Mephenamic Acid Treatment Toward Follicles Development and Progesterone

Mefenamat acid is anti-inflammation non steroid which can hamper prostaglandin synthesis in the body tissue by hampering siklooxigen enzyme. The purpose of this research is to find out the influence of mefenamat acid toward the follicles development and progesterone level. This research his experimental laboratory method. The subject of the research divided into five groups randomly selected and  have been homogenized. One group as control group and others as experimental  group with various dos age of Mephenamic Acidtreatment. The data is analyzed to discover average difference the quantity off ollicles and blood progesterone level using one way Anova test. The results of this research is confirmed the significantly difference of  Grafian follicles, yello wish corpus luteumand proges terone level as the influence of Mephenamic Acidin 0.5 mg/kg, 1mg/kg, 1.5  mg/kg, and 2  mg/kg; while there was no significantly difference intertiary follict les development. The decrease of corpus luteumis caused by mefenamat acid activity to hamper the prostaglandin synthesis in the body tissue by hampering siklooxigen enzyme. Prostaglandincan make follicles swelling and cause follicles fracture and make ovulation. The granulosis cell will makecorpus luteumwhich secreted progesterone hormone. Mephenamic Acid was proven to  avoid ovulation that blocked the formation  of yello wish  corpus luteum result ingin the decreased  of blood progesterone level.