The prognostic value of VISTA combined with imaging in pancreatic cancer patients

The prognostic value of VISTA combined with imaging in pancreatic cancer patients | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article The prognostic value of VISTA combined with imaging in pancreatic cancer patients Lubing Zhu, Kaiwei Xu, Shuai Fang, Linwei Wang, Chunqu Chen, Ruoyu Wu, and 4 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-3855646/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Pancreatic ductal carcinoma (PDAC) is a malignant tumor of the digestive tract characterized by a gradual onset, rapid progression and poor prognosis. VISTA is a newly discovered immune checkpoint belonging to the B7 family of PD-1 and PD-L1. In this study, VISTA expression in tumor tissues was significantly higher than that in para-cancer tissues. It may also be associated with PDAC’s tumor immunosuppressive microenvironment. Furthermore, the best prognosis involved pancreatic cancer patients with high VISTA expression alongside a more uniform CT density. In addition, through immunohistochemistry, CCK-8 and EDU experiments, it was found that PTBP1 improved the immune infiltration of PDAC by regulating the expression of VISTA and promoting the expression of IFN-γ, TNF-α and other cytokines that delay the progression of tumors. Pancreatic ductal carcinoma (PDAC) Medical image VISTA Tumor immunity Full Text Additional Declarations No competing interests reported. Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-3855646","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":267046585,"identity":"da6f09f6-b25e-4c34-973f-c5c1634459a0","order_by":0,"name":"Lubing Zhu","email":"","orcid":"","institution":"Ningbo University","correspondingAuthor":false,"prefix":"","firstName":"Lubing","middleName":"","lastName":"Zhu","suffix":""},{"id":267046586,"identity":"4bd358a0-c7c0-4c3e-93ba-5954a87bd837","order_by":1,"name":"Kaiwei Xu","email":"","orcid":"","institution":"Ningbo 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VISTA is a newly discovered immune checkpoint belonging to the B7 family of PD-1 and PD-L1. In this study, VISTA expression in tumor tissues was significantly higher than that in para-cancer tissues. It may also be associated with PDAC\u0026rsquo;s tumor immunosuppressive microenvironment. Furthermore, the best prognosis involved pancreatic cancer patients with high VISTA expression alongside a more uniform CT density. 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