Sperm chromatin structure assay results after swim-up are related only to embryo quality but not to fertilization and pregnancy rates following IVF.

Niu ZH, Shi HJ, Zhang HQ, Zhang AJ, Sun YJ, Feng Y
Asian journal of andrology · 2011 · doi:10.1038/aja.2011.77 · PMID:21841807 · PMC3739549
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This study found that sperm chromatin structure assay results after swim-up correlate with lower good embryo rates but not fertilization or pregnancy rates, indicating their limited value in predicting IVF outcomes.

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This study evaluated the predictive value of sperm chromatin structure assay results, specifically DNA fragmentation index and high DNA stainability, on outcomes for 223 couples undergoing in vitro fertilization. The researchers compared fertilization rates, embryo quality, and pregnancy success across different subgroups based on these sperm parameters after swim-up preparation. They found no significant differences in fertilization or clinical pregnancy rates between groups, but observed that abnormal DNA fragmentation was associated with a lower rate of good-quality embryos. The paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.

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Abstract

The aim of this study was to investigate whether the sperm chromatin structure assay (SCSA) results after swim-up are related to fertilization rates, embryo quality and pregnancy rates following in vitro fertilization (IVF). A total of 223 couples undergoing IVF in our hospital from October 2008 to September 2009 were included in this study. Data on the IVF process and sperm chromatin structure assay results were collected. Fertilization rate, embryo quality and IVF success rates of different DNA fragmentation index (DFI) subgroups and high DNA stainability (HDS) subgroups were compared. There were no significant differences in fertilization rate, clinical pregnancy or delivery rates between the DFI and HDS subgroups. However, the group with abnormal DFI had a lower good embryo rate. So, we concluded that the SCSA variables, either DFI or HDS after swim-up preparation, were not valuable in predicting fertilization failure or pregnancy rate, but an abnormal DFI meant a lower good embryo rate following IVF.
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| Volume 13, Issue 6 (November 2011) 13, 862–866; 10.1038/aja.2011.77 Sperm chromatin structure assay results after swim-up are related only to embryo quality but not to fertilization and pregnancy rates following IVF Zhi-Hong Niu1, Hui-Juan Shi2, Hui-Qin Zhang2, Ai-Jun Zhang1, Yi-Juan Sun1 and Yun Feng1 1 IVF Unit, Department of Obstetrics and Gynecology, Ruijin Hospital Affiliated to Shanghai Jiao Tong University, Shanghai 200025, China 2 Shanghai Institute of Planned Parenthood Research, Shanghai 200032, China Correspondence: Dr Y Feng, ([email protected]) Received 21 February 2011; Revised 28 March 2011; Accepted 29 April 2011; Published online 15 August 2011 | Abstract | | The aim of this study was to investigate whether the sperm chromatin structure assay (SCSA) results after swim-up are related to fertilization rates, embryo quality and pregnancy rates following in vitro fertilization (IVF). A total of 223 couples undergoing IVF in our hospital from October 2008 to September 2009 were included in this study. Data on the IVF process and sperm chromatin structure assay results were collected. Fertilization rate, embryo quality and IVF success rates of different DNA fragmentation index (DFI) subgroups and high DNA stainability (HDS) subgroups were compared. There were no significant differences in fertilization rate, clinical pregnancy or delivery rates between the DFI and HDS subgroups. However, the group with abnormal DFI had a lower good embryo rate. So, we concluded that the SCSA variables, either DFI or HDS after swim-up preparation, were not valuable in predicting fertilization failure or pregnancy rate, but an abnormal DFI meant a lower good embryo rate following IVF. Keywords: embryo; fertilization; in-vitro fertilization; sperm chromatin structure assay PDF | PDF | 中文摘要 | | | | | Browse: 4537 | |

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