Genome-Resolved Antibacterial Immune Response Conserved in Juvenile and Adult Sunflower Sea Stars

Genome-Resolved Antibacterial Immune Response Conserved in Juvenile and Adult Sunflower Sea Stars | Authorea try { document.documentElement.classList.add('js'); } catch (e) { } var _gaq = _gaq || []; _gaq.push(['_setAccount', 'G-8VDV14Y67G']); _gaq.push(['_trackPageview']); (function() { var ga = document.createElement('script'); ga.type = 'text/javascript'; ga.async = true; ga.src = ('https:' == document.location.protocol ? 'https://ssl' : 'http://www') + '.google-analytics.com/ga.js'; var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(ga, s); })(); Skip to main content Preprints Collections Wiley Open Research IET Open Research Ecological Society of Japan All Collections About About Authorea FAQs Contact Us Quick Search anywhere Search for preprint articles, keywords, etc. Search Search ADVANCED SEARCH SCROLL This is a preprint and has not been peer reviewed. Data may be preliminary. 1 April 2026 V1 Latest version Share on Genome-Resolved Antibacterial Immune Response Conserved in Juvenile and Adult Sunflower Sea Stars Authors : Grace Crandall 0000-0002-6249-4240 [email protected] , Alyssa Gehman , Katherine Davis , Melanie Prentice , Drew Harvell , Samuel J White , Paul Hershberger , and Steven Roberts Authors Info & Affiliations https://doi.org/10.22541/au.177502918.81646805/v1 132 views 90 downloads Contents Abstract Supplementary Material Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Sea star wasting disease (SSWD) has impacted over twenty sea star species along the Northeast Pacific Coast, with some seemingly more susceptible than others. The once common sunflower sea star, Pycnopodia helianthoides, has been driven to endangerment. Observations from natural SSWD outbreaks have indicated higher mortality rates in adults than juveniles, suggesting that susceptibility may be age-dependent. The hypothesis of age-related differences in immunity was assessed by challenging both juvenile and adult P. helianthoides in controlled laboratory exposures to SSWD. Using a transcriptomic approach, we compared the immune response of adult and juvenile P. helianthoides exposed to SSWD in two independent disease challenge trials. In both trials, all disease-exposed sea stars showed disease signs consistent with SSWD with no observable differences in outcome across age class, although age-driven differentially expressed genes were identified, related to development, signaling, differentiation, and stress and metabolism regulation. Transcriptomic sequencing datasets showed a majority of differentially expressed genes were shared across the two experiments, suggesting a core response to SSWD that did not differ between age classes in the second trial. Functional annotation identified a core immune response to bacterial pathogens. Supplementary Material File (crandall_etal_2026.docx) Download 2.71 MB Information & Authors Information Version history V1 Version 1 01 April 2026 Copyright This work is licensed under a Non Exclusive No Reuse License. Keywords genetics invertebrate laboratory marine molecular genetics Authors Affiliations Grace Crandall 0000-0002-6249-4240 [email protected] University of Washington School of Aquatic and Fishery Sciences View all articles by this author Alyssa Gehman Hakai Institute View all articles by this author Katherine Davis Hakai Institute View all articles by this author Melanie Prentice Hakai Institute View all articles by this author Drew Harvell University of Washington Friday Harbor Laboratories View all articles by this author Samuel J White University of Washington School of Aquatic and Fishery Sciences View all articles by this author Paul Hershberger U.S. Geological Survey, Western Fisheries Research Center, Marrowstone Marine Field Station; Nordland, WA, USA View all articles by this author Steven Roberts University of Washington School of Aquatic and Fishery Sciences View all articles by this author Metrics & Citations Metrics Article Usage 132 views 90 downloads .FvxKWukQNSOunydq8rnd { width: 100px; } Citations Download citation Grace Crandall, Alyssa Gehman, Katherine Davis, et al. Genome-Resolved Antibacterial Immune Response Conserved in Juvenile and Adult Sunflower Sea Stars. Authorea . 01 April 2026. DOI: https://doi.org/10.22541/au.177502918.81646805/v1 If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download. For more information or tips please see 'Downloading to a citation manager' in the Help menu . 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