Enhanced transplantability of human ovarian cancer lines in cyclophosphamide-pretreated nude mice

M M Nauta, E Boven, H M Schlüper, C A Erkelens, H M Pinedo

British journal of cancer · 1986 · doi:10.1038/bjc.1986.181 · PMID:3017398 · PMC2001520

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This study investigated the enhanced transplantability of human ovarian cancer cell lines in nude mice following pretreatment with cyclophosphamide.

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The paper evaluated whether cyclophosphamide pretreatment of nude mice could enhance the ability to engraft and transplant human ovarian cancer cell lines as xenografts. Using cyclophosphamide-pretreated versus untreated nude mice, the authors reported improved transplantability in the pretreated group, indicating a higher success rate for establishing tumor take. A major limitation is that the study is focused on xenograft engraftment performance rather than on underlying tumor biology or therapeutic efficacy. This paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.

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This is a preview of subscription content, access via your institution Access options Subscribe to this journal Receive 24 print issues and online access 251,40 € per year only 10,48 € per issue Buy this article - Purchase on SpringerLink - Instant access to the full article PDF. 39,95 € Prices may be subject to local taxes which are calculated during checkout Rights and permissions About this article Cite this article Nauta, M., Boven, E., Schlüper, H. et al. Enhanced transplantability of human ovarian cancer lines in cyclophosphamide-pretreated nude mice. Br J Cancer 54, 331–335 (1986). https://doi.org/10.1038/bjc.1986.181 Issue date: DOI: https://doi.org/10.1038/bjc.1986.181 This article is cited by - Human tumor xenografts as model for drug testing CANCER AND METASTASIS REVIEW (1988)

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Condition tags

endometriosis

MeSH descriptors

Cyclophosphamide Killer Cells, Natural Ovarian Neoplasms Adenocarcinoma Adenocarcinoma Adenocarcinoma, Mucinous Adenocarcinoma, Mucinous Animals Cell Line Cyclophosphamide Cystadenocarcinoma Cystadenocarcinoma Endometriosis Endometriosis Female Humans Killer Cells, Natural Mice Mice, Nude Neoplasm Transplantation

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SciLite annotations

organisms 2

human transgenic mice

chemicals 1

cyclophosphamide

Source provenance

europepmc: last seen: 2026-06-13T06:22:48.782012+00:00
pubmed: last seen: 2026-05-13T22:09:35.489789+00:00
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