Associations between circulating sex steroid hormones and leukocyte telomere length in men in the National Health and Nutrition Examination Survey

Sally B. Coburn, Barry I. Graubard, Britton Trabert, Katherine A. McGlynn, Michael B. Cook
In: Andrology · 2018 · vol. 6(4) , pp. 542–546 · doi:10.1111/andr.12494 · PMID:29752772 · W2799563601
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

Higher circulating estradiol levels were associated with shorter leukocyte telomere length in men, whereas testosterone and its metabolites showed no such association.

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Abstract

= -67, p = 0.03). Testosterone, free testosterone, androstanediol glucuronide, and SHBG were not associated with leukocyte telomere length. The inverse association seen in this study indicates that a danazol-induced hypoestrogenic state could partly underlie the previously observed association between danazol therapy and increased leukocyte telomere length.

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