The clinical experience for optimizing the reparative processes of the cervix after destructive surgical interventions

The objective: to evaluate the therapeutic approach in order to improve regenerate the epithelium of the cervical mucosa and restore of the vaginal biocenosis after laser vaporization in women of reproductive age with CIN I with including the vaginal gel which consist of decametoxinum and hyaluronic acid. Materials and methods. 60 women of reproductive age were examined with CIN І, confirmed by histological examination, which underwent laser vaporization. The main clinical group (n=30), for patients were prescribed 5 ml vaginal gel which consist of decametoxinum and hyaluronic acid (Ginodek®) for 7–10 days after laser vaporization with a course of 14 days. The comparison group were consisted of 30 patients who, after laser destruction of the cervix, were prescribed standard therapy. We were used colposcopy for visual inspection of the cervical reparative processes. According to the results of a microbiological study, the vaginal biocenosis was evaluated. The side effects that were associated with the use of Ginodek® vaginal gel were evaluated. Results. It was proved that the use of vaginal gel Ginodek® in patients with CIN I after laser vaporization resulted in faster and more complete epithelialization of the wound surface than the standard therapy (RR 1.56; 95% CI: 1.08–2.26; p=0.02). 2 months after the application of vaginal gel Ginodek®, we found significant increasing cases of normalization of vaginal microbiota (RR 1.44; 95% CI: 1.04–2.00; p=0.03), increase in the number of lactobacilli in the vaginal secretion (RR 1.50; 95% CI: 1.03–2.19; p=0.04) and a decrease in the number of cases of vaginal candidiasis (RR 1.27; 95% CI: 1.005–1.61; p=0.045). Not a single adverse effects on were noted when using vaginal gel Ginodek®, both during the course of therapy and at a later date. Conclusion. The obtained results were testified to the acceleration of the reparative processes of the cervix, the reduction of the microbial effect and safety when using vaginal gel Ginodek® after laser vaporization in women with CIN І. Key words: cervical neoplasia, laser vaporization, vaginal microbiota, epithelization, Ginodek®.