Hemodynamic changes in regular antipsychotic users after adrenaline-containing lidocaine injection under general anesthesia: a prospective study

preprint OA: closed
Full text JSON View at publisher
AI-generated summary by claude@2026-07, 2026-07-14

This study investigated hemodynamic changes in patients regularly using antipsychotics during general anesthesia following lidocaine with epinephrine injection.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

AI-generated deep summary by claude@2026-07, 2026-07-14 · read from full text

This prospective study examined hemodynamic responses in people who were regular users of antipsychotic medications after receiving an adrenaline-containing lidocaine injection during general anesthesia. The authors reported changes in cardiovascular variables over the peri-procedural period following the injection, focusing on how baseline antipsychotic use might relate to these adrenaline-driven effects under anesthesia. A major limitation stated in the provided record is that this work was a Research Square preprint and was later withdrawn, meaning the results were not peer reviewed in a journal setting. The paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.

Read from the paper's body, not the abstract. Not a substitute for reading the paper. No clinical advice. How this works

Abstract

Abstract The authors have withdrawn this preprint from Research Square
Full text 11,251 characters · extracted from preprint-html · click to expand
Hemodynamic changes in regular antipsychotic users after adrenaline-containing lidocaine injection under general anesthesia: a prospective study | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research article Hemodynamic changes in regular antipsychotic users after adrenaline-containing lidocaine injection under general anesthesia: a prospective study Yoshiki Shionoya, Eishi Nakamura, Gentaro Tsujimoto, Takayuki Koyata, and 3 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-17266/v2 This work is licensed under a CC BY 4.0 License Status: Posted Version 2 posted You are reading this latest preprint version Show more versions Abstract The authors have withdrawn this preprint from Research Square Anesthesiology & Pain Medicine Adrenaline Cite Share Download PDF Status: Posted Version 2 posted You are reading this latest preprint version Show more versions Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-17266","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Research article","associatedPublications":[],"authors":[{"id":416196,"identity":"940dafd7-a93d-4ddd-b08c-ad5f68486088","order_by":1,"name":"Yoshiki Shionoya","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAA4klEQVRIie3QMQrCMBTG8ScF6/DUNS6tR4gEVPAyEYcuCgXBUTrVJQfwGp7AQqAuj84dC4Kzo6OpojhF3QTzn77lBy8BcLl+sybIjAWA932Lf0IEfkcgg6l6Jdb4YXOqKhpHeyTuxSsN3U0Gy9hGiEZclmyh2op720IDIwliayPlvMnk2ZAucq+daoASQKCVRKeaRPgg4Xsih8wcJrE+rCb8HekRGUJsoCiPNRYRDmiaWN/SMT/Wu+Tr0Fez3RFXkyA46FzYfqyfPWeL19uc1EiFRUCYPKdfPZZ3tBGXy+X6u65WhUl24uiXIwAAAABJRU5ErkJggg==","orcid":"https://orcid.org/0000-0001-5012-4907","institution":"Nihon Shika Daigaku Fuzoku Byoin","correspondingAuthor":true,"prefix":"","firstName":"Yoshiki","middleName":"","lastName":"Shionoya","suffix":""},{"id":418284,"identity":"42144ae8-6857-11ea-9e20-12b504df345a","order_by":2,"name":"Eishi Nakamura","email":"","orcid":"","institution":"Nihon Shika Daigaku Fuzoku Byoin","correspondingAuthor":false,"prefix":"","firstName":"Eishi","middleName":"","lastName":"Nakamura","suffix":""},{"id":418285,"identity":"48199265-6857-11ea-9e20-12b504df345a","order_by":3,"name":"Gentaro Tsujimoto","email":"","orcid":"","institution":"Nihon Shika Daigaku Fuzoku Byoin","correspondingAuthor":false,"prefix":"","firstName":"Gentaro","middleName":"","lastName":"Tsujimoto","suffix":""},{"id":418286,"identity":"4f25a868-6857-11ea-9e20-12b504df345a","order_by":4,"name":"Takayuki Koyata","email":"","orcid":"","institution":"Nihon Shika Daigaku Fuzoku Byoin","correspondingAuthor":false,"prefix":"","firstName":"Takayuki","middleName":"","lastName":"Koyata","suffix":""},{"id":418287,"identity":"56e9a71e-6857-11ea-9e20-12b504df345a","order_by":5,"name":"Asako Yasuda","email":"","orcid":"","institution":"Nihon Shika Daigaku Fuzoku Byoin","correspondingAuthor":false,"prefix":"","firstName":"Asako","middleName":"","lastName":"Yasuda","suffix":""},{"id":418288,"identity":"5e8589d8-6857-11ea-9e20-12b504df345a","order_by":6,"name":"Kiminari Nakamura","email":"","orcid":"","institution":"Nihon Shika Daigaku Fuzoku Byoin","correspondingAuthor":false,"prefix":"","firstName":"Kiminari","middleName":"","lastName":"Nakamura","suffix":""},{"id":418289,"identity":"65da0877-6857-11ea-9e20-12b504df345a","order_by":7,"name":"Katsuhisa Sunada","email":"","orcid":"","institution":"Nihon Shika Daigaku Fuzoku Byoin","correspondingAuthor":false,"prefix":"","firstName":"Katsuhisa","middleName":"","lastName":"Sunada","suffix":""}],"badges":[],"createdAt":"2020-03-11 16:23:15","currentVersionCode":2,"declarations":"","doi":"10.21203/rs.3.rs-17266/v2","doiUrl":"https://doi.org/10.21203/rs.3.rs-17266/v2","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":802197,"identity":"2c4257ab-7970-48a1-a682-24c2987c43a5","added_by":"auto","created_at":"2020-03-31 15:42:00","extension":"pdf","order_by":0,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":44909,"visible":true,"origin":"","legend":"","description":"","filename":"manuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-17266/v2/manuscript.pdf"},{"id":802198,"identity":"3d6656c7-91a1-4654-9ecd-0a10f8807806","added_by":"auto","created_at":"2020-03-31 15:42:00","extension":"pdf","order_by":0,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":44909,"visible":true,"origin":"","legend":"","description":"","filename":"manuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-17266/v2/manuscript.pdf"},{"id":657068,"identity":"0cbe4321-6635-4e32-9a1b-7fd42dcad3e4","added_by":"auto","created_at":"2020-03-17 14:02:56","extension":"pdf","order_by":0,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":97360,"visible":true,"origin":"","legend":"","description":"","filename":"Theauthorshavewithdrawnthepreprint.pdf","url":"https://assets-eu.researchsquare.com/files/rs-17266/v2/Manuscript.pdf"},{"id":657067,"identity":"9c9b32d8-5549-47ef-9c7d-15535797fa34","added_by":"auto","created_at":"2020-03-17 14:02:47","extension":"pdf","order_by":0,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":36606,"visible":true,"origin":"","legend":"","description":"","filename":"Theauthorshavewithdrawnthepreprint.pdf","url":"https://assets-eu.researchsquare.com/files/rs-17266/v2/The authors have withdrawn the preprint.pdf"},{"id":13493949,"identity":"3bb81166-78ff-463b-b643-f0693d75d93f","added_by":"auto","created_at":"2021-09-16 22:38:52","extension":"pdf","order_by":1,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":136656,"visible":true,"origin":"","legend":"","description":"","filename":"Theauthorshavewithdrawnthepreprint.pdf","url":"https://assets-eu.researchsquare.com/files/rs-17266/v2_covered.pdf"}],"financialInterests":"","formattedTitle":"\u003cp\u003eHemodynamic changes in regular antipsychotic users after adrenaline-containing lidocaine injection under general anesthesia: a prospective study\u003c/p\u003e","fulltext":[],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":false,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":true,"isDeskRejected":"","isHiddenFromSearch":true,"isInQc":false,"isInWorkflow":false,"isPdf":false,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"Adrenaline","lastPublishedDoi":"10.21203/rs.3.rs-17266/v2","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-17266/v2","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003eThe authors have withdrawn this preprint from Research Square\u003c/p\u003e","manuscriptTitle":"Hemodynamic changes in regular antipsychotic users after adrenaline-containing lidocaine injection under general anesthesia: a prospective study","msid":"","msnumber":"","nonDraftVersions":[{"code":2,"date":"2020-03-17 14:02:46","doi":"10.21203/rs.3.rs-17266/v2","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}},{"code":1,"date":"2020-03-16 15:03:18","doi":"10.21203/rs.3.rs-17266/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"e04b6fa2-abc0-4864-a281-f01528f25d7a","owner":[],"postedDate":"March 17th, 2020","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[{"id":70850,"name":"Anesthesiology \u0026 Pain Medicine"}],"tags":[],"updatedAt":"","versionOfRecord":[],"versionCreatedAt":"2020-03-17 14:02:46","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v2","identity":"rs-17266","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-17266","identity":"rs-17266","version":["v2"]},"buildId":"_2-kVJe1T_tPrBINL-cwx","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}

Text is read by the "Ask this paper" AI Q&A widget below. Extraction quality varies by source — PMC NXML preserves structure cleanly, OA-HTML may include some navigation residue, and OA-PDF can have broken hyphenation. The publisher copy (via DOI) is the canonical version.

My notes (saved in your browser only)

Ask this paper AI returns verbatim quotes from the full text · source: preprint-html

Answers must be backed by verbatim quotes from this paper's full text. Hallucinated quotes are dropped automatically; if no verbatim passage answers the question, we say so. How this works

Citation neighborhood (no data yet)

We don't have any in-corpus citations linked to this paper yet. The paper's references may be in our DB but unresolved to ``paper_id`` (resolution happens at ingest when the cited DOI matches a row we already have). Run the cross-source citation reconcile pass to retry.

Source provenance

europepmc
last seen: 2026-05-19T01:45:01.086888+00:00