Understanding the mismatch between in-vivo and in-silico rhinomanometry

Abstract Numerical simulations and clinical measurements of nasal resistance are in quantitative disagreement. Bias introduced by the design of medical devices has not been considered until now as a possible explanation. The aim of present paper is to study the effect of the location of the probe on the rhinomanometer that is meant to measure the ambient pressure. Rhinomanometry is carried out on a 3D silicone model of a patient-specific anatomy; a clinical device and dedicated sensors are employed side-by-side for mutual validation. The same anatomy is also employed for numerical simulations, with approaches spanning a wide range of fidelity levels. We find that the intrinsic uncertainty of the numerical simulations is of minor importance. To the contrary, the position of the pressure tap intended to acquire the external pressure in the clinical device is crucial, and can cause a mismatch comparable to that generally observed between in-silico and in-vivo rhinomanometry data. A source of systematic bias may therefore exist in rhinomanometers, designed under the assumption that measurements of the nasal resistance are unaffected by the flow development within the instruments. Competing Interest Statement The authors have declared no competing interest.