Treating Dysmenorrhea with Anti‐inflammatory Agents: A Double‐Blind Trial With Naproxen Sodium
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A double-blind trial found that naproxen sodium significantly reduced menstrual pain in dysmenorrheic patients compared to placebo over three cycles.
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Abstract
ABSTRACT Thirty‐two dysmenorrheic patients participated in a double‐blind trial of naproxen sodium for three consecutive menstrual cycles. The women were divided into two groups: 15 women were given naproxen sodium (the sodium salt of d‐2‐(6‐methoxy‐2‐naphthyl) propionic acid) and 17 women received placebo tablets. The women were prescribed two tablets (550 mg) at the first sign of menstrual pain and one tablet (275 mg) thereafter every six hours, as required. There were no significant differences between the two groups in physical characteristics, obstetric and gynecologic histories, including the character of dysmenorrhea and pretreatment pain intensity scores (p = 0.7). Following intake of the drug or placebo, the participants rated the relief provided by the medication with a six‐point scoring system. When the scores for pain relief were tallied for the three treatment cycles, the naproxen sodium group averaged 13.7 ± 0.65 standard error, while the placebo group averaged 8.8 ± 0.95 standard error out of a possible maximum relief score of 18. The difference between the two groups was statistically significant at p = 0.0004. Few patients reported side effects.
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Cites (2)
- The effect of naproxen-sodium on the prostaglandin concentrations of the menstrual blood and uterine “jet-washings” in dysmenorrehic women 1978
- The Myometrial Response to Intra‐Uterine Administration of PGF<sub>2α</sub> and PGE<sub>2</sub> in Dysmenorrheic Women 1977
Cited by (3)
References (5)
- The effect of naproxen-sodium on the prostaglandin concentrations of the menstrual blood and uterine “jet-washings” in dysmenorrehic women via openalex
- The Myometrial Response to Intra‐Uterine Administration of PGF<sub>2α</sub> and PGE<sub>2</sub> in Dysmenorrheic Women via openalex
- W2037691565 via openalex
- W2119580505 via openalex
- W2405175138 via openalex
Cited by (3)
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- openalex
- last seen: 2026-06-10T17:14:06.276822+00:00
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