Potential Anti-Inflammatory Activity Of Kemangi Leaves (Ocimum Basillicum) in Reducing Folicel Atresia in Musmusculus Mencites Model Endometriosis

In: Jurnal Kesehatan dr. Soebandi · 2025 · vol. 13(2) , pp. 170–177 · doi:10.36858/jkds.v13i2.798 · W4415933542
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This study found that basil leaf extract reduced follicular atresia in an endometriosis mouse model, though not statistically significantly.

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The study investigated whether ethanol extract of kemangi leaves (Ocimum basilicum) reduces follicular atresia in a mouse endometriosis model, using an experimental design with graded-dose therapy and subsequent measurement of follicular atresia. In multilevel dose treatment groups, basil extract administration lowered the average follicular atresia below the control group, but the reduction was not statistically significant; the follicular atresia data were also reported as not normally distributed, leading the authors to use the Kruskal-Wallis test (reported p>0.05, with value 0.187). A major limitation explicitly noted by the authors is that the duration of dosing administration was not established and further research is needed on treatment duration. This paper is centrally about endometriosis — it tests Ocimum basilicum leaf extract for effects on follicular atresia in an endometriosis mouse model.

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Abstract

Endometriosis is ai chronic diseaise chairaicterized by the development of endometriail stromai. Paitients with endometriosis aire chairaicterized by pelvic paiin aind infertility, which is ai heailth threait to women aind aidolescents. Baisil leaives (Ocimuim baisillicuim) is ain airomaitic plaint thait contaiins citrail which is known to haive ainti-inflaimmaitory aictivity. The puirpose of this stuidy is to determine the decreaise in Folike Aitresiai in Mice Muismuiscuiluis Endometriosis Model. Methods: This stuidy uised experimentail reseairch with endometriosis mice thait were given graided dose treaitment theraipy aind then saiw ai decreaise in follicuilair aitresiai. The resuilts of the ainailysis of follicuilair aitresiai showed thait the aidministraition of ethainol extraict ofBaisil leaives (Ocimuim Baisilicuim) in the muiltilevel dose treaitment grouip wais clinicailly aible to reduice the aiveraige follicuilair aitresiai still below the control grouip, ailthouigh not staitisticailly significaint. The distribuition of follicuilair aitresiai daitai is not normailly distribuited so it is done with the Kruiskail Waillis test. The Kruiskail Waillis test resuilts showed ai vailuie of 0.187 (p>0.05). Concluision ainti- inflaimmaitory in baisil leaives (Ocimuim Baisilicuim) is aible to reduice follicuilair aitresiai in endometriosis model mice ailthouigh not staitisticailly significain so further research is needed regarding the duration of dosage administration.
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Potential Anti-Inflammatory Activity Of Kemangi Leaves (Ocimum Basillicum) in Reducing Folicel Atresia in Musmusculus Mencites Model Endometriosis DOI: https://doi.org/10.36858/jkds.v13i2.798Keywords: Basil Leaf (Ocimum Basilicum),, endometriosis, folicularAbstract Endometriosis is ai chronic diseaise chairaicterized by the development of endometriail stromai. Paitients with endometriosis aire chairaicterized by pelvic paiin aind infertility, which is ai heailth threait to women aind aidolescents. Baisil leaives (Ocimuim baisillicuim) is ain airomaitic plaint thait contaiins citrail which is known to haive ainti-inflaimmaitory aictivity. The puirpose of this stuidy is to determine the decreaise in Folike Aitresiai in Mice Muismuiscuiluis Endometriosis Model. Methods: This stuidy uised experimentail reseairch with endometriosis mice thait were given graided dose treaitment theraipy aind then saiw ai decreaise in follicuilair aitresiai. The resuilts of the ainailysis of follicuilair aitresiai showed thait the aidministraition of ethainol extraict ofBaisil leaives (Ocimuim Baisilicuim) in the muiltilevel dose treaitment grouip wais clinicailly aible to reduice the aiveraige follicuilair aitresiai still below the control grouip, ailthouigh not staitisticailly significaint. The distribuition of follicuilair aitresiai daitai is not normailly distribuited so it is done with the Kruiskail Waillis test. The Kruiskail Waillis test resuilts showed ai vailuie of 0.187 (p>0.05). Concluision ainti- inflaimmaitory in baisil leaives (Ocimuim Baisilicuim) is aible to reduice follicuilair aitresiai in endometriosis model mice ailthouigh not staitisticailly significain so further research is needed regarding the duration of dosage administration. References A’yuni, D. Q., Sa’adi, A., & Widjiati, W. (2023). 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