Expression levels and clinical significance of YKL-40 in serum and peritoneal fluid of patients with endometriosis
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by claude@2026-06, 2026-06-08
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Serum and peritoneal fluid levels of YKL-40 were significantly higher in endometriosis patients compared to controls and correlated positively with CA125.
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by claude@2026-06, 2026-06-09
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This study measured serum and peritoneal fluid YKL-40 and CA125 in 50 confirmed endometriosis patients and compared them with 40 controls with benign uterine tumors, using ELISA for YKL-40 and electrochemiluminescence for CA125, followed by statistical comparisons and Spearman correlation. YKL-40 and CA125 levels were higher in the endometriosis group than in controls (P<0.05), and within endometriosis, patients with stage III–IV had higher levels than those with stage I–II (P<0.05). The paper also found a significant positive correlation between serum and peritoneal fluid YKL-40 and CA125 in endometriosis patients (r=0.504 and 0.401; P<0.01). A limitation explicitly noted from the provided text is the small sample size and the use of benign uterine tumor controls rather than another pelvic-pain comparator group. This paper is centrally about endometriosis—specifically, assessing serum and peritoneal fluid YKL-40 (and CA125) as diagnostic and stage-indicative biomarkers.
Abstract
Objective
To investigate the expression levels of YKL-40 and CA125 in the serum and peritoneal fluid of patients with endometriosis (EMS), and discuss the relationship between YKL-40, and CA125.
Methods
From March 2012 to March 2014, a total of 50 cases with EMS were included into this study (EMS group). At the same time, another 40 cases with benign uterus tumor were included into control group. There were no significant differences between two groups in the aspects of age, body mass index, the constituent ratio of algomenorrhea, the constituent ratio of infertility, and duration of infertility (P>0.05). The study protocol was approved by the Ethical Review Board of Investigation in Human Being of Xuzhou Central Hospital, Affiliated Reproductive Medical Central of Southeast University. Informed consent was obtained from each patient. Serum and peritoneal fluid levels of YKL-40 in both two groups were detected by enzyme-linked immunosorbent assay (ELISA), and serum and peritoneal fluid levels of CA125 were detected by electrochemiluminescence method. The relationship between CA125, YKL-40 and EMS were analyzed by Spearman correlation analysis.
Results
①The serum and peritoneal fluid levels of CA125 and YKL-40 in EMS group were both significantly higher than those of control group, which with significant differences (P<0.05). ②The serum and peritoneal fluid levels of CA125 and YKL-40 in stage Ⅲ-Ⅳ of EMS group were significantly higher than those of stage Ⅰ-Ⅱ, which with significant differences (P<0.05). The serum levels of YKL-40 in stage Ⅰ-Ⅱ, stage Ⅲ-Ⅳwere significantly higher than those of control group, and the peritoneal fluid levels of YKL-40, CA125 in stage Ⅰ-Ⅱ, stage Ⅲ-Ⅳwere significantly higher than those of control group, respectively, which both with significant differences (P<0.05). ③Serum and peritoneal fluid levels of YKL-40 showed positive correlation with CA125 (r=0.504, 0.401; P<0.01) by Spearman correlation analysis (P<0.05).
Conclusions
The serum and peritoneal fluid levels of YKL-40 might be an useful diagnosing and prompting clinical staging biomarker of EMS.
Key words:
Endometriosis; YKL-40; Clinical staging
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endometriosisinfertility
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