur6odncg0HbUAadIU2iG8KXN560BS6uPSDdmi0S86NSugP8k0fkFFyBRPpCW8tVJuxAYJbJ8/6oJkCaRrFmO9XPu5MysfIwCn7aQdG257Wk5RZ509YOi6Hy0+jqUZtg389nPCu45DTqPdUl2REfdR7PxK/URsIvVy9UOTuexexjSRjYQ2J9aBUDHeVWHwVS/j5ExTg+D0Y1VYkRUhQGYLcgCggFUl4vR8sPe8IPaNjdKHBqnBGQm+dQjdUVwYCK/xwqLY8BFKlwkSaejXSKYpisi/e8UMaG+z8NlIwgjEXaRhfXayEB0HlryEQfkbGHKVy6JWaVpBOLbmQTINixKrv4IeyH35Rduen3ij5aETwzGFH8lQfqBkNYCT5DjcseaPAc7mtoVTrZDjpUIZGzPXm49UjJUmGc1qMR1EMvgYBsxzeU/2aanFjqfrM8sSYyLfaoxe+EVkX0cEwCsa3dqATofNCxkxx1VN2jdLjX1seI2dp44lOQMLRCdqS35m4c1nJr7arc2SKzQYIcXJYxoWSNxqRPmzxboqITNNDjFUOn5/aK+zqlUueGUvhpYn8rpKRUJaRek9GrBp+uL+VHQY6icON0yjcFI1eDOVPeCnYTK+88spQUSZ7j3mVTflQcJO9nORQWRrapJ9N+a+BMhI5MZVYFEXS28h+gz31SBgYw1eNUy9MeFMA+DQKKIrBG6jwjUjvhhDDlTAxFI3C1vqbztIzNNIxf21uNochqEYQGpjhr1GZ3heDDn9Koh7+Of5Ynqb5TGE1ItMXtenrKes9Ie8YTUZ5zjnnrGsohek00ibUpSfKv0fCp56rqSE939p4OT3GvvbdaN2UoTYnPpnRPobqqQqLtCHTTKawdLjUlx60+XLyRZYZHGFHSwyNclPK0rN+OJy0hGe4TLnozZN9OifH1dHStt2Ea92F2/calMUICv6MZw7fzKeRV6O2wV/nrjY/HVPtOPubfqQ7TGVlv2Y+R20gTDGYx0eUUyMlU1XKGNdgFMgirnlIcU37UIzeIb8JFAtqGocf4eCPuKVVJf7cwnlWyRy20QiB9V5YPJh/NHwVtiiK5J20vedXJY3FnKJpKT0ivXBuQ1hlxG8OL750srsoipTdGqH38vLMYfxGhNE7ypty9J7bu5yGZ/bz3vSRBm14bXiZw+b46kZZzbla4DUVpufDmJiiEFc6tSQ9DVH6+V1OGw/Zr9FTQ2QEGpGeam1c03/KZueUvBhLPVy86BkJjydkyoS700iP1Fy3toHs2lMvtXzCkGKu+iu7KVELt/AhY97DwlMcsig9aw8UhHf883tuvzNxI2nX+ulpmgvXzih34Rgm+JpCFL4oJpdffrVkDcvIwcYJskbpCmONQd1Ve+14lY/3mfjhj7/fKL/jh7i1YyPHzGs1jjDiIf7CMybOBpgaNcoxMvFeO/TEl3fm8I30tAcjam3c6FrnSjq1pPOjHow8qu+kiQ/Ev/bJLxPd06ht8MdrDpufvuOi/EYw8lJvRjjSymHIhLafZyGy/2ieozYQQ2Vmzg3AFn40cnOHFsj0wM0NGupZvDEPLy1DOn7Ib4t0DsZZN7AgatFHpapwykOcTHrH3ntnm2Be+NZ7sDinh6NHo5dgu605fmsSFq6lobEB04KU3jjjwb+WzHcyNoyDdw67WVC1yMaNjC7wYveHKRZ+hqz8TesQVovT5s/xoaLxpYcEHwaCItd7sfAsvPIqG0UtTWlbvGNEcvoEXHp6nnpwwlrw9V7DNUetZ2i4zW3NgrHQeIWpR6amCGnuzQtjAU6+dthoRHZxwF+dcQszFjJ1QClajPMRGRsBGA285HQpVTxlJZT9u+nJ6Fk8tRhLNtQ9ssnCLjEjJvVp6tLol0xpU4wCBU7xUoLWecQjT5S9dGGTsaBEyISpEr1ibZL8kClyIl3Ybrjhhsl3Q0wda2/qgcxIpyq/4vKrJcrShgv5GcFy28Wkc5LbizhZfuWr3OSd0tfDR9qCtS9thfIzAmEwTePq4eNJ50bH0hSWcPSCNQRlh6k4OoPwkr6OhOlMukB4+siUK0WLJ6N/ayPW67hNmfGzHsHdiOguGOb30tMu9PC1PW1QfuRVmSjuHHa0T2ux1jjslFRWW1190AiGOU2zM+RGObLfaJ8tMxCUMyE0FaMHxQ04vW0NmxAaRmXGKWUChfymtM3j6pHozRj6mbOz26J2OKXB6B34chMlaOitR0+IDNPkbeGNspGfkYnKzwKhp+ajK54ahryFqyXvpJGttUZsJKQ3kcPiVQ9E+ho2f7spKH0CS/DEowQINsNgEdKCrQavx6Fnr6zK4j0BoBD0zKQpbQZUuXP6dkpJT6/dNkLDV+sS3iMffMG738i7bCC565GeCUPiQzX5PSwZeHO3ykP47TaDAXcON9qnBm0qwNBeo2cc5Efgc5qm9NTvYMYth+3Up3ZAzq0bqUttAxklUbQ6OkZ6+KdYlN9aH9mBs56tsxLwYRDIsvql6EyFiofIkzqjWHSStEkyZEqITFFqDAD5o/CM6smQOiWX0qjKb5Z9/rWk963NZX/tW91lt6e8ya82oq0orzavLs0kMCzwUP/KRf5Nneo5wwxPOnnekwPGwk4/eoaBpCdsW4eT9iR9uxAtnNML5F7bMzqiaPEkDB0FE246ww5InSnuRqQjI02dPGEYHj1/aRVFkegZihvO5Bo/wo2FyAH+pUsO6MfMt3TloU6dpRGW31ioZQZCRRKE2sUXB+EUSE/c8C4zb94vh/WbP4HRYzCKIKR6SwSp2gCEA5adBuLbyw2cqlsPQgVRksKoQAJKAYvv6R1FTPHxa0SG0tLK7wle/u1JUcoD4Z0fg+M3Yty8y1QNz09jJaBGJbaQEnyNn1HVcKUhHMJzTl+DUXa7Uwip0Q78vEfqg7/fiLGr9uz41SM86CU53+G9fDPV8s4tzFipWn6GDu85TUNnu0fICIOe/bvtSf50djKW+UluyTiZyWVS7+pTGHVMnr1jQCgyO94oUUZAJ6Iqn2SbEREXaZNVN+UsLfJg2phxoowpz6J4dU0NL+QOGX0KX4/ILp7yO0raCCK7PaWBD0ReiqJIOk2UuEV3Mu0dErbWXRRFYhSUWdntdKJPyDaexcvEWBRFkfSk4So95dSm6IgqTqbZqnKmfsw84LkR0RUMqV68MMqe87bWgbeqe6j0pDEUFcXk5Tc9Vi0HI2UEQRYYzKHSG+p9ywzEUBnH+5EgMH5hKRy9UkN0Pb7x4ySV6zh6wEVRJAaR8htPfq6nVFgAABAASURBVCLvQMA0MwVtKthobTwRMXowdWd0pKPYDF6GNBCsejMyijS6EwGjPD0u88p5FDFeJTGdZdiuhztYT7bKHyNiOqp21FkNM9rfRq7NGMaPNv+IN/4IGBUYLVirMxU4nhxZqzGS0lYzH2OV/yENhCFnziye/YuABW1D+/FEwPSAYftIhs56d6YnKfNm82560TpNs9ON9LoLAVOipqQayWW7SqON1srjWOV/SAPRrsJFPoFAIBAIBAKdhUAYiM6qj+AmEAgEAoGOQSAMRMdURTAyLghEpoFAINAQgTAQDaGJF4FAIBAI9DcCYSD6u/6j9IFAIBAINESgww1EQ77jRSAQCAQCgUCLEQgD0WKAI/lAIBAIBLoVgTAQ3VpzwXcg0OEIBHvdj0AYiO6vwyhBIBAIBAItQaCvDIQrch2Jz+Q6aTcfZrenGy/dZ+IyQW7kIjH3zztJzI1cbOY2Tr8zuciPn3fZTxx3xrsfJfs52euaZ3llP0+8uKnR70yuanatb3a7OM2tncjv7C+MsNntKS1p+p1JnvLGQ/bDm2s0XJ6W/Xy4x82eypT9PF0nsOeee5Yf7+F2QZsrv2HEjWAHw3p4w1yYTMIIK072k5Y0pZ395Cnv7PbEGx7xyo2UoSUtpUGi9fKHJUzxg2ANc7xxIzyLq464M5EVZc1uGMCiXn3DLofzhG29+q6Hb7fKM8xgp7wIprCFMTeCvTrwjhuJIy6Z4c5EpurhTQZzGLIJwwYi0NPefWUg3ODoOwqZHI93fUN2e7rt0pF19/JzI7e8uoXVFczcyA2zrgn2O5PGzs+77CeOC+9cwZ39XOXtozLyyn6eeHFlst+ZXBHhvv7sds+9m16R39lfGGGz21Na0vQ7kzzlve+++6bshzd3FblGOfu5CpwBUqbs5+njQi4o8xv5yAq8YMSNYMevHt4wFyaTMMKKk/2kxU/a2U+e8s5uT7zhEa/cSBna2WLr5Q9LmOIH5frGGzfCs7jqiDsTWVHW7IYBLOrVN+xyOE/Y1qtv8Wvx7VZ5hhnslBfBtF3y3E656pS8+spAuKdEg8ykZ+Cyrez2dHOpXpvvIHAjl18RzKqf+/jdc+J9Jtdy8/Mu+4njY0SuY85+q6yySnLJm7yynydeXI7odyYNnuLPbreYuh4Z+Z39hRE2uz2lJU2/M8lT3njIfnhj2Nx/n/1cp+1uGWXKfp4u/3I1st/IVcsaKIy4kTLDsB7eMBcmkzDCipP9pCVNaWc/eco7uz3xhke8ciNlaGfjqpc/LGGKHwRrmOONG+FZXHXEnYmsKGt2wwAW9eobdjmcJ2zr1Xc9fLtVnmEGO+VFMIUtjLkR7NWBd9xIHHHJDHcmMlUPbzKYw5BNGLZTrjolr74yEJ0CevARCAQCgcAYEGhb1DAQbYM6MgoEAoFAoLsQCAPRXfUV3AYCgUAg0DYEwkC0DerIqF8QiHIGAr2CQBiIXqnJKEcgEAgEAk1GIAxEkwGN5AKBQCAQ6BUE+s9A9ErNRTkCgUAgEGgxAmEgWgxwJB8IBAKBQLciEAaiW2su+A4E+g+BKHGbEQgD0WbAI7tAIBAIBLoFgTAQ3VJTwWcgEAgEAm1GIAxEmwHv5eyibIFAINBbCISB6K36jNIEAoFAINA0BMJANA3KSCgQCAQCgW5FoD7fYSDq4xK+gUAgEAj0PQJhIPpeBAKAQCAQCATqIxAGoj4u4RsIdBICwUsgMC4IhIEYF9gj00AgEAgEOh+BMBCdX0fBYSAQCAQC44JAGIgmwB5JBAKBQCDQiwiEgejFWo0yBQKBQCDQBATCQDQBxEgiEAgEuhWB4HswBMJADIZOvAsEAoFAoI8RCAPRx5UfRQ8EAoFAYDAEwkAMhk68G28EIv9AIBAYRwTCQIwj+JF1fQReeeWVhOq/Dd9uRkC9om4uQz/xHgain2q7S8p68803p5NOOik988wzXcJxsDlcBC655JJ02mmnDTd4hBtnBMZkIMaZ98i+RxGYMGFCeuCBB9JTTz3VoyXs32Kdd955aZlllulfALqs5GEguqzC+oHdqaeeOs0222zp3nvv7Yfi9k0ZGf3nnnsuzTrrrH1T5m4vaBiIbq/BHuV/hRVWSMcff3yPlq4TitV+Hk499dS0wQYbtD/jyHHUCISBGDV0EbGVCMw888xJb/PRRx9tZTaRdpsQePbZZ9P111+fFltssTblGNk0A4EwEM1AMdJoCQLrrbde0utsSeKRaFsRuO6669Jyyy3X1jwjs7EjEAZi7Bi2IoVIcxICiy++ePr73/8+6Vf873YErrnmmlic7sJKDAPRhZXWLyxPOeWUackll0xXXHFFvxS5J8tpcXraaadNb3vb23qyfL1cqDAQvVy7PVA2BuLqq69OL7/8cg+Upj+LcPvttydrStNNN11/ANBDpQwD0UOV2YtF0es0knjkkUd6sXg9X6YXXnghqTsG4g1veEPPl7fXChgGotdqtMfK85a3vCWttdZaKXqf3VmxjMJSSy2VFlpooe4sQJ9zHQaizwWg04tPwcwyyyxpqqmmahKrkUw7EZhiiinK6aVpppmmndlGXk1CIAxEk4CMZAKBQCAQ6DUEwkD0Wo1GeQKBQCAQaBICnWYgmlSsSCYQCAQCgUBgrAiEgRgrghE/EAgEAoEeRSAMRI9WbBQrEGg7ApFhzyEQBqLnqrR3CzRx4sR0ww039G4Be7hk9913X/rHP/7RwyXszaKFgejNeu3JUk0//fTpqKOO6smy9XqhLrzwwuRG114vZ6+VLwxEr9Vow/J0/4t8qvo///lP9xemj0rg2vaHHnoozTXXXH1U6t4oahiI3qjHvinFOuusE5f3dVlt33nnnWmOOeaI0/BdVm/YDQMBhaCuQWC++eZL1iKeeeaZruG5nxl1yeLdd9+dZpxxxjgNPwZBGK+oYSDGC/nId1QIuDZ61llnLY3EqBKISG1FgCF3Wd/cc8+diqJoa96R2dgRCAMxdgwjhTYiMPXUU6cZZpgh3XvvvW3MNbIaLQJPPvlksoPJyG+0aUS88UMgDMT4YR85jxKBCRMmJIpH73SUSTQ3WqTWEIGbb745zTvvvA3fx4vORiAMRGfXT3BXBwG7YcxrMxJ1XodXByFw9tlnp+WXX76DOApWRoJAGIiRoBVhOwIBHxCaZ5550o033tgR/AQT9RFgxNWVBer6IcK30xHoAwPR6VUQ/I0GAR+h0TsdTdyI0x4ETjzxxLTBBhu0J7PIpSUIhIFoCayRaKsR8BGh/fffv9XZRPpjQGCnnXZKCy644BhSiKjjjUAYiPGugcg/EAgEGiIQL8YXgTAQ44t/5B4IBAKBQMciEAaiY6smGAsEAoFAYHwRCAMxvvh3d+7BfSAQCPQ0AmEgerp6o3CBQCAQCIwegTAQo8cuYgYCgUAg0K0IDIvvMBDDgikCBQKBQCDQfwiEgei/Oo8SBwKBQCAwLATCQAwLpggUCLQXgcgtEOgEBMJAdEItBA8jQuCxxx5Le+yxR1pttdXSWmutlU4++eQy/iabbDKZu/SMP21H4LzzzivrRv2oEwyoI3WV3fyCOh+BMBCdX0fBYQ0C008/famArrnmmuSLZWuvvXYZ4qCDDko+TrPKKquU7vgzPgh88IMfTOqIoVAnuFBH6mrHHXfkDOoSBMJAjKaiIs64IlAURVp22WXT5ptvnh588MH07LPPlvxQSAcccECpnEqP+DMuCMw000xpu+22SzPPPHO65557Sh48Xfu98MILl+740x0IhIHojnoKLusgQAndf//96ZRTTilHDrfeemv68Ic/XCdkeLUbgSWWWKI04t/61rfSE088kS677LJy+q/dfER+Y0MgDMTY8IvY44jAO9/5zrThhhum008/PZ122mlpxRVXTPGvMxB485vfnNzmeumll6YzzjgjvfTSS+kd73hHJzAXPIwAgTAQIwArgnYeAl/+8peTtYhzzz03feADH+g8BvuYo6WXXjqh/fbbL80+++zprW99ax+j0Z1FDwPRnfUWXP8PAfPcH//4x5OF0VBA/wOlQx5FUaRtt902GenFd6k7pFJGyEYYiBECFsFbi8BIU5922mmTUcS6666bTGuMNH6Eby0CNhN87WtfSxMmTGhtRpF6SxAIA9ESWCPRdiFQFEV63/vel9797ne3K8vIZwQITDfddGmllVZKb3zjG0cQK4J2CgJhIDqlJoKPQCAQCAQ6DIGRGYgOYz7YCQQCgUAgEGgdAmEgWodtpBwIBAKBQFcjEAaiq6svmA8Eho1ABAwERoxAGIgRQxYRAoFAIBDoDwTCQPRHPUcpA4FAIBAYMQJhIEYMWWsiRKqBQCAQCHQaAmEgOq1Ggp9AIBAIBDoEgTAQHVIRwUYgEAh0KwK9y3cYiN6t2yhZIBAIBAJjQiAMxJjgi8iBQCAQCPQuAmEgerduo2SvIhB/A4FAYJQIhIEYJXDNiLbVVluVd+S7phrdfffdaa+99prM79prr02//vWvB/xmmWWWdNhhhyXfP5hrrrkG/PfZZ5/0l7/8ZcAtvb0mpeWTnEsttdSA/0ILLZRuvPHGtMIKKwz4rbfeeuk///lP8k48JI64q6+++kA4/s8991ySl98ID3jZZpttBsK9973vTRdccEH6+c9/PuAnrI/6IL8zCSOsONlPWtKUdvaTp7yz2xNveMQrN1IGZVEmbqSsyuwdNxJHXBhxZ2qEdzPqO6fRrvKORb7IGFnLuJBB2GS3J+zIrN+Z5AlrmGc/dUE2XaiY/TbZZJP03//+N6nD7OfJzzu/kTi33357IhPciKzAUF7cmfBy2mmnTSZz5AvvOYwyKdtY5CvXYz88w0CMYy1/7nOfSz/84Q8H6O1vf3vybYOqn69wUWbZ75BDDilvx5x//vnTgQceOBBXPAo1h/Pk95a3vCW5bpkb7b333mm22WZLO++880DcrbfeOrk22zthkDjibr/99gPh+LuVU7p+IzzgZaONNhoI5zOT/Kp8C0tBI78zCSOsONlPWvyknf3kKe/s9sQbHvHKjZRBWZSJGymrMnvHjcQRV7rcmRrh3UwxUbZ2lHcs8uUGVrKWcVFPsMluT9iRWb8zyRPWMM9+6oJs+nBQ9tt0003TVFNNldRh9vPk553fSJwZZ5wxkQluBDsYyos7E17qyRfecxhlUjbxRytfzZSFTk9r3A1EpwPUSv6WX375tPHGGw+Qq5GXWGKJAbd3Gtt888034KdRaAQa3Gc+85kB/8UWWyzNMcccA25xpTX11FOntddee8Bfb05DWnPNNQf8PvrRj6ZpppkmeSceEkdcPTzuTG94wxuSvLIbD3hx73/2+9SnPpUokwUXXHAgD+/e9a53JeR3JmGEFSf7SUua0s5+8pR3dnviDY945UbKoCzKxI2UVZm940biiAsj7kyN8G6mHLSrvGORLzJG1jIuZBA22e0JOzLrdyZ5whrm2U9dkM0NNthgQB4oad/vUIfrNa/nAAAQAElEQVQ5nCc/7/xG4rztbW9LZIIbkRUYyos7E17qyRfecxhlUraxyFczZaHT0woD0ek1FPwFAoFAIDBOCISBGCfgI9tAoPsRiBL0OgJhIHq9hqN8gUAgEAiMEoEwEKMELqIFAoFAINDrCISB6N0ajpIFAoFAIDAmBMJAjAm+iBwIBAKBQO8iEAaid+s2ShYIBALdikCH8B0GokMqItgIBAKBQKDTEOhrA/H9739/3Opj4sSJ6fDDD0/t5OGhhx5Kp556atp3332TawkGK/wNN9yQbrvttsGCjPs75fnDH/6Qnn322Zbx8thjj6XTTz99VOm3s25rGRwP+br33nvTz372s3TQQQelxx9/vJalydzdIF+u+PjTn/40Gd/tdvz+979P999/f7uzHcivrw2Eu2UGkGjw48UXX0wnnnhiuvDCCxuEGJ33888/n4477rg0HB5Gl8PrYz399NPp0UcfTb/73e/Ke3BeHyKll19+ORFKjWPuueeuF6QlfnfccUfac8890y9+8YvXpe8OJlcyuHLBqVonbW+66abkxC43QyvM6yI2wUO6sJg8qeG5hlO36uSXv/xlUp7hpTq8UOMhX2TnuuuuSxdffHFDoy3MeMjX1Vdfndzx9Ne//vV1AKrjevI1zzzzJPd1HX/88a+L0y4P7eLJJ59sV3avy6evDcTr0KjjQUC++93vlgaCINUJMiqv97znPeW1E6OKPMpIrhdwaZlG2igJyvDSSy9NrjFw7UGjcM30f+SRR8rLAn/6058miq2a9iuvvJI0alcrHHzwwcldOnvssUdyfcIUU0yRFl100fKakFNOOSW99NJL1ahd8VtP/xvf+Ea68sorS+PcLKbHS77cb6XOGpVjPOTrgQceSLfeemvZ8dHhq/KG10by5WqX1VZbLd11113poosuSsJW4/bD7zAQQ9Sy3pALxPR6aqdlGIxrrrkmnXfeeeWUzW9/+9t05JFHJo0gJ3vLLbeko48+upxKOuOMM5I4+V1+6kWaxjAloTece55unOTnHaXtHXeVCL90Jk6astL7dikZnvO0C2NgqggPeLv++usFb0g/+MEP0oQJE8reuUCmcc4888ykHH//+9/Tj3/843LKxa2b3jeDjARcqAbn2vRgc9ZZZ5W4LbLIIsn9TB/5yEdSNl6eH/zgB5OpJoamNn6nu902ytj95je/Saazqvw+8cQTZW/8oknKKdfvMccck/79738PBFMv6pZMNJKvhx9+OOkFC6P+pCUB8sKP/CK/q0ReyCvDa0roiCOOSD/60Y9Kg81PGp4U7E9+8pNy9JfT9q4e1coX5XvOOeckPeU///nP5U3F559/fsMRSL00h/KbddZZy/vDyEpt2KHky8WP8847bzk1O549+Vq+2+XuRQPRNOyeeuqpUvG49dHFbscee+xkaWt4lPc3v/nNUoAoa2E0MsJEubrJ8l//+ld605velHbbbbekEU+WyCSHnoqezd57751+9atfldcVT/JOplQ0YkL8z3/+s7z90iiAQj355JPTJZdcUipKvSP56lEzDKZqNDLGgVH79re/XfbQNRCKVNr1iBJgDJZccsmB14zLd77zndLAGabfd9996etf/3p5tfhAoP/90NDXXXfd1IiU7X9Bh/144YUXElxPOumktOmmm5Z5w7WawDvf+c5yKuDiiy+uenf8bx0J9QVPuNZOY5IbCtlV58pmetBvRkLh4DAc+SJ70jdSUYdkWfzpp58+GR27JZcMkTfyxVAbzZEd4S677LIE/5lmmilJx024f/vb37wqjQX5KooikVN8li/q/KknX9LZe5Lc6/yYZoMJPPyuTWI85KsoinK0qmOFt1qeet0dBmKQGjYiWGuttZJbKz31fizE5Shut3QbqQb3iU98In3pS19KX/7yl8vekMaiAevh6fVqyPNMmtOsp6CnnHLKtM4665Rz8JTCDDPMUGah56PButFSGptttlkZbuaZZy4Nzve+973kBksjDXfkf/7zn0/y+cAHPlAaLDwwbgzKDjvsUCrYL3zhC2Xa9f64s98UD0WR30tXfqYs8PB///d/af7555+sF5vDrrjiiumoo45qSG5TzWGH+6TEDj300ERJbbvttqUBZbD0bHMawujpjfeCYuZnuE+LueplmWWWKXu4FHg1rpGFdSD4kw/z5J/85CfTzTffXAYbrnyZVhTXDasTJ400yZUEyK1vKqi3LbfcMrnpVBgdi4UXXjjttNNOiYG+/PLLk1Hb+uuvn3aYJEc6NGeffXb5jsx/7GMfS5tvvnkpe9qBtOtRPfkyRciAffjDH07kd5dddik7SMpWmwY+x0O+tEfTS0bQtTz1ujsMRIMa1mu1eOiDJXo5DIEeuB6dBiSaHrveFwVPUeff1i0QRaonpFHuuuuuyXSUIbm4tSQtjUxjNh2gYepxa6QapEYkjCG5aQINWs+ZEdCA9bo0Ng3NyKIoinJO3ojlQx/6UGlQxNcLrM07u01jKSOjlP3kLZ5GomepjEiPU+83h/M0atLrbESPPfaYYCOioigSRQYXZdbThGPVUJv39l4vb0SJj2NgPXmjRqNUozTXmdutYi0lswV75Ppy5YO7+iGbaCTyRX523333cqpQh4KB1QHaYostUlEU5Ui0KIqkl29TBsWvo4A/o9UvfvGLyVSeq7uNIrQBeJNH/vhE4mT+a5/15EuZ1K86VLY3TRppm0KTR2388ZIvnQ+kLdfy1OvuKXq9gKMpHyVuO6i75c0Roz/+8Y/p/e9/fzmXO9yhpkZsQdUcummXlVdeeVB2KIGvfOUr5TSU3hbD5MtcOZI56f333z8Ziaw2afGM4vaOAuFvLtguEsRNqDUqDVe4VpOeLawaEaU4Vh4YwNlmm61ckxhrWuMVn1E3kmRwM1YMroV4XzsbriEdqXy9733vK6f/fGHNmgP5hmXGgdE1fWS0zGBlfx0RfJIrxEAbqTJwwoR8QaE3aYreLNbYSnXPPfeU897OC1hPyGSKSePVs9fDHyoXi4sMjbWHpZdeOuktDRWH4tfbM91gaqka3tSKXoxRhR69Bo1XUyy2rjIgwlsbMRzGo5HNVVddVU4HeDcYmU4SxzTXYOEavfNRl4xVvafpi0Zxh+vP4FFqs88++0AUPKPBRkcDgTvgh166XrMppipOe+21V7ntWYdiOGyORr6MwiwIm5700aScj00HRrlzzjlnMpVpVGwk6skAMChGHcLfeeed5RkZcsfY5U0V3g1G3SpfOozIVO1g5evFd2EgampVI7CjxEEfw97qaz0wvTxK35y4YbbGZr4UCUuBUVZID8ucvgal16WHbehs/lbvz/AcGcaLi3wzd4011iinh+zs4Yc0UOcmTC/5Ohc/Q/9nnnkmMSpGHHrXtoGabpK3HipDI94JJ5yQ+Bnmy8/aCB6lk8k8szC+6Zz98M8IWSR/7rnnkrlYeZpe8juHG+sTfvK23bOalh616Q3TLwwit3lzBjKHY7Qt4Cp/9uvUJ/lwmAx/6scz0yqrrJIYeTuC8ihVh0B9IOHEV2+wQupnJPJlR441D3JsfUOayCYHeeoEUfxkxAYJbWDVVVdNdsdZQ9JJsd3Y6JTC33DDDZM4FqftIlN/2g55wZ+0M9WTL/WuXZiW1J6QvJHfOe5Yn2SEkjctVk2LPA0lX2QLVUdV1TR6+XcYiJratdBpDcAuoNyQc5CPf/zjSW/K1I7FWsJF+TIqdg7ZFkhBC/+tb30raYiUvREEg0AQKQUKXoMjdOirX/1q0rjEk/4CCyxQfpoxK0HvTjvttKRRfvrTn04WEJFhv+ml5ZZbrmykGr35Y4uGpqaKoih7g4yEuXv5L7LIIuWCo56icsgz01JLLZV8jtGcePbTq9RY7dZSvh133LHcF27KjSLL4cbypJi22267cmutaSgL/coszcUXX7zsrZqik78pEOtCRVF4XZL1HrgxlKVHB/+xyHrFFVck61vVXUs6CkaMpjHJBNy32WabRPkz0EYbFojJp/IeeuihaaWVVkojlS/yZ82A0je6BBX8dXgYfTvYyBbZ1amBq80J8qfML7jggnIxG5/kh7zjwaiW4fAJUYbAaM576WeqJ1+f/exnE4PEyGhz6pBRIlvcOe5YnjpP1l+MOrVZ0745veHIlxG1aV1lzvH65TlFvxR0uOW0CKeXgRiBajzzxvwzeZ9/682bl626CRUlrvfPuFgQdJ6CoJm+ymEp7zx81Ts0RWS0ojHL3zthcvjqUziLe9I3MrGXXE+Pn7jSsODIHy+bbrppecWHnVkavzBVYsysfeip8hcn56e8tW5hxkrmwo3acj7KqszSpVQoUgvxjK7pJf6Z9ArN31vfgXf279QnDHM5yVrmU2+eQszvyJNzB9mt584oVN06BOpjJPJlSoghoBizAq/FP+fhiT+dENNO6kAb0CHhjxgZ21wZds+dd965vMqFEc/pC5epVr7kkQke+bcnd443lqfpXRhJE2l7Ob2h5Et7nDhxYmmIc4ctx+2252j4DQMxGtRaEMe8tF6aob4ePMXfgmyGTNI0DWVlyqB2imDIyOMQwMjM9IttoIzhOLDQFVmqTxsXjI4ZCVNN48F4t8mXzod1GAv3w1lDHA9MW5lnGIhWojuCtA3fDdf1lu1HH6/eCiW70UYblYfyTD2MoAhtD2pNwgKp/fmmzNrOQBdlaC1DB4QxtW6QR5jtLkI3yRfjYIrPtO54tcd2109tfn1tIPKJ1FpQxsO94oorJnOddkg5h1AUr82xt5sfysOUjX327c57JPnZfulglumoomgNXg6VmV8fCV857IjkK0dq0dP0p7UNUzyDnVVoUfaTJdst8uVwKPnC72QFaKPDlCQ+2pjlZFn1tYGYDIlwBAKBQCAQCEyGQBiIyeAIRyAQCAQCgUBGIAxERmLQZ7wMBAKBQKD/EAgDMUSd+8jIEEEavrYb6R//+EfK5LRqw8BDvLDt1Glp2/KGe9K2muSNN96YnDUY6VZQB7Hc5yRfWy+raebfthDav25HUfYbydOBKNskXdRm3cM2SpfS2as/knTqhXWi3B1XtmDa3lkvzGB+yuTG08HCNHo3FtlxoDLLjaezD6M9mOicjlPRdhA5aNmI30b+1sZsDXU+oVGYRv62xtp27ZR4PfzhS3bIUKM0BvOHiYVk9et8h3M8rqtRVtu1B4s71DuH95yZsGkDn0OFH+l7deGWg5HGa2f4MBAtRNthqI033jg5fET5jWVXkOs3LFbZWTEali18O4080ri29lkEpmQ0xnrx7SByjYb98vXeD+XncjZXPtuN5MCWXVwMhQNYQ8Ud6r3dJ8rgsN9QYTvpvQNpDgw62OgGXudYnPkYDY/Ou6h/inQ08dW/Lc/OBIw0vkV+HYBGcckM2SFDI01beEbHoTrGyyFCB1bdaebAXl6MF240JM23ve1tA4dYR5NGt8cJA9HCGnR3v90jEyZMKK/y1sMZbXb2YrvaYLTxQBzm1wAAEABJREFUHWhCI43vsBMlS8k0ikuZU2YaVKMwg/k7Na2XSplo1DA74IADkiuqB4s3nHeuykbDCdtJYVx97fQvBWrkN5Z9+Ayksy2j3Y1D9ihdsjBSjBiXwfIlM2SHDI00beGNcF3rIR3kNLrOBuzcWCDMaIlxYFhHG78X4oWBaHEtEjJ7vynnoijKT5dqEKaJ9ttvv+Q0rOsrHnvssZITvS2HmtzL49Swe4dMN5QvK39cO054Dak1EFdfGGFkdw7qSg9XlbtHxjRO9vd0Z45T1u5/Msx3rxR/JE2NDX96sK574F9LenAO9zklbo+9Q1gugjM0d1WDC+F8n0J5la02vmkznzd1wtW15IixcGrYSEJ46Tpdze1Uq2s3lAlO3hvdGK3pbeMXL6YHvOtmyobZk3J2kypZgY3yOuzmBH1VPuDjnIMtwLCvN+KEmzpR79J0RsKp5ezOmJlSdIU85e0GWKOI/M6IjPyKQ7ZMEeX6VV+uCsGDa1/cMpzj1T7Vv/aAJ++cA+ImL9JXn8qc24cwmfDuFLhrYHQm8GKk4rR3xoVsuIeMTBjBk3e4md4RFs/yzu0NDs7W5Dz6/RkGos0SoMdjPtjdSq47cJunxkDYsUKJOzBnzpeCJewUgndVIugUsWs5NFwCbh42u01HSMfdTNJgUFwEl9NwMM/1CaZxKAi9LXOtGpQDaOZx3fVD4TAULujLcatPayNGABSRxsYtbVMkGq67k5TTCV5KpRrX7zXXXDOZGnD/j/Kak1UePOV5X8rRfLILBpXHnURGU66fkIYG7WI59xyZomLcfFcBBt73ChkJ+KoavPTqjz766EReyJIyMuLq0FQdf4aWYvSuSu7pIg+mDClJd3/5KmJ2q0f4GcUx/q5wcbeSepGOOqa8jfjIivuUnK+QPzmxZkPO1ZdRdD3lLh1rckYXLvgTnp/nYO1DmEw6BJQ+Q+gup7xOQx6t/ylbURTJ1CoZIR+MJ4ycUcGXsyHal84HmWNkfGRLRyfn08/PMBBtrn1CTQhdDaF3pfdsCoSwYkVPTRj3x1DabmbVQ/OulkwbVP2qbg3HyVmNnL+7l6yF5PB6ahq6S+J8OMYUkl48JU0huBjQJW0asMvXfN0sx60+KQ7XggjPX9mMZDz1/CxuW3S2zqDBCjMYMQbmo6VBIQpr2onbdIu1HJhZhMyjBDxo9Hqb5tkpT73Y4eQn/W4ho0O9cvLAaMPBSIACVAYXRxqxMhBGn+5FMhfvXS2pn4yvd1U37HxyVP3J0xSpg5xkQViKX4eAcnWhpfCMuUvxKGZPd36RCTLnGnjxasm0FVlXv/kdN14atY8crtETjzobLgAUhpt8GoU5dAYz8sjYMUZkxRqIkSvZcQ27jhQSv98pDMQoJUAPzBF8ZM5cD3e4SWmYKIdnHBC3xmcu1W8kbXn4PRLS89cANJYcj4LNvylXDZNyRUYgeqRuvPSOcdJ4hMcrA+L3cEnDLIrXTjfrzY5VYVf5xwcj6EmBMSCMqekMU3r8O5UuuuiipE6RtQYXOA6X16IoUq4XcWCaDYSdaub8+SNGBCZ+j4SMQlFVduTJeEtHD92TIic71taMZilZ05Tw1+kRpiiK8mt1fg+XyBvK4bUNlN2jeeK/KF6TR5jBjkzpjJmy86U9Rm006fdqnCkGL1i8bYQARWqaA+ldE7RGYUfiT6nr1ec4ejruy9dLy37DeZpeMWVgCqBReHPXlEgm20oN08WlIDwbxe0kf9NKFiZ9DMd6ifWJTuKvlhe9W3KD3Hqqd1sbZrRuW2KrcU23oarfUL9NMSHy0Sgs+SAvWXZMVep1kxkj03rTiY3S+n/27h1Hih4IALDrHhtARsgNICAgIOMhSBAiJiMlICPgECCRAQEJARJCK0HAsX6+HmqnmZ3d2X96Ht0ztdqabr/tcrXLrrLL+/TXDqtSYrYXL140K9N91mdsZReDWLNHLIHJVwECoyxblpUB3yDvKdwHRM5v9sINfIzAOyWZGSbTz2T5VhT0E2Zk0hn0M61ZlrzNzimcDe7CyU8xMCsR4iNuadRBuHzY+zfbc8eC2RSguDNgWT2QYVtyq690yvGUj3r2IcPElT+3MryLp23A+zIwsKij/IVLpxzuzJObQpxbHPmJx42hYtAG3Iho4qkDnIjrHXgfA5hxoxtgW+ZFg5L2a6P2eGorvz5u+SUubDTADKwETShMDphRp5SFP3lICwdWhBHR3e0B/+LLy8BuQ4XVwefPnxs9AX/lSk/HID+rCRsglEG8RGdhNWHjBDdRpTTwrkxPdVB2HzJv4fy5xe/H1T4gfBGUYUUjvfoJlwcQxi0MDj25xZOfONqLEVotWWVgbsLyKQ9uIO2xQTGILfY4w3sGaAOYvdpEImnjn7yYm3LVB2V5y01ZRpbuEiHKWPHI8Q12lGkGUgpfjINugWjF7JnM2MdKtEPZhmFRNLv9ziBEYYyBkE2TH5Ndu0CIQtEskDIZcyCiIJNVpvR2D5EpR0SjRzDj6qPMAKKNzJVrGxm0g3WUzdlmbdNGbe2n9a7NGBNmRNFIuU1UIo083XeQbkxLO124Q1Hrg+fGCDFJ+SgXruCA8jPjig8HypwC0BFRqhrAKFSdg9BWosyvX782bv5EifDDzbAcvRbdk8uGKFttjzWo6yNiGvQgbwyAboByGt4dKCRekT9mizZMTNCAtPqJboiyFw05BKif0QpdhzJMYugs6B/0hfKVhUa0Aw0s4h7N6GdliMdNF4bulYlmpEMP3P306Fnd9bG6YFLqYWcUhbkwaeRN9ChvkyJ0gCmiLYzAig6u7WZC4/K1KpVGWjSNWcq7X/4xvBeD2GIvEx3Y4WGWbkeQGYoPCKH6sLidbDYIW5FwU0IK9+E+fvy42fJHxm7GZhlsV4lTxuIazCkJ7WhifVUe3MrysfOXl8Hex42RuFHLu3ArHx8JRiSuAQY6hIvL/+TkpLsZTzq7RZQpToKZKEWocG2j5MPkyKQxMPVUL23U1kyXT+HSm/VSHqoXsL1XnlZC6fYRY54GMEppDJjbashtZvBD3GeLpbMDFKuUttoBDGBZ7tif2kyEQzaOhih0tRUebenk1jYM3gDNDS8GRbin26CUdTlVRDQze4M2nZa8MVU4Q2fwjqYwoOxjtICW1AFD0B/6yCRCevoTg7eJhd1w3PpeHeDeNmcrOqsNGyWktzJdxDua0c9oAC1xo9mLvo9+eito8dUbzcFHRDRKfHjSrqQvkxW4MIGiqNY2kySM0m4/K3f1I6Z0MZXvCeOAe7sDtTsi+sUfxXsxiC12s4/Mh5Ng4M13z2VujMBAauYnvUFBFX3Q/KQDmAZ/g6JdK8QWiN0M0gctHx+DXSTCPYkybDnFuKT1MfuIMtxpbf7AwKx8Zw7kLa3BV57CE3KwUCewrE38EzJdPhfjq6e2ZXx16LvhwIee4dza66PHiMS1qvLBw5lBIOPajZXljv1p11nW21ObtdU7WOY2wKIBoiYDvVWkdlIaw490QN78MXCrR2FwaKMCPwMvUIZweJMGI5a/tAZeSukMN5jyB96lEeYchbTywkCE90F9Eq5CS/20JiuZ1lOZ2qr93GCRvhbd2oO+0Y5viZjMGQrMAv7kAeQp7375x/BeDOIYernaWBgoDBwjBga3uRjEChQS16yIUsEHjAGzXgrMdZpYtLMO1o4njd12VjBjbnExiBW9Q+G2IkoFHzAGyPaJXtZpYtHOOlg7njTEu0R6Y25xMYgx907V7aAxUI0rDIwdA8Ugxt5DVb/CQGGgMLAnDBSD2BHima9wIGdHxV1ajENI9oOz1umA1KWRVwTaG87YoDMYK6JOMlj7nA1Yp/LOAKyTbhtp7Pd3XsB+/iH5O1zmfAnwPiSvKaYdQg9TbG8xiIt6bcP+DgMxmbHhbNfKzqlSh86cDXDQaq1M/iZyuMneewfT/nod1EP7mLJep1HODayTbhtpGNZzbmQd20z9+phcOGgGvPfDjuF9CD1MET/FIKbYawPrzJSCfelOIg/Mqjl8xgKtvfRD86r028OA8zQOrg0d1J1/cBAReN9ejSvnMWCgGMQYemFFHZjXIKJiIsPTCkAST2YI2KJhXoJZASYGcuBnP4bpAP5ESkwtSBcRzUEo70D+bPjI35P9GeCdmQGzT2Uxh8FNVMadaQ06KW5QpnB5qQuTBuIVXB0DcKlP9Rt8EwPyk4N+1qdMVzAvIlxc9oWEE4GgEfhn4kU/8neILg9Cyiv7SHr9K458pRMmDn9udMAumL7V1/o+aUw64itx1Fedskxhe4IqdkMYKAaxIURuKxsfPFMCTBo48s/EhBm7D5j9HBfCvH79urEZw3SGLZm/f//uqvPr16/GJo90TGkQKTGE1gX2fnzcLFmym89EgoEBeGeCgfFAZbokhp0fl8OweSQvNnJYUGW7Rpb8mW8QlwkI9nH4F1wdA0SR7Gcx5qff9aGBGr7pEGyfff/+fWPChYkJYqO0kcVshDRMpdy/f7+xadQW/jAXZjKcIHZqmLhRFBdLOY2M3gz26EY/ogN2wDACdp+Ux5SF+phcMNciHpMa6Gyo2FJdCsaBgWIQ4+iHC2vhYzbQs8vElg4GwBgZWSjTFwZys0cfto+W+IglTRmSEzNfwOqmwVo6qwBhfWBi4M2bN40ZArbx3RQGvLs0hi0nhswwIPdgMNTGnEJENGILA0fmd3p62tnCYfvGQOKgWYbV82oYoK+yKmAria0lgz/DeRHR2B6yQmASgl0lgzgDegzMyR3jYDrFIM8YnxsL+ffB2Q52mthQ0j/MmwhnysOhQBMJqw+0pR/VgVkN5lvQBRMtVhHS6HsMjXFJuijmNfgXHAYGikGMvB/Zm8EYfKA+egbrLOGBMPaGHLZhN4acmdsAo1lmfgYIO04YcMNUlol8iB/YLGIYkOE0AxLGxOS4FQvbTcBF8GaQTghbbbDLZKDq26hhR4qJadZTxTHoqEsf6v1yDMAZRswE+9u3b5sVodk6fOcA7RQue1n6nWgIyPXnz5+N7SNGHa02UqworA/oBAPHBNwgKMwEgpE/fW2yYGWBboim3PdgssEgnrTiA31vNYs5YGoPHz5sDPQJK5g+BopBjLwPfXwGW6IkHyqxw2KVI+ZWJq0mUj5Mdv3q1atGBEBM4Qa5xbTpjojGkiVm8fHjx2brKoNvFJFmmcQHDPcRJ1lJ2NaqrEyfT3GImMR/+vRpK3FDYubqT4M2/OlrVkUxjMXUEfM+pxtAJ562shLzmOFbNS6m67tNKNAF8SFdBMZupSqOVSWRk8kC5kBUSP8grA9WI1YxJikssGJoyu7HqffpYqAYxMj7juiAqMGyn41+s7irVtmKICKalceNGzdaxHxQWZaHj51IidzaNZi5M4kexOqDVUv+ViFWNWa1i/lgCEwIfPr0qZtJEmNQrC7GK/dyDGDu7vugKCYuIjpcHvO8r00BmINBH70QBZ2P9a8PhqBvDfJm/xlK2bmY9scAAAZPSURBVGylgFFh+MSXi7fViWslSw9BxKTe379/7+hNWMH0MXCeQUy/TQfVAgOGlYDZup0k9As+SE+zOx8yUUTO7oiGvAOzfDNLAzyxkwHdAO7MglmqsBRNJNIoLe1wIr5iApq/AYTIgqybP90H2bMZqzA7qYgyuIkpXGhjcCLPVkeDiHwKVmMADuEUzvS5i6EwC4M/PYS+hmsgt35/S4c25KFfiQPlIx3xD3pAT/pEWsCsNSbkchxPfsAGCJMAzJ0Yi3hLWWgG7QDvynS3AqW2vKwklCWPguljoBjEyPvQgOziGzNDIgDvPn6DvstcDAI+ZLJiegqnft0axk3EQFFt5UF2zHIkebPBhT7BQEHRSRGZaCCGIlqyeiBaSn9Mis18F6coQ57CrRYwH/kYyAwadB+YiB01xFv0FJlPPS/HADGiOz3sWnKnhX7GaDFnq0l9g8nrC4yYCMrEwcYBGxTsOtMXdrXpQwzDLjVuu55MKFyCg/GoCRGiex6ePHnS6Df4AfVAK87LEHGZOLjbgU7LTXbAe0Q0zESdbVjASOyIk0fB9DFQDGLkfWiZjwH4yN0khinYNWILIyWilYLZvINLVhVmjGZ63M+fP2+YCZ0CxbJ0lNx2JxEFGMwN6gb7RAP5sdm/i4UiZiIpAwfZshmowYkIym6aiNk1pOqA2VBsYkoGDPm6BtNFQxGzfLKMel6MgYjobvAzo7e54NatW414B9M3CGPUVgGedAP6Vz9yX79+vdM32eVklxIaMdOnFyJ2Ekfab9++dbvP1MJqA/3cvHmz9cWX6MUJcisWK86XL182dEGxjb6AdxMK+gn0qc8xIfQi74LpY6AYxPT7cHALDDDEED9+/Gi2s8rw5OTEo+BAMWAlYZJgCzWGYqVwoE2tZg3AQDGIAcg7lKRmlcRXVih2sxBjHErbqh3LMUDEpL+Jioiwata/HE/H7lsMYkcUQAHo4NKOivtfxZAbO31L9EAUUYPFHH30J30R3Dxk9RsdzOpY+4lBzEiE5GQ8MaDtzfupybRKHUIP02rprLbFIGZ42PqvA0Vg6wWtUUBENIej7EIhZ14ji4NNYuCkB1qngTYYrJNuF2kop/U3HYIT0rso8xDKGEIPU2x/MYgp9lrVuTBQGNgxBo6zuGIQx9nv1erCQGGgMLASA8UgVqKoIhQGCgOFgePEQDGI4+z3Q2t1tacwUBjYAgaKQWwBqZVlYaAwUBg4BAwUgziEXqw2FAYKA4WBLWBgJwxiC/WuLAsDhYHCQGFgyxgoBrFlBFf2hYHCQGFgqhgoBrHHnnP7l7uBExhNY3Av3Z4sdTKl7B18+PChsZ7KcB6jefwAa5/MbntPkBdroF++fGnp554GBtyY5U4/J2rFE5Z+0vBzaUz6ebLbpCzvQB3UhU0fbsByKCNvzDlwJzD0B9LtKY640nADeclT3txAmcr2nqBu6qiu6acN/LQp/bRVm4WlnzTiwVH6eV6E702Sya7aO4S+0Bhae/fuXUc7aBBu4CgB7tBsuj2VCddwzg30Bdrs9/Hp6WljWFIfipPAT1i6pWFSHE30/eBQWennqS7L6EvdhQNt0rYh9LVJWhh7XsUg9thDEdFd4hMxe2ZVImbuiEivf+JFzPwj4sw/I0Zc7hcRXdSIOEsbsfxdxIh/w/iBiLk/N4jYrV9EKHZlOyKWx+sS//mJiLM8/ji7/4i5X0R0fpv8iYhLy8yyIubxIqLzjoiztBHL30WM+DeMH4iY+3ODiLlfxPl3cUDEPIwbRMz9IoLXufrxjIgzf24QMfeLCF4dRMSlcUWKmMeJCF4dRMSlaSNi7XgRs7RdBkfwUwxij53MBs6zZ8/as7/Anr87HdLtyfaLC1u8A3dEu+uZtVU2/PkBtvrZUPKeIC93NjC+l34PHjxo7oa4d+/eWbl37txpzIAIy3jSSHv37t2zeMKYGlCWd6AO6tJvy6NHj5rrLN0PIE7CtWvX2rU/kG5PccSVhhvIS57y5gbKVLb3BHVTR3VNP23QFm1KP23VZmHpJ420cJR+nhfhe5Nksqv2wqM2Jfwf+kJjaC3TokG4Sbcn3MnTe4Iy4RrO009foM1+H9++fbuxAaYPM54nP2HegTRuOpQvN+AHh30//uqyjL7UXTjQJm0bQl+bpIWx5/UfAAAA//+ylo5QAAAABklEQVQDANcjxZfvDDcbAAAAAElFTkSuQmCC\" width=\"392\" height=\"486\"\u003e\u003c/p\u003e\n\u003cp\u003eThirty ICU sepsis patients were enrolled and randomized equally into the probiotic group (n=15) and placebo group (n=15). Both groups were comparable in demographic and clinical characteristics at baseline, enabling a valid assessment of the intervention\u0026rsquo;s effects.\u003c/p\u003e\n\u003ctable border=\"1\" cellspacing=\"0\" cellpadding=\"0\" width=\"474\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 134px;\"\u003e\n \u003cp\u003e\u003cstrong\u003eKarakteristik\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 90px;\"\u003e\n \u003cp\u003e\u003cstrong\u003eKelompok Probiotik\u003c/strong\u003e\u003c/p\u003e\n \u003cp\u003e\u003cstrong\u003e(n = 15)\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 97px;\"\u003e\n \u003cp\u003e\u003cstrong\u003eKontrol\u003c/strong\u003e\u003c/p\u003e\n \u003cp\u003e\u003cstrong\u003e(n = 15)\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 57px;\"\u003e\n \u003cp\u003e\u003cstrong\u003ep \u003cem\u003evalue\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 96px;\"\u003e\n \u003cp\u003e\u003cstrong\u003eTotal\u003c/strong\u003e\u003c/p\u003e\n \u003cp\u003e\u003cstrong\u003e(n = 30)\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 134px;\"\u003e\n \u003cp\u003eAge (year)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 90px;\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 97px;\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 57px;\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 96px;\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 134px;\"\u003e\n \u003cp\u003eMean\u0026plusmn;SD\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 90px;\"\u003e\n \u003cp\u003e48,67\u0026plusmn;12,1\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 97px;\"\u003e\n \u003cp\u003e45,46\u0026plusmn;11,28\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 57px;\"\u003e\n \u003cp\u003e0,461\u003csup\u003e#\u003c/sup\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 96px;\"\u003e\n \u003cp\u003e47,06\u0026plusmn;11,64\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 134px;\"\u003e\n \u003cp\u003eGender (n[%])\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 90px;\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 97px;\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 57px;\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 96px;\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 134px;\"\u003e\n \u003cp\u003eMale\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 90px;\"\u003e\n \u003cp\u003e11 (73,3%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 97px;\"\u003e\n \u003cp\u003e6 (40%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width: 57px;\"\u003e\n \u003cp\u003e0,065*\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 96px;\"\u003e\n \u003cp\u003e17 (56,7%)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 134px;\"\u003e\n \u003cp\u003eFemale\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 90px;\"\u003e\n \u003cp\u003e4 (26,7%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 97px;\"\u003e\n \u003cp\u003e9 (60%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 96px;\"\u003e\n \u003cp\u003e13 (43,3%)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 134px;\"\u003e\n \u003cp\u003eWeight (kg)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 90px;\"\u003e\n \u003cp\u003e61,18\u0026plusmn;8,69\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 97px;\"\u003e\n \u003cp\u003e55,98\u0026plusmn;8,79\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 57px;\"\u003e\n \u003cp\u003e0,115\u003csup\u003e#\u003c/sup\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 96px;\"\u003e\n \u003cp\u003e58,58\u0026plusmn;8,99\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 134px;\"\u003e\n \u003cp\u003eHeight (cm)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 90px;\"\u003e\n \u003cp\u003e166\u0026plusmn;7,57\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 97px;\"\u003e\n \u003cp\u003e161,93\u0026plusmn;7,75\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 57px;\"\u003e\n \u003cp\u003e0,157\u003csup\u003e#\u003c/sup\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 96px;\"\u003e\n \u003cp\u003e163,96\u0026plusmn;7,8\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 134px;\"\u003e\n \u003cp\u003eBMI (kg/m\u003csup\u003e2\u003c/sup\u003e)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 90px;\"\u003e\n \u003cp\u003e22,05\u0026plusmn;1,35\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 97px;\"\u003e\n \u003cp\u003e21,18\u0026plusmn;1,45\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 57px;\"\u003e\n \u003cp\u003e0,101\u003csup\u003e#\u003c/sup\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 96px;\"\u003e\n \u003cp\u003e21,62\u0026plusmn;1,45\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 134px;\"\u003e\n \u003cp\u003eAlbumin (gr/dL)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 90px;\"\u003e\n \u003cp\u003e3,04\u0026plusmn;0,22\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 97px;\"\u003e\n \u003cp\u003e3,0\u0026plusmn;0,42\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 57px;\"\u003e\n \u003cp\u003e0,77\u003csup\u003e#\u003c/sup\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 96px;\"\u003e\n \u003cp\u003e3,02\u0026plusmn;0,33\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 134px;\"\u003e\n \u003cp\u003eSOFA Score\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 90px;\"\u003e\n \u003cp\u003e5,4\u0026plusmn;1,88\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 97px;\"\u003e\n \u003cp\u003e5,33\u0026plusmn;1,54\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 57px;\"\u003e\n \u003cp\u003e0,272\u003csup\u003e#\u003c/sup\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 96px;\"\u003e\n \u003cp\u003e5,37\u0026plusmn;1,69\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 134px;\"\u003e\n \u003cp\u003eDiagnosis (n[%])\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 90px;\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 97px;\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 57px;\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 96px;\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 134px;\"\u003e\n \u003cp\u003eRespiratory\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 90px;\"\u003e\n \u003cp\u003e10 (66,7%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 97px;\"\u003e\n \u003cp\u003e7 (46,7%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"5\" style=\"width: 57px;\"\u003e\n \u003cp\u003e0,749*\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 96px;\"\u003e\n \u003cp\u003e17 (56,7%)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 134px;\"\u003e\n \u003cp\u003eUrogenital\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 90px;\"\u003e\n \u003cp\u003e2 (13,3%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 97px;\"\u003e\n \u003cp\u003e3 (20%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 96px;\"\u003e\n \u003cp\u003e5 (16,7%)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 134px;\"\u003e\n \u003cp\u003eSSTI\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 90px;\"\u003e\n \u003cp\u003e2 (13,3%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 97px;\"\u003e\n \u003cp\u003e3 (20%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 96px;\"\u003e\n \u003cp\u003e5 (16,7%)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 134px;\"\u003e\n \u003cp\u003eMusculoskeletal\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 90px;\"\u003e\n \u003cp\u003e1 (6,7%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 97px;\"\u003e\n \u003cp\u003e1 (6,7%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 96px;\"\u003e\n \u003cp\u003e2 (6,7%)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 134px;\"\u003e\n \u003cp\u003eNervous system\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 90px;\"\u003e\n \u003cp\u003e0 (0%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 97px;\"\u003e\n \u003cp\u003e1 (6,7%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 96px;\"\u003e\n \u003cp\u003e1 (3,3%)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 134px;\"\u003e\n \u003cp\u003eMechanical Ventilation\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 90px;\"\u003e\n \u003cp\u003e15 (100%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 97px;\"\u003e\n \u003cp\u003e15 (100%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 57px;\"\u003e\n \u003cp\u003e1,00*\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 96px;\"\u003e\n \u003cp\u003e30 (100%)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp\u003e*Uji \u003cem\u003eChi Square\u003c/em\u003e; \u003csup\u003e#\u003c/sup\u003eUji T Independen\u003c/p\u003e\n\u003cp\u003eIn the probiotic group, median PCT levels declined from 3.39 ng/mL to 1.13 ng/mL, CRP from 0.7 mg/L to 0.5 mg/L, and IL-6 from 79.47 pg/mL to 77.92 pg/mL. Though not statistically significant, the decrease in PCT approached significance (p = 0.061), suggesting a potential biological effect.\u003c/p\u003e\n\u003ctable border=\"1\" cellspacing=\"0\" cellpadding=\"0\" width=\"397\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"2\" style=\"width: 66px;\"\u003e\n \u003cp\u003e\u003cstrong\u003eVariabel\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 267px;\"\u003e\n \u003cp\u003e\u003cstrong\u003ePeriode Pemeriksaan (Median[Min-Max])\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width: 63px;\"\u003e\n \u003cp\u003e\u003cstrong\u003ep \u003cem\u003evalue\u003c/em\u003e*\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 137px;\"\u003e\n \u003cp\u003e\u003cstrong\u003eT0\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 130px;\"\u003e\n \u003cp\u003e\u003cstrong\u003eT1\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 66px;\"\u003e\n \u003cp\u003eIL-6\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 137px;\"\u003e\n \u003cp\u003e79,47 (8,66 \u0026ndash; 333,23)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 130px;\"\u003e\n \u003cp\u003e77,92 (17,97 \u0026ndash; 288,8)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63px;\"\u003e\n \u003cp\u003e0,91\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 66px;\"\u003e\n \u003cp\u003ePCT\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 137px;\"\u003e\n \u003cp\u003e3,39 (0,22 \u0026ndash; 160,4)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 130px;\"\u003e\n \u003cp\u003e1,13 (0,16 \u0026ndash; 128,4)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63px;\"\u003e\n \u003cp\u003e0,061\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 66px;\"\u003e\n \u003cp\u003eCRP\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 137px;\"\u003e\n \u003cp\u003e0,7 (0,5 \u0026ndash; 14,2)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 130px;\"\u003e\n \u003cp\u003e0,5 (0,5 \u0026ndash; 10,8)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63px;\"\u003e\n \u003cp\u003e0,261\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp\u003e*Uji \u003cem\u003eWilcoxon\u003c/em\u003e\u003c/p\u003e\n\u003cp\u003eIn contrast, the placebo group showed clinical increases in IL-6 (from 97.53 to 146.9 pg/mL), PCT (1.32 to 2.5 ng/mL), and CRP (0.7 to 1.4 mg/L), none of which reached statistical significance. Between-group comparisons on day 4 revealed lower biomarker levels in the probiotic group, with p-values of 0.084 (IL-6), 0.174 (PCT), and 0.250 (CRP), indicating a non-significant but favorable trend.\u003c/p\u003e\n\u003ctable border=\"1\" cellspacing=\"0\" cellpadding=\"0\" width=\"416\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"2\" style=\"width: 66px;\"\u003e\n \u003cp\u003e\u003cstrong\u003eVariabel\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 283px;\"\u003e\n \u003cp\u003e\u003cstrong\u003ePeriode (Median [Min-Max])\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width: 66px;\"\u003e\n \u003cp\u003e\u003cstrong\u003ep \u003cem\u003evalue\u003c/em\u003e*\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 142px;\"\u003e\n \u003cp\u003e\u003cstrong\u003eT0\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 142px;\"\u003e\n \u003cp\u003e\u003cstrong\u003eT1\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 66px;\"\u003e\n \u003cp\u003eIL-6\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 142px;\"\u003e\n \u003cp\u003e97,53 (22,06 \u0026ndash; 300,36)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 142px;\"\u003e\n \u003cp\u003e146,9 (34,47 \u0026ndash; 338,31)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 66px;\"\u003e\n \u003cp\u003e0,156\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 66px;\"\u003e\n \u003cp\u003ePCT\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 142px;\"\u003e\n \u003cp\u003e1,32 (0,09 \u0026ndash; 108,5)\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 142px;\"\u003e\n \u003cp\u003e2,5 (0,72 - 106)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 66px;\"\u003e\n \u003cp\u003e0,155\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 66px;\"\u003e\n \u003cp\u003eCRP\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 142px;\"\u003e\n \u003cp\u003e0,7 (0,5 \u0026ndash; 3,02)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 142px;\"\u003e\n \u003cp\u003e1,4 (0,5 \u0026ndash; 39,2)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 66px;\"\u003e\n \u003cp\u003e0,062\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp\u003e*Uji \u003cem\u003eWilcoxon\u003c/em\u003e\u003c/p\u003e\n\u003cp\u003eSignificant improvements were observed in the probiotic group\u0026rsquo;s gastrointestinal outcomes. By days 3 and 4, defecation frequency and stool consistency had normalized in most probiotic patients, showing a statistically significant difference compared to controls (p \u0026lt; 0.05).\u0026nbsp;\u003c/p\u003e\n\u003ctable border=\"1\" cellspacing=\"0\" cellpadding=\"0\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"2\" style=\"width: 66px;\"\u003e\n \u003cp\u003e\u003cstrong\u003eVariabel\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 133px;\"\u003e\n \u003cp\u003e\u003cstrong\u003eProbiotic Group\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 122px;\"\u003e\n \u003cp\u003e\u003cstrong\u003eControl Group\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width: 66px;\"\u003e\n \u003cp\u003e\u003cstrong\u003ep \u003cem\u003evalue\u003c/em\u003e*\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" rowspan=\"2\" style=\"width: 113px;\"\u003e\n \u003cp\u003e\u003cstrong\u003eRR (95% CI)\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 75px;\"\u003e\n \u003cp\u003e\u003cstrong\u003en\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58px;\"\u003e\n \u003cp\u003e\u003cstrong\u003e%\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58px;\"\u003e\n \u003cp\u003e\u003cstrong\u003en\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 64px;\"\u003e\n \u003cp\u003e\u003cstrong\u003e%\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 66px;\"\u003e\n \u003cp\u003eH1\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 75px;\"\u003e\n \u003cp\u003e7\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58px;\"\u003e\n \u003cp\u003e46,7\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58px;\"\u003e\n \u003cp\u003e7\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 64px;\"\u003e\n \u003cp\u003e46,7\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 66px;\"\u003e\n \u003cp\u003e1,00\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 113px;\"\u003e\n \u003cp\u003e1,00 (0,51 \u0026ndash; 1,95)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 66px;\"\u003e\n \u003cp\u003eH2\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 75px;\"\u003e\n \u003cp\u003e8\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58px;\"\u003e\n \u003cp\u003e53,3\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58px;\"\u003e\n \u003cp\u003e5\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 64px;\"\u003e\n \u003cp\u003e33,3\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 66px;\"\u003e\n \u003cp\u003e0,27\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 113px;\"\u003e\n \u003cp\u003e0,7 (0,37 \u0026ndash; 1,34)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 66px;\"\u003e\n \u003cp\u003eH3\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 75px;\"\u003e\n \u003cp\u003e13\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58px;\"\u003e\n \u003cp\u003e86,7\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58px;\"\u003e\n \u003cp\u003e5\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 64px;\"\u003e\n \u003cp\u003e33,3\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 66px;\"\u003e\n \u003cp\u003e0,03\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 113px;\"\u003e\n \u003cp\u003e0,2 (0,05 \u0026ndash; 0,76)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 66px;\"\u003e\n \u003cp\u003eH4\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 75px;\"\u003e\n \u003cp\u003e14\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58px;\"\u003e\n \u003cp\u003e93,3\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58px;\"\u003e\n \u003cp\u003e7\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 64px;\"\u003e\n \u003cp\u003e46,7\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 66px;\"\u003e\n \u003cp\u003e0,04\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 113px;\"\u003e\n \u003cp\u003e0,12 (0,02 \u0026ndash; 0,88)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"7\" style=\"width: 488px;\"\u003e\n \u003cp\u003e*Uji \u003cem\u003eChi Square\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 13px;\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003ctable border=\"1\" cellspacing=\"0\" cellpadding=\"0\" width=\"548\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"2\" style=\"width: 85px;\"\u003e\n \u003cp\u003e\u003cstrong\u003eTime\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width: 86px;\"\u003e\n \u003cp\u003e\u003cstrong\u003eIntervention\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width: 240px;\"\u003e\n \u003cp\u003e\u003cstrong\u003eDefecacy Consistension (n[%])\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width: 73px;\"\u003e\n \u003cp\u003e\u003cstrong\u003eTotal\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width: 65px;\"\u003e\n \u003cp\u003e\u003cstrong\u003ep v\u003cem\u003ealue\u003c/em\u003e*\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 82px;\"\u003e\n \u003cp\u003e\u003cstrong\u003eHard\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 75px;\"\u003e\n \u003cp\u003e\u003cstrong\u003eNormal\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 83px;\"\u003e\n \u003cp\u003e\u003cstrong\u003eSoft\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"2\" style=\"width: 85px;\"\u003e\n \u003cp\u003eH1\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 86px;\"\u003e\n \u003cp\u003eProbiotik\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 82px;\"\u003e\n \u003cp\u003e3 (42,86%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 75px;\"\u003e\n \u003cp\u003e3 (42,86%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 83px;\"\u003e\n \u003cp\u003e1 (14,28%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 73px;\"\u003e\n \u003cp\u003e7\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width: 65px;\"\u003e\n \u003cp\u003e0,751\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 86px;\"\u003e\n \u003cp\u003eKontrol\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 82px;\"\u003e\n \u003cp\u003e2 (28,57%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 75px;\"\u003e\n \u003cp\u003e2 (28,57%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 83px;\"\u003e\n \u003cp\u003e3 (42,86%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 73px;\"\u003e\n \u003cp\u003e7\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"2\" style=\"width: 85px;\"\u003e\n \u003cp\u003eH2\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 86px;\"\u003e\n \u003cp\u003eProbiotik\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 82px;\"\u003e\n \u003cp\u003e1 (12,5%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 75px;\"\u003e\n \u003cp\u003e6 (75%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 83px;\"\u003e\n \u003cp\u003e1 (12,5%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 73px;\"\u003e\n \u003cp\u003e8\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width: 65px;\"\u003e\n \u003cp\u003e0,223\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 86px;\"\u003e\n \u003cp\u003eKontrol\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 82px;\"\u003e\n \u003cp\u003e0\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 75px;\"\u003e\n \u003cp\u003e4 (80%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 83px;\"\u003e\n \u003cp\u003e1 (20%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 73px;\"\u003e\n \u003cp\u003e5\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"2\" style=\"width: 85px;\"\u003e\n \u003cp\u003eH3\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 86px;\"\u003e\n \u003cp\u003eProbiotik\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 82px;\"\u003e\n \u003cp\u003e0\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 75px;\"\u003e\n \u003cp\u003e13 (100)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 83px;\"\u003e\n \u003cp\u003e0\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 73px;\"\u003e\n \u003cp\u003e13\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width: 65px;\"\u003e\n \u003cp\u003e0,001\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 86px;\"\u003e\n \u003cp\u003eKontrol\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 82px;\"\u003e\n \u003cp\u003e1 (20%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 75px;\"\u003e\n \u003cp\u003e1 (20%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 83px;\"\u003e\n \u003cp\u003e3 (60%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 73px;\"\u003e\n \u003cp\u003e5\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"2\" style=\"width: 85px;\"\u003e\n \u003cp\u003eH4\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 86px;\"\u003e\n \u003cp\u003eProbiotik\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 82px;\"\u003e\n \u003cp\u003e0\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 75px;\"\u003e\n \u003cp\u003e14 (100%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 83px;\"\u003e\n \u003cp\u003e0\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 73px;\"\u003e\n \u003cp\u003e14\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width: 65px;\"\u003e\n \u003cp\u003e0,014\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 86px;\"\u003e\n \u003cp\u003eKontrol\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 82px;\"\u003e\n \u003cp\u003e2 (28,57%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 75px;\"\u003e\n \u003cp\u003e3 (42,86%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 83px;\"\u003e\n \u003cp\u003e2 (28,57%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 73px;\"\u003e\n \u003cp\u003e7\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"7\" style=\"width: 548px;\"\u003e\n \u003cp\u003e*Uji \u003cem\u003eMann-Whitney\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp\u003eThis suggests beneficial modulation of gut microbiota, often impaired in sepsis patients due to critical illness and antibiotic use.\u003c/p\u003e"},{"header":"Discussion","content":"\u003cp\u003eThis study aimed to evaluate the effect of administering the probiotic \u003cem\u003eLactiplantibacillus plantarum\u003c/em\u003e DAD-13 on inflammatory biomarkers\u0026mdash;namely IL-6, CRP, and PCT\u0026mdash;in sepsis patients admitted to the intensive care unit. Although no statistically significant differences were found, the results demonstrated a downward trend in inflammatory biomarkers in the probiotic group compared to the placebo group. The most notable decrease occurred in PCT levels, with a p-value of 0.061, indicating potential clinical significance despite not reaching conventional statistical thresholds.\u003c/p\u003e\u003cp\u003ePCT is a specific biomarker for systemic infection and is widely used for diagnosing and evaluating therapeutic response in sepsis. The sharper decline in PCT levels in the probiotic group suggests a potential improvement in systemic inflammatory response due to the immunomodulatory effects of the probiotic. This aligns with findings from Miri et al. (\u003cspan citationid=\"CR7\" class=\"CitationRef\"\u003e2022\u003c/span\u003e), which showed that \u003cem\u003eL. plantarum\u003c/em\u003e administration suppressed proinflammatory cytokines, including IL-6 and TNF-α, by inhibiting the TLR4/NF-κB pathway. The concurrent reductions in IL-6 and CRP levels observed in this study further support the hypothesis that probiotics act through modulation of the innate immune system.\u003c/p\u003e\u003cp\u003eThis effect may be reinforced by the fact that \u003cem\u003eL. plantarum\u003c/em\u003e DAD-13 is a locally derived strain that has demonstrated strong resilience in the gastrointestinal tract, along with antibacterial and anti-inflammatory properties. Several preclinical studies have shown that this strain enhances IgA production, reduces pathogenic colonization (such as \u003cem\u003eEscherichia coli\u003c/em\u003e), and improves the condition of intestinal mucosa (Darmastuti et al., \u003cspan citationid=\"CR2\" class=\"CitationRef\"\u003e2021\u003c/span\u003e; Nurliyani et al., \u003cspan citationid=\"CR8\" class=\"CitationRef\"\u003e2022\u003c/span\u003e). These findings suggest that \u003cem\u003eL. plantarum\u003c/em\u003e DAD-13 not only modulates systemic immune responses but also restores gastrointestinal integrity disrupted by sepsis and intensive antibiotic therapy.\u003c/p\u003e\u003cp\u003eIntestinal microbiota imbalance (dysbiosis) is a key factor in the pathogenesis of sepsis through the gut-organ axis. In sepsis, increased mucosal permeability facilitates endotoxin and microbial translocation into systemic circulation, exacerbating inflammation and leading to multiorgan dysfunction. Probiotics help restore intestinal eubiosis and prevent further barrier damage, thereby reducing systemic inflammatory stimuli (Fay et al., \u003cspan citationid=\"CR3\" class=\"CitationRef\"\u003e2019\u003c/span\u003e).\u003c/p\u003e\u003cp\u003eThis study also noted improvements in defecation frequency and quality in the probiotic group, which can serve as indirect indicators of gastrointestinal function recovery. This is significant because gut function is often overlooked in sepsis management, despite its central role in numerous immunological and metabolic pathways. The probiotic\u0026rsquo;s role in improving gut function reinforces its potential as a complementary therapy in an integrative approach to sepsis.\u003c/p\u003e\u003cp\u003eNonetheless, several limitations must be considered. The short intervention duration (4 days), small sample size, and concurrent treatments such as broad-spectrum antibiotics and opioids\u0026mdash;which may affect gut microbiota\u0026mdash;are factors that could influence the observed effects and limit the detection of statistically significant differences. Further research with larger sample sizes, extended intervention periods, and better control of confounding variables is needed to validate these findings and explore the underlying molecular mechanisms.\u003c/p\u003e\u003cp\u003eConsidering all these findings, \u003cem\u003eL. plantarum\u003c/em\u003e DAD-13 may be considered a supportive intervention in sepsis management, particularly in helping regulate systemic inflammation and maintain gastrointestinal function in ICU patients. This study provides an important early contribution to the development of locally sourced, microbiome-based therapies that are safe and potentially beneficial for critically ill patients.\u003c/p\u003e"},{"header":"Conclusion","content":"\u003cp\u003eAdministering \u003cem\u003eLactiplantibacillus plantarum\u003c/em\u003e DAD-13 to ICU sepsis patients resulted in decreased levels of IL-6, PCT, and CRP, with notable clinical improvement in gastrointestinal function. While statistical significance was not achieved, the trends suggest that \u003cem\u003eL. plantarum\u003c/em\u003e DAD-13 has potential as an adjunct immunomodulatory therapy for sepsis.\u003c/p\u003e\u003cp\u003eThese findings support the safety and tolerability of probiotic interventions in critical care and highlight the need for further studies exploring local probiotic strains in severe illness contexts.\u003c/p\u003e"},{"header":"Abbreviations","content":"\u003cp\u003eICU\u0026nbsp; \u0026nbsp; \u0026nbsp;: Intensive Care Unit\u003c/p\u003e\n\u003cp\u003ePCT\u0026nbsp; \u0026nbsp; \u0026nbsp;: Procalcitonin\u003c/p\u003e\n\u003cp\u003eIL-6\u0026nbsp; \u0026nbsp; \u0026nbsp;: Interleukin-6\u003c/p\u003e\n\u003cp\u003eCRP \u0026nbsp; \u0026nbsp; : C-Reactive Protein\u003c/p\u003e"},{"header":"Declarations","content":"\u003cp\u003e\u003cstrong\u003eETHICS APPROVAL AND CONSENT TO PARTICIPATE\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThis study was conducted in accordance with the ethical principles of the Declaration of Helsinki. Inform consent was obtained from all the participants.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eCONSENT FOR PUBLICATION\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eNot applicable.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAVAILABILITY OF DATA AND MATERIALS\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eData supporting the conclusions of this study are included in the article and its additional files.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eCOMPETING INTEREST\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eFUNDING\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe authors would like to thank PT Royal Medicalink Pharmalab for funding this study.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAUTHOR’S CONTRIBUTIONS\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eZ wrote the main manuscript\u003c/p\u003e\n\u003cp\u003eAH wrote the main manuscript\u003c/p\u003e\n\u003cp\u003eAPL wrote the main manuscript\u003c/p\u003e\n\u003cp\u003eYY wrote the main manuscript\u003c/p\u003e\n\u003cp\u003eAll authors reviewed the manuscript\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eACKNOWLEDGEMENTS\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe authors would like to thank PT Royal Medicalink Pharmalab for funding this study. The authors also would like to thank all the participants who participated in this study.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eREPORTING GUIDELINES\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThis manuscript adheres to the CONSORT 2010 checklist for reporting randomized controlled trials.\u003c/p\u003e"},{"header":"References","content":"\u003col\u003e\n\u003cli\u003eDang, A. T., \u0026amp; Marsland, B. J. (2019). Microbes, metabolites, and the gut\u0026ndash;lung axis. \u003cem\u003eMucosal Immunology\u003c/em\u003e, 12(4), 843\u0026ndash;850.\u003c/li\u003e\n\u003cli\u003eDarmastuti, N., et al. (2021). Efektivitas Lactiplantibacillus plantarum DAD-13 dalam menurunkan jumlah koloni \u003cem\u003eEscherichia coli\u003c/em\u003e di kolon pada tikus. \u003cem\u003eLaporan Penelitian\u003c/em\u003e, Universitas Gadjah Mada.\u003c/li\u003e\n\u003cli\u003eFay, K. T., Ford, M. L., Coopersmith, C. M. (2019). The intestinal microenvironment in sepsis. \u003cem\u003eBiochimica et Biophysica Acta (BBA) - Molecular Basis of Disease\u003c/em\u003e, 1865(5), 1129\u0026ndash;1135.\u003c/li\u003e\n\u003cli\u003eGong, J., et al. (2019). Effects of probiotics on liver injury induced by sepsis in murine models. \u003cem\u003eJournal of Hepatology Research\u003c/em\u003e, 4(2), 34\u0026ndash;42.\u003c/li\u003e\n\u003cli\u003eKim, S. K., et al. (2017). Immunomodulatory effects of \u003cem\u003eLactobacillus plantarum\u003c/em\u003e lysates on lipopolysaccharide-stimulated macrophages via MAPK and NF-\u0026kappa;B signaling pathways. \u003cem\u003eNutrition Research and Practice\u003c/em\u003e, 11(2), 97\u0026ndash;104.\u003c/li\u003e\n\u003cli\u003eLi, Y., et al. (2016). The epidemiology of sepsis in intensive care units in Asia. \u003cem\u003eCritical Care Medicine\u003c/em\u003e, 44(8), e377\u0026ndash;e386.\u003c/li\u003e\n\u003cli\u003eMiri, H., et al. (2022). Lactobacillus plantarum from fermented soy suppresses inflammation in septic rats. \u003cem\u003eNutrition Research\u003c/em\u003e, 102, 35\u0026ndash;45.\u003c/li\u003e\n\u003cli\u003eNurliyani, N., et al. (2022). Kombinasi probiotik \u003cem\u003eL. plantarum\u003c/em\u003e DAD-13 dan serat ubi jalar meningkatkan kadar IgA di saluran cerna tikus. \u003cem\u003eJurnal Ilmu Ternak\u003c/em\u003e, 22(1), 34\u0026ndash;42.\u003c/li\u003e\n\u003cli\u003eTsilika, M., et al. (2021). Early administration of probiotics in ICU patients reduces incidence of ventilator-associated pneumonia and sepsis. \u003cem\u003eClinical Nutrition\u003c/em\u003e, 40(2), 507\u0026ndash;515.\u003c/li\u003e\n\u003cli\u003eWischmeyer, P. E., et al. (2016). Role of the microbiome, probiotics, and \u0026lsquo;dysbiosis therapy\u0026rsquo; in critical illness. \u003cem\u003eCurrent Opinion in Critical Care\u003c/em\u003e, 22(4), 347\u0026ndash;353.\u003c/li\u003e\n\u003c/ol\u003e"}],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":true,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":false,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":false,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"sepsis, probiotics, Lactiplantibacillus plantarum DAD-13, inflammatory markers, ICU","lastPublishedDoi":"10.21203/rs.3.rs-7174498/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-7174498/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003eSepsis remains a major global health issue with high morbidity and mortality rates, particularly in intensive care units (ICU). This study investigated the effects of administering the probiotic \u003cem\u003eLactiplantibacillus plantarum\u003c/em\u003e Dad-13 on inflammatory markers (procalcitonin [PCT], C-reactive protein [CRP], interleukin-6 [IL-6]) and defecation profiles in sepsis patients admitted to the ICU at RSUP H. Adam Malik Medan. A randomized, double-blind, placebo-controlled clinical trial was conducted with 30 sepsis patients divided into two groups: one receiving \u003cem\u003eL. plantarum\u003c/em\u003e Dad-13 (2 capsules/day for 4 days) and the other a placebo. Biomarker levels and defecation frequency/consistency were monitored.Trial registration: ClinicalTrials.gov Identifier: NCT07072871, registered on 21 July 2025. Retrospectively registered.\u003c/p\u003e\n\u003cp\u003eResults showed a clinical reduction in PCT, CRP, and IL-6 levels in the probiotic group compared to the placebo group, though the changes were not statistically significant (p \u0026gt; 0.05). Defecation frequency and stool consistency improved significantly in the probiotic group by days 3 and 4 (p \u0026lt; 0.05), indicating enhanced gut microbiota balance. The study suggests that \u003cem\u003eL. plantarum\u003c/em\u003e Dad-13 may aid in modulating inflammatory responses and improving gastrointestinal function in sepsis patients, albeit further research with longer intervention periods and larger samples is needed to confirm these findings.\u003c/p\u003e","manuscriptTitle":"The Effect of Administering the Probiotic Lactiplantibacillus Plantarum DAD-13 on Procalcitonin Levels, C-Reactive Protein, and Interleukin-6 in Sepsis Patients in the Intensive Care Unit of H. Adam Malik Hospital, Medan","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2025-10-09 15:20:23","doi":"10.21203/rs.3.rs-7174498/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"aabedcf8-dfb2-4eef-b17a-2dd7c1f2c48c","owner":[],"postedDate":"October 9th, 2025","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[],"tags":[],"updatedAt":"2026-02-10T07:55:50+00:00","versionOfRecord":[],"versionCreatedAt":"2025-10-09 15:20:23","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-7174498","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-7174498","identity":"rs-7174498","version":["v1"]},"buildId":"8U1c8b4HqxoKbykW_rLl7","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}