Effect of copper and platinum intrauterine devices on endometrial morphology and implantation in the rabbit

Jonathan A. Tobert, D. R. Davies
In: Reproduction · 1977 · vol. 50(1) , pp. 53–59 · doi:10.1530/jrf.0.0500053 · PMID:864653 · W2113331315
article OA: bronze CC0
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Abstract

The response of the rabbit endometrium to the copper IUD was investigated. A plastic IUD bearing copper foil (42 mm2) was inserted into one horn of the rabbit uterus and a physically similar platinum-bearing IUD in the contralateral horn served as a control. The Pt-IUD caused no tissue damage and little if any inflammatory reaction in ovariectomized, oestrous or pregnant animals, whereas the Cu-IUD produced endometrial ulcers in 14 out of 15 does in all hormonal states. The associated inflammation was particularly intense in the pregnant animals in which a unilateral pyometra was usually present. Despite the endometrial trauma produced, the Cu-IUD was only partly effective as a contraceptive agent, 36% of the ova shed from the ovary ipsilateral to the Cu-IUD implanting, compared with 63% of the ova ipsilateral to the Pt-IUD. However, almost half of the implantation swellings in the copper-bearing horns were abnormally small or distorted in shape at 9 days post coitum. The tissue destruction observed in the rabbit endometrium emphasizes the need for careful histological studies of the effect of the copper IUD on the human uterus.

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SciLite annotations

chemicals 7
copper platinum copper copper platinum copper copper
organisms 6
rabbits rabbits rabbits multicellular animals multicellular animals human

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