The Tri-Electrical Axis: Integrating Heart, Brain, and Gut Electrophysiology in the Age of AI

The human body operates through complex bioelectrical systems, with the heart, brain, and gastrointestinal tract each generating distinct electrical signals. While Electrocardiography (ECG) and Electroencephalography (EEG) have long served as essential diagnostic tools, Electroenterography (EEnG) remains underutilized due to methodological challenges. Recent advances in systems physiology suggest that these three organs may not function in isolation but rather interact through a shared bioelectrical framework. In this review, we introduce the concept of the Tri-Electrical Axis - a proposed integrative network reflecting synchronized electrophysiological activity across the cardiac, cerebral, and enteric systems. We also tentatively define a central point of interaction within this axis as the Belviranli Junction, representing a novel physiological nexus. The integration of artificial intelligence (AI) into this framework holds promise for decoding complex multi-organ patterns, enabling real-time systemic monitoring and advancing precision diagnostics. This work synthesizes current literature, identifies critical gaps, and offers a forward-looking perspective on how multi-organ bioelectrical integration, supported by AI, may reshape future medical diagnostics and physiological understanding.