Effect of different drug therapy in central precocious puberty girls

Objective To analyse the effect induced by leuprorelin,danazlo,ketoconazole,medroxyprogesteron acetate in central precocious puberty (CPP) girls.Methods Sixty-one CPP girls were observed.Twenty-four patients were treated by leuprorelin [30-90 μg/(kg·m)],and comparable to danazol[12 patients,5-10 mg/(kg·d)],ketoconazole [12 patients,4-8 mg/(kg·d)] or medroxyprogesteron(13 patients, 8-10 mg/d). The sexual sign,bone age,serum hormone were compared before and during treatment.Results The second sexual sign descend and serum peak luteinizing hormone,follicle-stimulating hormone(FSH) and base FSH,insulin-like growth factor-1 declined during treatment by leuprorelin;although the second sexual sign descend in danazol groups,the serum maker was of no change and the serum alanine aminotransferase was step up in individual cases.Ketoconazole was not of obvious changes in sexual sign and serum hormone;medroxyprogesteron acetate can make breasts become smaller,but it also can lead to high bleeding rate of uterine.Conclusions Leuprorelin can make not only sexual sign change but also serum hormone and bone age decrease;but danazlo,ketoconazole and medroxy progesterm acetate are only effective to sexual sign and can't make other factors change.Otherwise there are of great side effects.Therefore leuprorelin is considered as a better drug of treating central precocious puberthy.