Maternal MTHFR C677T polymorphism does not affect live birth rate following IVF in Chinese Han population: a retrospective cohort study of 1265 women

Maternal MTHFR C677T polymorphism does not affect live birth rate following IVF in Chinese Han population: a retrospective cohort study of 1265 women | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Help Center Sign In Submit a Preprint Cite Share Download PDF Research Maternal MTHFR C677T polymorphism does not affect live birth rate following IVF in Chinese Han population: a retrospective cohort study of 1265 women Hong Zeng, Hebin Xie, Dongmei He, Yuhao Zhao, Nenghui Liu This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.2.22704/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Backgrounds: MTHFR is a key enzyme for folic acid metabolism and is important for reproduction. However, whether MTHFR C677T genotype affect live birth rate following IVF is unknown. This study aims to evaluate the association of MTHFR C677T polymorphism and live birth rate following IVF. Methods: This is a retrospective cohort study of 1265 women undergoing first IVF -ET cycle (2015-2017) in Reproductive Medicine Center of Xiangya Hospital. The patients were followed for a minimum of 2 years and maximum of 5 years, the observation endpoint is live birth, or all the embryos derived from the first stimulation cycle are transferred. The study population was divided into three groups based on MTHFR C677T genotype (MTHFR 677CC, MTHFR 677CT, MTHFR 677TT). The primary outcomes are live birth rate and cumulative live birth. The secondary outcomes including laboratory parameters (number of oocytes, number of 2PNs, number of available embryos, number of good embryos) and clinical parameters (chemical pregnancy rate, clinical pregnancy rate, implantation rate, preclinical pregnancy loss rate, miscarriage rate). The logistic regression analysis with different adjusted models were used to analyze the association of MTHFR C677T genotype and live birth. Results: Among the 1265 participants, 541 were MTHFR 677CC genotype, 585 were MTHFR 677CT genotype, and 139 were MTHFR 677TT genotype. The live birth rate was 43.6%, 44.8%, and 40.3% (p-value = 0.63), and the cumulative live birth rate per stimulation cycle was 54.7%, 53.5%, and 51.8% (p-value =0.81) in MTHFR 677CC group, MTHFR 677CT group, and MTHFR 677TT group, respectively. The secondary laboratory outcomes and clinical outcomes were not significantly different between the three groups. Logistic regression analysis showed no significant association of MTHFR C677T genotype and live birth whether in model 1 (p-value for trend = 0.63) , model 2 (p-value for trend = 0.63), or model 3 (p-value for trend = 0.59). Conclusions: MTHFR C677T genotype does not significantly affect live birth rate and cumulative live birth rate following first IVF in Chinese Han couples. Endocrinology & Metabolism 5 10-methylenetetrahydrofolate reductase polymorphism live birth rate ART outcome Figures Figure 2 Background 5,10-methylenetetrahydrofolate reductase (MTHFR) is a key enzyme for folic acid. MTHFR catalyzes 5,10-methylenetetrahydrofolate to 5-methylenetetrahydrofolate, the latter is the predominant circulating form of folate, which is essential for the synthesis of nucleotide and S-adenosylmethionine, the re-methylation of homocysteine (hcy) to methionine, the methylation of DNA, proteins, neurotransmitters and phospholipids [ 1 , 2 ]. There are implications that a wide range of diseases (thrombophic disease, ischemic stroke, diabetes, leukemia, colorectal cancer, breast cancer, ovarian cancer, and so on) are related with MTHFR polymorphisms [ 3 – 7 ]. More than 20 polymorphisms of MTHFR have been described [ 8 ]. MTHFR C677T (rs1801133) is one of the most investigated polymorphisms. The MTHFR 677C > T transition causes an alanine to valine replacement (Ala222Val) in the catalytic domain of MTHFR, which leads to reduced MTHFR activity, MTHFR 677CT and MTHFR 677TT have in vitro MTHFR activity reduced by about 70% and 35%, respectively [ 9 ]. Reduced MTHFR activity has a negative effect on reproductive functions as oocyte and embryo development, endometrial receptivity, embryo implantation, and the maintenance of pregnancy [ 10 , 11 ]. Evidences showed that MTHFR 677C > T is associated with ovarian reserve, implantation failure, pregnancy loss, human subfertility and infertility, oocyte maturation, embryo aneuploid [ 12 – 14 ], MTHFR 677C > T mutation is also risk factor for premature ovarian failure [ 15 ], recurrent miscarriage and implantation failures [ 14 ] preterm birth [ 16 ]. However, the role of MTHFR C677T genotype on ART outcomes remained unclear. Despite that several studies evaluated the relationship of MTHFR C677T polymorphism and pregnancy outcome following IVF [ 17 – 19 ], the results remained controversial. Besides, most of the studies included a small sample size, and no studies reported outcome of live birth rate. Therefore more definitive data with larger sample size and long-term ART outcomes are needed to evaluate whether MTHFR C677T polymorphism affect ART outcomes. In this study, we evaluate the relationship of MTHFR C677T polymorphism with live birth rate and the cumulative live birth. To evaluate the relationship of MTHFR C677T polymorphism and live birth, the logistic regression analysis was performed using both unadjusted model and 2 models adjusted by different confounding factors. Materials And Methods This was a retrospective cohort study of women undergoing their first in-vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) and fresh embryo transfer (ET) cycle at Reproductive Medicine Center of Xiangya Hospital from 2015 to 2017. Data were collected through the electronic records. This study was approved by the Ethics committee of Xiangya Hospital. The study population was divided into three groups based on the results of MTHFR C677T genotyping ( MTHFR 677CC, MTHFR 677CT, and MTHFR 677TT). Inclusion criteria Women undergoing their first IVF/ICIS and fresh ET cycle; The couple are Chinese Han nationality; 1~2 good embryos transferred to the patients at Day 3; 18 kg/m 2 ≤ BM I≤ 25 kg/m 2 ; Maternal age ≤ 45 years. Exclusion criteria Abnormal karyotype in any of the couple. Thyroid dysfunction. Severe Hydrosalpinx. Intrauterine adhesions. Myoma>5cm. Donor cycles. ART procedure Controlled ovarian stimulation (COS) was performed using recombinant FSH (rFSH) with or without human Menopausal Gonadotrophin (HMG), or urinary FSH (uFSH) with or without HMG, under pituitary suppression by Gonadotrophin releasing hormone analogue (GnRHa). The choice of starting gonadotrophin (Gn) was based on maternal age, BMI, Basal FSH concentration, AMH concentration, then Gn dose can be adjusted according to patients’ response during COS. The COS protocol was decided according to the physicians’ clinical experience and ART indications. For GnRHa long protocol, Triptorelin (Diphereline, France; 0.25mg/d subcutaneous injection) starting from the middle luteal phase of the previous cycle. After two weeks, pituitary suppression was verified (follicular diameter < 5 mm, endometrial thickness < 5 mm, serum estradiol < 50 pg/mL, serum FSH < 5 IU/L, serum LH < 5 IU/L) before starting COS. For GnRHa short protocol, Triptorelin was started at a subcutaneous dose of 0.25mg/d at Day 2, COS was started at Day 3. For ultra-long protocol, the first injection of Leuprorelin (Livzon Corp., Shanghai, China, 3.75mg, subcutaneously) was given to patients, 4 weeks later, the second Leuprorelin (, 3.75mg, subcutaneously) was given, 3-4 weeks later, COS was started if down-regulation was satisfied. Follicular development was monitored by transvaginal ultrasound and serum estradiol (E2). Measurements performed every 2-3 days from stimulation day 5-6. Ovulation was triggered by injecting 10,000 international units (IU) of hCG (Livzon Corp., Shanghai, China) intramuscularly when at least 1 follicle reached 18 mm, or at least 3 follicles reached 16 mm. After 36 hours of hCG injection, ultrasound guided transvaginal oocyte aspiration (OPU) was performed. Luteal phase support was performed at the day of OPU. Embryos were transferred at Day 3. All the patients were supplemented with 800 mg folic acid from embryo transfer (ET) day to 12 gestational weeks if pregnancy is established. Sample collection and MTHFR C677T genotyping Peripheral blood was collected from every women before ART treatment. Genomic DNA was extracted from blood using the QIAamp DNA Blood Mini Kit (Qiagen, Hilden, Germany). Reverse transcription-polymerase chain reaction (RT-PCR) was used to determine the genotype of MTHFR C677T. Statistical analysis The categorical variables were presented as frequencies and percentages, the continuous variables were presented as means and standard deviations (SDs) or interquartile ranges (IQRs) depending on whether the data distribution was normal. . We compared categorical variables between groups using χ 2 testing, and we compared continuous variables using analysis of variance (ANOVA) or the Kruskal-Wallis test according to distribution type. We evaluated the relationship of MTHFR 677 genotype and live birth using logistic regression model with and without adjusting the confounding factors that may have expected influence on our outcome. We used 3 models in total, including model 1, unadjusted; model 2, adjusted for age and BMI, for model 3, adjusted model 2 for infertility type, stimulation protocol, ART indication, miscarriage history, and endometrial thickness. All statistical analyses were 2-sided, and we considered a p -value of less than 0.05 to be statistically significant. The statistical analyses were performed by SPSS (version 25, Chicago, USA). Hardy-Weinberg equilibrium (HWE) was examined using the StataSE software (version 15.0, Stata Corp., USA). Deviation from HWE was confirmed if p -value < 0.05. Outcomes and definitions The primary outcomes were live birth rate, and cumulative live birth rate per stimulation cycle. The secondary outcomes including laboratory outcomes ( number of oocytes, number of 2PNs, number of available embryos, number of good embryos) and clinical outcomes (chemical pregnancy rate, clinical pregnancy rate, implantation rate, preclinical pregnancy loss rate, miscarriage rate). Chemical pregnancy cases were defined as increased serum HCG levels (>10 IU/L) at 12 days after embryo transfer. clinical pregnancy was confirmed by ultrasonographic visualization of gestational sacs 4–5 weeks after embryo transfer. Implantation rate was calculated as the gestational sac number divided by the transferred embryos number. We defined preclinical pregnancy loss as cases who was chemical pregnancy but not reached clinical pregnancy. Miscarriage was defined as spontaneous clinical pregnancy loss before 24 gestational weeks. Live birth was defined as birth of at least one newborn after 24 weeks’ gestation that exhibits any sign of life. We also reported the cumulative live birth a stimulation cycle at 24 months after their first oocyte retrieve cycle. Results Of the initial cohort of 1756 women, the following patients were excluded: cycle cancelled (n=23), all embryos cryopreserved (n=79), Abnormal karyotype (n=19), Not Chinese Han population (n=34), Thyroid dysfunction (n=75), Severe Hydrosalpinx (n=21), Intrauterine adhesion (n=47), Myoma>5cm (n=26), BMI25 kg/m 2 (n=51), Maternal age>45 years (n=38), Embryos not transferred at D3 (n=43), Loss to follow-up (n=12), incomplete data (n=23). After all exclusion, a total of 1265 women remained. Based on the results of MTHFR C677T genotyping, 541 women were included in MTHFR 677CC group, 585 women were included in MTHFR 677CT group, 139 women were included in MTHFR 677TT groups (Fig 1). There was no deviation from HWE in this cohort population ( p -value = 0.31). Baseline characteristics Baseline parameters including maternal age, BMI, duration of infertility, type of infertility, ART indication, miscarriage history, serum AMH, AFC, fertilization method, stimulation protocol, starting Gn does, total Gn does, days of stimulation, endometrial thickness, endometrial pattern, estradiol level at hCG day, LH level at hCG day, progesterone level at hCG day, number of transferred embryos. All the baseline parameters were not significantly different between the three groups (Table 1). Live birth rate and cumulative live birth rate. The live birth rate per fresh ET cycle was 43.6%, 44.8%, and 40.3% in MTHFR 677CC group, MTHFR 677CT group, and MTHFR 677TT group respectively, without significant difference ( p -value = 0.63) (Table 2). The cumulative live birth rate per stimulation cycle was 54.7%, 53.5%, and 51.8% respectively, without significant difference ( p -value =0.81) (Table 2). Secondary laboratory and clinical outcomes The secondary laboratory outcomes including number of oocytes obtained, number of 2PNs, number of available embryos, number of good embryos. All the laboratory outcomes were not significantly different between the three groups (Table 2). The secondary clinical outcomes including implantation rate, chemical pregnancy rate, clinical pregnancy rate, preclinical pregnancy loss rate, miscarriage rate. All the clinical outcomes were not significantly different between the three groups (Table 2) . Association of MTHFR C677T genotype and live birth The logistical regression analyses showed no significant association of MTHFR C677T genotype with live birth whether under unadjusted model 1 ( p -value for trend = 0.63; CT: OR 1.15, 95%CI 0.79-1.68; TT: OR 1.20, 95%CI 0.83-1.75), model 2 adjusted by maternal age, BMI ( p -value for trend = 0.63, CT: OR 1.13, 95%CI 0.77-1.67; TT: OR 1.20; 95%CI 0.82-1.76), or model 3 adjusted by maternal age and BMI, and model 2 which adjusted by maternal age, BMI, infertility type, stimulation protocol, ART indication, miscarriage history, and endometrial thickness ( p -value for trend = 0.59; CT: OR 1.20, 95%CI 0.81-1.77; TT: OR 1.23, 95%CI 0.83-1.80) (Table 3). Discussion MTHFR is a pivotal gene for folate metabolism and is essential for human reproduction. Previous evidences showed that variants in MTHFR C677T modify the serum concentrations of folate and homocysteine, and may affect IVF outcomes. However, the results remained quite conflicting. Several studies reported a negative effect of MTHFR 677TT genotype on ART outcomes. Laanpere et al. reported that MTHFR 677TT individuals had a lower proportion of good-quality embryos and a decreased chance of pregnancy [ 19 ]. Enciso et al. found that patients with MTHFR 677C > T variant showed a higher rate of aneuploid embryos and a lower rate of implantation [ 13 ], Pavlik et al. observed an association of MTHFR 677TT genotype with higher serum AMH levels but lower number of oocytes retrieved [ 20 ]. However, Delia et al. demonstrated a significant effect of MTHFR C677T polymorphism on oocyte maturity and recovery in Brazilian women,but not affect normal fertilization, good-quality embryo, and clinical pregnancy rate [ 17 ]. Dobson et al. found no significant association of MTHFR C677T polymorphism with number of embryos, quality of embryos, and ongoing pregnancy rate [ 18 ]. Results of our study showed that maternal MTHFR C677T genotype does not affect live birth rate, cumulative live birth rate per stimulation cycle, and other ART outcomes including laboratory outcomes (number of oocytes, number of 2PNs, number of available embryos, number of good embryos) and clinical outcomes (chemical pregnancy rate, clinical pregnancy rate, implantation rate, preclinical pregnancy loss rate, miscarriage rate) in Chinese Han couples following their first IVF-ET cycle, indicating that maternal MTHFR C677T genotype does predict ART outcomes in Chinese Han couple. Huang et al. in 2019 conducted a randomized trials on folic acid supplementation in oligozoospermic men with MTHFR 677 TT genotype, they found that 3 months’ supplementation of folic acid significantly decreased the seminal MDA and sperm DNA fragmentation index (DFI), and increased spontaneous pregnancy rate and live birth rate, but folic acid supplementation did not exhibit any advantage in MTHFR 677CT genotype [ 21 ]. An explanation of our negative results is that, all the included women were regularly supplemented with 800 mg folic acid at the day of embryo transfer, if establishment of pregnancy is confirmed, the folic acid supplementation lasted for 3 months. Maybe it is the supplementation of folic acid increased the ART outcomes and then make the difference disappear. However, Murto et al. found that folic acid intake or folate status did not affect serum Hcy level and ART outcomes including chemical pregnancy, clinical pregnancy, miscarriage and livebirth [ 22 ]. In spite of this, maternal MTHFR C677T genotype is not recommended for Chinese Han population undergoing their first IVF-ET cycle and supplemented with 800 mg folic acid. Why our results are different from the others can be elucidated as following: (1) The effect of different ethnicity and nationality, for ethnicity and nationality may significantly affect genetic susceptibility. (2) Different inclusion and exclusion criteria. Our study exclude the high-risk factors that affect ART outcomes. (3) Adjusting for confounding factors. Some studies did not adjust the confounding factors, or only adjust limited factors. While our study evaluate the association of MTHFR C677T genotype with live birth by 3 model, including model 1 (unadjusted), model 2 (adjusted for age and BMI), and model 3 (adjusted model 2 for infertility type, stimulation protocol, ART indication, miscarriage history, and endometrial thickness). The results of the three models are in consistent. (4) Sample size. Our study consist of 1265 patients, the sample size is so far the largest. However, most of the previous studies consist of small sample size. Besides, our study has the following strengths: The completeness of case data and the long-term follow-up, we have a minimum follow-up of 2 years and maximum of 5 years after the patients’ first IVF cycle, the endpoint of live birth tracked down until the embryo used up after first IVF cycle. As far as we know, this is the first article that evaluate the association of maternal MTHFR C677T genotype with live birth and cumulative live birth following IVF. However, there are some limitations in the study: (1) The biggest limitation of this study is its retrospective nature. However, our inclusion and exclusion are very rigorous to control the influence of risk factors, and we perform a robust statistical analysis to control other confounding factors. Besides, the completeness of patents’ information is satisfied and the follow-up term is long. Therefore, the results from this study should not be significantly affected. (2) The effect of male partner’s MTHFR C677T polymorphism was not considered; (3) The combination effect of haplotype of different MTHFR polymorphisms was not considered. (4) the combination effect of other genetic polymorphisms in the pathway of folic acid metabolism was not considered. (5) Serum folate and homocysteine levels were not detected. Further studies are needed to evaluate the role of male partner’s MTHFR genotype, the combination role of different genetic polymorphisms in the pathway of folic acid metabolism, and the interaction of serum vitamin B12, folate, hcy with MTHFR genotypes on ART outcomes, as well as on pregnancy complication of preeclampsia, and perinatal outcomes. Conclusions Maternal MTHFR C677T genotyping alone does not significantly affect live birth rate and cumulative live birth rate following first IVF-ET cycle in Chinese Han couples. We should be very cautious to extrapolate the results to other ethnicity populations, and we can’t extrapolate the results to patients who did no supplemented with folic acid. Abbreviations MTHFR 5,10-methylenetetrahydrofolate reductase, IVF = in-vitro fertilization, ICSI = intracytoplasmic sperm injection, ET = embryo transfer, ART = assisted reproduction technology, Declarations Ethics approval and consent to participate: The study is approved by the Ethics Committee of Xiangya Hospital. This is a retrospective analysis, and no consent was signed by the patients. Availability of data and materials: The data sets used and/or analyzed during the current study are available from the corresponding author on reasonable request. Consent for publication: Not applicable Competing interests: The authors declare they have no competing interests Funding: This study was funded by the National Natural Science Foundation of China (http://www.nsfc.gov.cn/) (grant number 81571441). Author’s contributions: Zeng. designed the study, draft the manuscript, tables and figures; Xie. performed the statistical analyses; He. and Zhao. Collected the participants’ information; Liu. designed the study and revised the manuscript. References Turgal M, Gumruk F, Karaagaoglu E, et al. Methylenetetrahydrofolate Reductase Polymorphisms and Pregnancy Outcome . Geburtshilfe Frauenheilkd. 2018;78(9):871-8. Kim SY, Park SY, Choi JW, et al. Association between MTHFR 1298A>C polymorphism and spontaneous abortion with fetal chromosomal aneuploidy . Am J Reprod Immunol. 2011;66(4):252-8. Qin X, Spence JD, Li J, et al. Interaction of serum vitamin B12 and folate with MTHFR genotypes on risk of ischemic stroke . Neurology. 2020. Qin X, Li Y, Yuan H, et al. Relationship of MTHFR gene 677C --> T polymorphism, homocysteine, and estimated glomerular filtration rate levels with the risk of new-onset diabetes . Medicine (Baltimore). 2015;94(7):e563. Gomez-Gomez Y, Organista-Nava J, Villanueva-Flores F, et al. Association Between the 5,10-MTHFR 677C>T and RFC1 80G>A Polymorphisms and Acute Lymphoblastic Leukemia . Arch Med Res. 2019;50(4):175-80. Guo XP, Wang Y, Zhao H, et al. Association of MTHFR C677T polymorphisms and colorectal cancer risk in Asians: evidence of 12,255 subjects . Clin Transl Oncol. 2014;16(7):623-9. Jakubowska A, Rozkrut D, Antoniou A, et al. Association of PHB 1630 C>T and MTHFR 677 C>T polymorphisms with breast and ovarian cancer risk in BRCA1/2 mutation carriers: results from a multicenter study . Br J Cancer. 2012;106(12):2016-24. Sibani S, Christensen B, O'Ferrall E, et al. Characterization of six novel mutations in the methylenetetrahydrofolate reductase (MTHFR) gene in patients with homocystinuria . Hum Mutat. 2000;15(3):280-7. Frosst P, Blom HJ, Milos R, et al. A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase . Nat Genet. 1995;10(1):111-3. Gueant JL, Namour F, Gueant-Rodriguez RM, et al. Folate and fetal programming: a play in epigenomics? Trends Endocrinol Metab. 2013;24(6):279-89. Kumar KA, Lalitha A, Pavithra D, et al. Maternal dietary folate and/or vitamin B12 restrictions alter body composition (adiposity) and lipid metabolism in Wistar rat offspring . J Nutr Biochem. 2013;24(1):25-31. Mfady DS, Sadiq MF, Khabour OF, et al. Associations of variants in MTHFR and MTRR genes with male infertility in the Jordanian population . Gene. 2014;536(1):40-4. Enciso M, Sarasa J, Xanthopoulou L, et al. Polymorphisms in the MTHFR gene influence embryo viability and the incidence of aneuploidy . Hum Genet. 2016;135(5):555-68. Zhu Y, Wu T, Ye L, et al. Prevalent genotypes of methylenetetrahydrofolate reductase (MTHFR) in recurrent miscarriage and recurrent implantation failure . J Assist Reprod Genet. 2018;35(8):1437-42. Rah H, Jeon YJ, Choi Y, et al. Association of methylenetetrahydrofolate reductase (MTHFR 677C>T) and thymidylate synthase (TSER and TS 1494del6) polymorphisms with premature ovarian failure in Korean women . Menopause. 2012;19(11):1260-6. Hwang IW, Kang YD, Kwon BN, et al. Genetic variations of MTHFR gene and their association with preterm birth in Korean women . Medicina (Kaunas). 2017;53(6):380-5. D'Elia PQ, dos Santos AA, Bianco B, et al. MTHFR polymorphisms C677T and A1298C and associations with IVF outcomes in Brazilian women . Reprod Biomed Online. 2014;28(6):733-8. Dobson AT, Davis RM, Rosen MP, et al. Methylenetetrahydrofolate reductase C677T and A1298C variants do not affect ongoing pregnancy rates following IVF . Hum Reprod. 2007;22(2):450-6. Laanpere M, Altmae S, Kaart T, et al. Folate-metabolizing gene variants and pregnancy outcome of IVF . Reprod Biomed Online. 2011;22(6):603-14. Pavlik R, Hecht S, Ochsenkuhn R, et al. Divergent effects of the 677C>T mutation of the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene on ovarian responsiveness and anti-Mullerian hormone concentrations . Fertil Steril. 2011;95(7):2257-62. Huang WJ, Lu XL, Li JT, et al. Effects of folic acid on oligozoospermia with MTHFR polymorphisms in term of seminal parameters, DNA fragmentation, and live birth rate: a double-blind, randomized, placebo-controlled trial . Andrology. 2020;8(1):110-6. Murto T, Kallak TK, Hoas A, et al. Folic acid supplementation and methylenetetrahydrofolate reductase (MTHFR) gene variations in relation to in vitro fertilization pregnancy outcome . Acta Obstet Gynecol Scand. 2015;94(1):65-71. Tables Table 1 Baseline characteristics of included women. Parameters MTHFR 677CC (n=541) MTHFR 677CT (n=585) MTHFR 677TT (n=139) P -value Maternal age (mean±SD, year） 30.54±4.88 30.68±4.93 30.76±4.63 0.84 BMI (mean±SD, kg/m 2 ) 21.46±1.82 21.41±1.90 21.44±1.86 0.93 Duration of infertility (median/IQR, year) 3 /2-5 3 /2-5 4 /2-5 0.40 Type of infertility (n/%) 0.86 Primary infertility 250/46.2 267/45.6 67/48.2 Secondary infertility 291/53.8 318/54.4 72/51.8 ART indication (n/%) 0.11 Male factor 65/12.0 41/7.0 14/10.1 Tubal factor 386/71.3 460/78.6 105/75.5 PCOS 52/9.6 54/9.2 10/7.2 DOR 13/2.4 8/1.4 4/2.9 Endometriosis 25/4.6 22/3.8 6/4.3 Miscarriage History (n/%) 0.72 0 473/87.4 511/87.4 125/89.9 1 54/10.0 58/9.9 9/6.5 ≥2 14/2.6 16/2.7 5/3.6 AMH (mean±SD, ng/ml) 5.01±3.29 5.16±3.54 4.77±3.43 0.45 AFC (mean±SD) 12.84±6.11 12.94±5.82 12.83±6.11 0.95 Fertilization method (n/%) 0.16 IVF 368/68.0 431/73.7 93/66.9 ICSI 126/23.3 107/18.3 30/21.6 IVF + Rescue ICSI 47/8.7 47/8.0 16/11.5 Stimulation protocol (n/%) 0.27 GnRHa long 309/57.1 361/61.7 89/64 GnRHa short 203/37.5 199/34.0 41/29.5 GnRHa ultra-long 29/564.0 41/29.5 9/6.5 Starting does of Gn (mean±SD, IU) 165.78±50.89 166.24±50.99 164.97±52.75 0.96 Days of stimulation (mean±SD, day) 10.59±2.56 10.54±2.36 10.46±2.29 0.85 Total dose of Gn (mean±SD, IU) 1967.20±716.25 1952.97±677.84 1916.25±724.35 0.74 Endometrial thickness (mean±SD, mm) 10.59±2.16 10.73±2.10 10.67±2.24 0.57 Endometrial pattern (n/%) 0.67 A 239/44.2 260/44.4 67/48.2 B 278/51.4 290/49.6 66/47.5 C 24/4.4 35/6.0 6/4.3 E 2 level at hCG Day (mean±SD, pg/ml) 1948.44±1566.37 3066.93±1718.74 3006.04±1730.38 0.49 LH level at hCG Day (mean±SD, mIU/ml) 1.98±1.53 2.02±1.49 1.98±1.32 0.86 P4 level at hCG Day (mean±SD, ng/ml) 0.82±0.34 0.80±0.35 0.81±0.35 0.49 No. of transferred embryos (mean±SD) 1.91±0.29 1.92±0.28 1.91±0.28 0.92 Note: MTHFR = 5,10-methylenetetrahydrofolate reductase, BMI = body mass index, SD = standard deviation, IQR = interquartile range, PCOS = polycystic ovarian syndrome, DOR = diminished ovarian reserve, AMH = anti mullerian hormone, AFC = antral follicle count, IVF = in-vitro fertilization, ICSI = intracytoplasmic sperm injection, Gn = gonadotrophin, No. = number, E2 = estradiol, LH = luteinizing hormone, P4 = progesterone, hCG = human chorionic gonadotrophin. Table 2 Laboratory outcomes and clinical outcomes among the three genotypes of MTHFR C677T polymorphism. Laboratory Outcomes MTHFR 677CC (n=541) MTHFR 677CT (n=585) MTHFR 677TT (n=139) P-value Oocyte obtained (mean±SD) 10.27±4.44 10.23±4.30 9.76±4.05 0.45 No. of 2PNs (mean±SD) 6.47±3.27 6.41±3.30 5.99±3.48 0.30 No. of available embryos (mean±SD) 4.20±2.54 4.18±2.47 3.86±2.52 0.34 No. of good embryos (mean±SD) 3.69±2.44 3.71±2.39 3.34±2.13 0.23 Clinical Outcomes Implantation rate (n/%) 371/35.9 405/36.1 99/37.2 0.92 Chemical pregnancy rate (n/%) 323/59.7 350/59.8 84/60.4 0.99 Clinical pregnancy rate (n/%) 276/51.0 301/51.6 73/52.5 0.95 Preclinical pregnancy loss rate(n/%) 48/8.9 48/8.2 11/7.9 0.90 Miscarriage rate (n/%) 31/5.7 28/4.8 10/7.2 0.50 Live birth rate (n/%) 236/43.6% 262/44.8 56/40.3 0.63 Cumulative live birth rate (n/%) 296/54.7 313/53.5 72/51.8 0.81 Note: MTHFR = 5,10-methylenetetrahydrofolate reductase, PN = pronucleus, SD = standard deviation. Table 3 Odds ratios for association of live birth and MTHFR genotype. MTHFR C677T genotype No. of live births, n Live birth rate, % OR (95% CI) Model 1 * Model 2 & Model 3 § CC 236 43.6 Ref. Ref. Ref. CT 262 44.8 1.15 (0.79-1.68) 1.13 (0.77-1.67) 1.20 (0.81-1.77) TT 56 40.3 1.20 (0.83-1.75) 1.20 (0.82-1.76) 1.23 (0.83-1.80) P -value for trend 0.63 0.63 0.59 Note: MTHFR = 5,10-methylenetetrahydrofolate reductase, CI = confidence interval, OR = odds ratio, Ref. = reference. * Unadjusted & Adjusted for age and BMI § Adjusted for age, BMI, stimulation protocol, ART indication, miscarriage history, endometrial thickness, and infertility type. Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. 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Also discoverable on Platform About Our Team In Review Editorial Policies Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-13278","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Research","associatedPublications":[],"authors":[{"id":331496,"identity":"b44c1332-1002-4ddf-b546-41b336cf17e4","order_by":1,"name":"Hong Zeng","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAA3ElEQVRIiWNgGAWjYDACZgaGAyDaAER8MLCRI00L44yCNGPibQNpYeb5cDiRoErddt6DB39U3LHbzt57+LWNAXMCA/vhoxvwaTE7zJdwQOLMs+SdPefSrHMM2PIYeNLSbuDXwmNwwLDtcLLBjRwz4xwDnmIGCR4zwloS/0G1WBhIJDYQpeVgw2E7oBbjxwwGBsRpOdhw7HCCwZkzZow9BgnGbAT9cv6M8ccfNYftDY73GH/48ee/HD/74WN4tcBAYgMDA5sEiMVGjHIQsAdi5g/Eqh4Fo2AUjIKRBQA2sE8/xZUo0wAAAABJRU5ErkJggg==","orcid":"https://orcid.org/0000-0003-0216-8117","institution":"Xiangya Hospital Central South University","correspondingAuthor":true,"submittingAuthor":false,"prefix":"","firstName":"Hong","middleName":"","lastName":"Zeng","suffix":""},{"id":331497,"identity":"223f9bb1-7efe-40f9-b158-148dc9bd2d1d","order_by":2,"name":"Hebin Xie","email":"","orcid":"","institution":"Changsha Central Hospital of Nanhua University","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Hebin","middleName":"","lastName":"Xie","suffix":""},{"id":331498,"identity":"151e96af-b0ca-445a-a05a-8bb2b40413f4","order_by":3,"name":"Dongmei He","email":"","orcid":"","institution":"Sun Yat-Sen University Second University Hospital","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Dongmei","middleName":"","lastName":"He","suffix":""},{"id":331499,"identity":"cefbd1d4-50e4-44e3-82bb-7d24bc3d7548","order_by":4,"name":"Yuhao Zhao","email":"","orcid":"","institution":"Xiangya Hospital of Central South University","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Yuhao","middleName":"","lastName":"Zhao","suffix":""},{"id":331500,"identity":"d96eeaad-8295-48c1-9b85-de7e4ef0af6d","order_by":5,"name":"Nenghui Liu","email":"","orcid":"","institution":"Xiangya Hospital of Central South University","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Nenghui","middleName":"","lastName":"Liu","suffix":""}],"badges":[],"createdAt":"2020-02-04 15:05:12","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.2.22704/v1","doiUrl":"https://doi.org/10.21203/rs.2.22704/v1","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":454619,"identity":"86449f9a-64bc-42a2-ba82-a763ad76705b","added_by":"auto","created_at":"2020-02-05 22:15:46","extension":"tif","order_by":2,"title":"Figure 2","display":"","copyAsset":false,"role":"figure","size":578587,"visible":true,"origin":"","legend":"Chart","description":"","filename":"Fig1.tif","url":"https://assets-eu.researchsquare.com/files/68d1f7ac-d2eb-4203-9f5b-66c2c17e9b14/v1/Fig 1.tif"},{"id":13488014,"identity":"790d3cf8-07f4-47e3-827d-a464c7a5899c","added_by":"auto","created_at":"2021-09-16 22:13:01","extension":"pdf","order_by":0,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":1587374,"visible":true,"origin":"","legend":"","description":"","filename":"manuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-13278/v1/b1c9b8b8-0bd1-4c47-adf4-1ebd05edceb9.pdf"}],"financialInterests":"","formattedTitle":"Maternal MTHFR C677T polymorphism does not affect live birth rate following IVF in Chinese Han population: a retrospective cohort study of 1265 women","fulltext":[{"header":"Background","content":" \u003cp\u003e5,10-methylenetetrahydrofolate reductase (MTHFR) is a key enzyme for folic acid.\u003c/p\u003e \u003cp\u003eMTHFR catalyzes 5,10-methylenetetrahydrofolate to 5-methylenetetrahydrofolate, the latter is the predominant circulating form of folate, which is essential for the synthesis of nucleotide and S-adenosylmethionine, the re-methylation of homocysteine (hcy) to methionine, the methylation of DNA, proteins, neurotransmitters and phospholipids [\u003cspan citationid=\"CR1\" class=\"CitationRef\"\u003e1\u003c/span\u003e, \u003cspan citationid=\"CR2\" class=\"CitationRef\"\u003e2\u003c/span\u003e]. There are implications that a wide range of diseases (thrombophic disease, ischemic stroke, diabetes, leukemia, colorectal cancer, breast cancer, ovarian cancer, and so on) are related with \u003cspan type=\"Italic\" class=\"Italic\" name=\"Emphasis\"\u003eMTHFR\u003c/span\u003e polymorphisms [\u003cspan additionalcitationids=\"CR4 CR5 CR6\" citationid=\"CR3\" class=\"CitationRef\"\u003e3\u003c/span\u003e\u0026ndash;\u003cspan citationid=\"CR7\" class=\"CitationRef\"\u003e7\u003c/span\u003e]. More than 20 polymorphisms of \u003cspan type=\"Italic\" class=\"Italic\" name=\"Emphasis\"\u003eMTHFR\u003c/span\u003e have been described [\u003cspan citationid=\"CR8\" class=\"CitationRef\"\u003e8\u003c/span\u003e]. \u003cspan type=\"Italic\" class=\"Italic\" name=\"Emphasis\"\u003eMTHFR\u003c/span\u003e C677T (rs1801133) is one of the most investigated polymorphisms. The \u003cspan type=\"Italic\" class=\"Italic\" name=\"Emphasis\"\u003eMTHFR\u003c/span\u003e 677C\u0026thinsp;\u0026gt;\u0026thinsp;T transition causes an alanine to valine replacement (Ala222Val) in the catalytic domain of MTHFR, which leads to reduced MTHFR activity,\u003cspan type=\"Italic\" class=\"Italic\" name=\"Emphasis\"\u003eMTHFR\u003c/span\u003e 677CT and \u003cspan type=\"Italic\" class=\"Italic\" name=\"Emphasis\"\u003eMTHFR\u003c/span\u003e 677TT have in vitro MTHFR activity reduced by about 70% and 35%, respectively [\u003cspan citationid=\"CR9\" class=\"CitationRef\"\u003e9\u003c/span\u003e]. Reduced MTHFR activity has a negative effect on reproductive functions as oocyte and embryo development, endometrial receptivity, embryo implantation, and the maintenance of pregnancy [\u003cspan citationid=\"CR10\" class=\"CitationRef\"\u003e10\u003c/span\u003e, \u003cspan citationid=\"CR11\" class=\"CitationRef\"\u003e11\u003c/span\u003e]. Evidences showed that \u003cspan type=\"Italic\" class=\"Italic\" name=\"Emphasis\"\u003eMTHFR\u003c/span\u003e 677C\u0026thinsp;\u0026gt;\u0026thinsp;T is associated with ovarian reserve, implantation failure, pregnancy loss, human subfertility and infertility, oocyte maturation, embryo aneuploid [\u003cspan additionalcitationids=\"CR13\" citationid=\"CR12\" class=\"CitationRef\"\u003e12\u003c/span\u003e\u0026ndash;\u003cspan citationid=\"CR14\" class=\"CitationRef\"\u003e14\u003c/span\u003e], \u003cspan type=\"Italic\" class=\"Italic\" name=\"Emphasis\"\u003eMTHFR\u003c/span\u003e 677C\u0026thinsp;\u0026gt;\u0026thinsp;T mutation is also risk factor for premature ovarian failure [\u003cspan citationid=\"CR15\" class=\"CitationRef\"\u003e15\u003c/span\u003e], recurrent miscarriage and implantation failures [\u003cspan citationid=\"CR14\" class=\"CitationRef\"\u003e14\u003c/span\u003e] preterm birth [\u003cspan citationid=\"CR16\" class=\"CitationRef\"\u003e16\u003c/span\u003e]. However, the role of \u003cspan type=\"Italic\" class=\"Italic\" name=\"Emphasis\"\u003eMTHFR\u003c/span\u003e C677T genotype on ART outcomes remained unclear. Despite that several studies evaluated the relationship of \u003cspan type=\"Italic\" class=\"Italic\" name=\"Emphasis\"\u003eMTHFR\u003c/span\u003e C677T polymorphism and pregnancy outcome following IVF [\u003cspan additionalcitationids=\"CR18\" citationid=\"CR17\" class=\"CitationRef\"\u003e17\u003c/span\u003e\u0026ndash;\u003cspan citationid=\"CR19\" class=\"CitationRef\"\u003e19\u003c/span\u003e], the results remained controversial. Besides, most of the studies included a small sample size, and no studies reported outcome of live birth rate. Therefore more definitive data with larger sample size and long-term ART outcomes are needed to evaluate whether \u003cspan type=\"Italic\" class=\"Italic\" name=\"Emphasis\"\u003eMTHFR\u003c/span\u003e C677T polymorphism affect ART outcomes. In this study, we evaluate the relationship of \u003cspan type=\"Italic\" class=\"Italic\" name=\"Emphasis\"\u003eMTHFR\u003c/span\u003e C677T polymorphism with live birth rate and the cumulative live birth. To evaluate the relationship of \u003cspan type=\"Italic\" class=\"Italic\" name=\"Emphasis\"\u003eMTHFR\u003c/span\u003e C677T polymorphism and live birth, the logistic regression analysis was performed using both unadjusted model and 2 models adjusted by different confounding factors.\u003c/p\u003e "},{"header":"Materials And Methods","content":"\u003cp\u003eThis was a retrospective cohort study of women undergoing their first in-vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) and fresh embryo transfer (ET) cycle at Reproductive Medicine Center of Xiangya Hospital from 2015 to 2017. Data were collected through the electronic records. This study was approved by the Ethics committee of Xiangya Hospital. The study population was divided into three groups based on the results of \u003cem\u003eMTHFR\u003c/em\u003e C677T genotyping (\u003cem\u003eMTHFR\u003c/em\u003e 677CC, \u003cem\u003eMTHFR\u003c/em\u003e 677CT, and \u003cem\u003eMTHFR\u003c/em\u003e 677TT).\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eInclusion criteria\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eWomen undergoing their first IVF/ICIS and fresh ET cycle; The couple are Chinese Han nationality; 1~2 good embryos transferred to the patients at Day 3; 18 kg/m\u003csup\u003e2\u003c/sup\u003e \u0026le; BM I\u0026le; 25 kg/m\u003csup\u003e2\u003c/sup\u003e; Maternal age \u0026le; 45 years.\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eExclusion criteria\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eAbnormal karyotype in any of the couple. Thyroid dysfunction. Severe Hydrosalpinx. Intrauterine adhesions. Myoma\u0026gt;5cm. Donor cycles.\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eART procedure\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eControlled ovarian stimulation (COS) was performed using recombinant FSH (rFSH) with or without human Menopausal Gonadotrophin (HMG), or urinary FSH (uFSH) with or without HMG, under pituitary suppression by Gonadotrophin releasing hormone analogue (GnRHa). The choice of starting gonadotrophin (Gn) was based on maternal age, BMI, Basal FSH concentration, AMH concentration, then Gn dose can be adjusted according to patients\u0026rsquo; response during COS. The COS protocol was decided according to the physicians\u0026rsquo; clinical experience and ART indications. For GnRHa long protocol, Triptorelin (Diphereline, France; 0.25mg/d subcutaneous injection) starting from the middle luteal phase of the previous cycle. After two weeks, pituitary suppression was verified (follicular diameter \u0026lt; 5 mm, endometrial thickness \u0026lt; 5 mm, serum estradiol \u0026lt; 50 pg/mL, serum FSH \u0026lt; 5 IU/L, serum LH \u0026lt; 5 IU/L) before starting COS. For GnRHa short protocol, Triptorelin was started at a subcutaneous dose of 0.25mg/d at Day 2, COS was started at Day 3. For ultra-long protocol, the first injection of Leuprorelin (Livzon Corp., Shanghai, China, 3.75mg, subcutaneously) was given to patients, 4 weeks later, the second Leuprorelin (, 3.75mg, subcutaneously) was given, 3-4 weeks later, COS was started if down-regulation was satisfied. Follicular development was monitored by transvaginal ultrasound and serum estradiol (E2). Measurements performed every 2-3 days from stimulation day 5-6. Ovulation was triggered by injecting 10,000 international units (IU) of hCG (Livzon Corp., Shanghai, China) intramuscularly when at least 1 follicle reached 18 mm, or at least 3 follicles reached 16 mm. After 36 hours of hCG injection, ultrasound guided transvaginal oocyte aspiration (OPU) was performed. Luteal phase support was performed at the day of OPU. Embryos were transferred at Day 3. All the patients were supplemented with 800 mg folic acid from embryo transfer (ET) day to 12 gestational weeks if pregnancy is established.\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eSample collection and MTHFR C677T genotyping\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003ePeripheral blood was collected from every women before ART treatment. Genomic DNA was extracted from blood using the QIAamp DNA Blood Mini Kit (Qiagen, Hilden, Germany). Reverse transcription-polymerase chain reaction (RT-PCR) was used to determine the genotype of MTHFR C677T.\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eStatistical analysis\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe categorical variables were presented as frequencies and percentages, the continuous variables were presented as means and standard deviations (SDs) or interquartile ranges (IQRs) depending on whether the data distribution was normal. . We compared categorical variables between groups using \u0026chi;\u003csup\u003e2\u003c/sup\u003e testing, and we compared continuous variables using analysis of variance (ANOVA) or the Kruskal-Wallis test according to distribution type. We evaluated the relationship of \u003cem\u003eMTHFR\u003c/em\u003e 677 genotype and live birth using logistic regression model with and without adjusting the confounding factors that may have expected influence on our outcome. We used 3 models in total, including model 1, unadjusted; model 2, adjusted for age and BMI, for model 3, adjusted model 2 for infertility type, stimulation protocol, ART indication, miscarriage history, and endometrial thickness. \u0026nbsp;\u003c/p\u003e\n\u003cp\u003eAll statistical analyses were 2-sided, and we considered a \u003cem\u003ep\u003c/em\u003e-value of less than 0.05 to be statistically significant. The statistical analyses were performed by SPSS (version 25, Chicago, USA). Hardy-Weinberg equilibrium (HWE) was examined using the StataSE software (version 15.0, Stata Corp., USA). Deviation from HWE was confirmed if \u003cem\u003ep\u003c/em\u003e-value \u0026lt; 0.05.\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eOutcomes and definitions\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe primary outcomes were live birth rate, and cumulative live birth rate per stimulation cycle. The secondary outcomes including laboratory outcomes ( number of oocytes, number of 2PNs, number of available embryos, number of good embryos) and clinical outcomes (chemical pregnancy rate, clinical pregnancy rate, implantation rate, preclinical pregnancy loss rate, miscarriage rate).\u003c/p\u003e\n\u003cp\u003eChemical pregnancy cases were defined as increased serum HCG levels (\u0026gt;10 IU/L) at 12 days after embryo transfer. clinical pregnancy was confirmed by ultrasonographic visualization of gestational sacs 4\u0026ndash;5 weeks after embryo transfer. Implantation rate was calculated as the gestational sac number divided by the transferred embryos number. We defined preclinical pregnancy loss as cases who was chemical pregnancy but not reached clinical pregnancy. Miscarriage was defined as spontaneous clinical pregnancy loss before 24 gestational weeks. Live birth was defined as birth of at least one newborn after 24 weeks\u0026rsquo; gestation that exhibits any sign of life. We also reported the cumulative live birth a stimulation cycle at 24 months after their first oocyte retrieve cycle.\u003c/p\u003e"},{"header":"Results","content":"\u003cp\u003eOf the initial cohort of 1756 women, the following patients were excluded: cycle cancelled (n=23), all embryos cryopreserved (n=79), Abnormal karyotype (n=19), Not Chinese Han population (n=34), Thyroid dysfunction (n=75), Severe Hydrosalpinx (n=21), Intrauterine adhesion (n=47), Myoma\u0026gt;5cm (n=26), BMI\u0026lt;18kg/m\u003csup\u003e2\u003c/sup\u003e or BMI \u0026gt;25 kg/m\u003csup\u003e2\u003c/sup\u003e (n=51), Maternal age\u0026gt;45 years (n=38), Embryos not transferred at D3 (n=43), Loss to follow-up (n=12), incomplete data (n=23). After all exclusion, a total of 1265 women remained. Based on the results of \u003cem\u003eMTHFR\u003c/em\u003e C677T genotyping, 541 women were included in \u003cem\u003eMTHFR\u003c/em\u003e 677CC group, 585 women were included in \u003cem\u003eMTHFR\u003c/em\u003e 677CT group, 139 women were included in \u003cem\u003eMTHFR\u003c/em\u003e 677TT groups (Fig 1). There was no deviation from HWE in this cohort population (\u003cem\u003ep\u003c/em\u003e-value = 0.31).\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eBaseline characteristics\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eBaseline parameters including maternal age, BMI, duration of infertility, type of infertility, ART indication, miscarriage history, serum AMH, AFC, fertilization method, stimulation protocol, starting Gn does, total Gn does, days of stimulation, endometrial thickness, endometrial pattern, estradiol level at hCG day, LH level at hCG day, progesterone level at hCG day, number of transferred embryos. All the baseline parameters were not significantly different between the three groups (Table 1).\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eLive birth rate and cumulative live birth rate. \u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe live birth rate per fresh ET cycle was 43.6%, 44.8%, and 40.3% in \u003cem\u003eMTHFR\u003c/em\u003e 677CC group, \u003cem\u003eMTHFR\u003c/em\u003e 677CT group, and \u003cem\u003eMTHFR\u003c/em\u003e 677TT group respectively, without significant difference (\u003cem\u003ep\u003c/em\u003e-value = 0.63) (Table 2). The cumulative live birth rate per stimulation cycle was 54.7%, 53.5%, and 51.8% respectively, without significant difference (\u003cem\u003ep\u003c/em\u003e-value =0.81) (Table 2).\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eSecondary laboratory and clinical outcomes\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe secondary laboratory outcomes including number of oocytes obtained, number of 2PNs, number of available embryos, number of good embryos. All the laboratory outcomes were not significantly different between the three groups (Table 2). The secondary clinical outcomes including implantation rate, chemical pregnancy rate, clinical pregnancy rate, preclinical pregnancy loss rate, miscarriage rate. All the clinical outcomes were not significantly different between the three groups (Table 2) .\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAssociation of \u003cem\u003eMTHFR\u003c/em\u003e C677T genotype and live birth\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe logistical regression analyses showed no significant association of \u003cem\u003eMTHFR\u003c/em\u003e C677T genotype with live birth whether under unadjusted model 1 (\u003cem\u003ep\u003c/em\u003e-value for trend = 0.63; CT: OR 1.15, 95%CI 0.79-1.68; TT: OR 1.20, 95%CI 0.83-1.75), model 2 adjusted by maternal age, BMI (\u003cem\u003ep\u003c/em\u003e-value for trend = 0.63, CT: OR 1.13, 95%CI 0.77-1.67; TT: OR 1.20; 95%CI 0.82-1.76), or model 3 adjusted by maternal age and BMI, and model 2 which adjusted by maternal age, BMI, infertility type, stimulation protocol, ART indication, miscarriage history, and endometrial thickness (\u003cem\u003ep\u003c/em\u003e-value for trend = 0.59; CT: OR 1.20, 95%CI 0.81-1.77; TT: OR 1.23, 95%CI 0.83-1.80) (Table 3).\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e"},{"header":"Discussion","content":" \u003cp\u003e \u003cspan type=\"Italic\" class=\"Italic\" name=\"Emphasis\"\u003eMTHFR\u003c/span\u003e is a pivotal gene for folate metabolism and is essential for human reproduction. Previous evidences showed that variants in \u003cspan type=\"Italic\" class=\"Italic\" name=\"Emphasis\"\u003eMTHFR\u003c/span\u003e C677T modify the serum concentrations of folate and homocysteine, and may affect IVF outcomes. However, the results remained quite conflicting. Several studies reported a negative effect of \u003cspan type=\"Italic\" class=\"Italic\" name=\"Emphasis\"\u003eMTHFR\u003c/span\u003e 677TT genotype on ART outcomes. Laanpere et al. reported that \u003cspan type=\"Italic\" class=\"Italic\" name=\"Emphasis\"\u003eMTHFR\u003c/span\u003e 677TT individuals had a lower proportion of good-quality embryos and a decreased chance of pregnancy [\u003cspan citationid=\"CR19\" class=\"CitationRef\"\u003e19\u003c/span\u003e]. Enciso et al. found that patients with \u003cspan type=\"Italic\" class=\"Italic\" name=\"Emphasis\"\u003eMTHFR\u003c/span\u003e 677C\u0026thinsp;\u0026gt;\u0026thinsp;T variant showed a higher rate of aneuploid embryos and a lower rate of implantation [\u003cspan citationid=\"CR13\" class=\"CitationRef\"\u003e13\u003c/span\u003e], Pavlik et al. observed an association of \u003cspan type=\"Italic\" class=\"Italic\" name=\"Emphasis\"\u003eMTHFR\u003c/span\u003e 677TT genotype with higher serum AMH levels but lower number of oocytes retrieved [\u003cspan citationid=\"CR20\" class=\"CitationRef\"\u003e20\u003c/span\u003e]. However, Delia et al. demonstrated a significant effect of MTHFR C677T polymorphism on oocyte maturity and recovery in Brazilian women,but not affect normal fertilization, good-quality embryo, and clinical pregnancy rate [\u003cspan citationid=\"CR17\" class=\"CitationRef\"\u003e17\u003c/span\u003e]. Dobson et al. found no significant association of \u003cspan type=\"Italic\" class=\"Italic\" name=\"Emphasis\"\u003eMTHFR\u003c/span\u003e C677T polymorphism with number of embryos, quality of embryos, and ongoing pregnancy rate [\u003cspan citationid=\"CR18\" class=\"CitationRef\"\u003e18\u003c/span\u003e]. Results of our study showed that maternal \u003cspan type=\"Italic\" class=\"Italic\" name=\"Emphasis\"\u003eMTHFR\u003c/span\u003e C677T genotype does not affect live birth rate, cumulative live birth rate per stimulation cycle, and other ART outcomes including laboratory outcomes (number of oocytes, number of 2PNs, number of available embryos, number of good embryos) and clinical outcomes (chemical pregnancy rate, clinical pregnancy rate, implantation rate, preclinical pregnancy loss rate, miscarriage rate) in Chinese Han couples following their first IVF-ET cycle, indicating that maternal \u003cspan type=\"Italic\" class=\"Italic\" name=\"Emphasis\"\u003eMTHFR\u003c/span\u003e C677T genotype does predict ART outcomes in Chinese Han couple. Huang et al. in 2019 conducted a randomized trials on folic acid supplementation in oligozoospermic men with \u003cspan type=\"Italic\" class=\"Italic\" name=\"Emphasis\"\u003eMTHFR\u003c/span\u003e 677 TT genotype, they found that 3 months\u0026rsquo; supplementation of folic acid significantly decreased the seminal MDA and sperm DNA fragmentation index (DFI), and increased spontaneous pregnancy rate and live birth rate, but folic acid supplementation did not exhibit any advantage in \u003cspan type=\"Italic\" class=\"Italic\" name=\"Emphasis\"\u003eMTHFR\u003c/span\u003e 677CT genotype [\u003cspan citationid=\"CR21\" class=\"CitationRef\"\u003e21\u003c/span\u003e]. An explanation of our negative results is that, all the included women were regularly supplemented with 800\u0026nbsp;mg folic acid at the day of embryo transfer, if establishment of pregnancy is confirmed, the folic acid supplementation lasted for 3\u0026nbsp;months. Maybe it is the supplementation of folic acid increased the ART outcomes and then make the difference disappear. However, Murto et al. found that folic acid intake or folate status did not affect serum Hcy level and ART outcomes including chemical pregnancy, clinical pregnancy, miscarriage and livebirth [\u003cspan citationid=\"CR22\" class=\"CitationRef\"\u003e22\u003c/span\u003e]. In spite of this, maternal \u003cspan type=\"Italic\" class=\"Italic\" name=\"Emphasis\"\u003eMTHFR\u003c/span\u003e C677T genotype is not recommended for Chinese Han population undergoing their first IVF-ET cycle and supplemented with 800\u0026nbsp;mg folic acid. Why our results are different from the others can be elucidated as following: (1) The effect of different ethnicity and nationality, for ethnicity and nationality may significantly affect genetic susceptibility. (2) Different inclusion and exclusion criteria. Our study exclude the high-risk factors that affect ART outcomes. (3) Adjusting for confounding factors. Some studies did not adjust the confounding factors, or only adjust limited factors. While our study evaluate the association of \u003cspan type=\"Italic\" class=\"Italic\" name=\"Emphasis\"\u003eMTHFR\u003c/span\u003e C677T genotype with live birth by 3 model, including model 1 (unadjusted), model 2 (adjusted for age and BMI), and model 3 (adjusted model 2 for infertility type, stimulation protocol, ART indication, miscarriage history, and endometrial thickness). The results of the three models are in consistent. (4) Sample size. Our study consist of 1265 patients, the sample size is so far the largest. However, most of the previous studies consist of small sample size. Besides, our study has the following strengths: The completeness of case data and the long-term follow-up, we have a minimum follow-up of 2\u0026nbsp;years and maximum of 5\u0026nbsp;years after the patients\u0026rsquo; first IVF cycle, the endpoint of live birth tracked down until the embryo used up after first IVF cycle. As far as we know, this is the first article that evaluate the association of maternal \u003cspan type=\"Italic\" class=\"Italic\" name=\"Emphasis\"\u003eMTHFR\u003c/span\u003e C677T genotype with live birth and cumulative live birth following IVF. However, there are some limitations in the study: (1) The biggest limitation of this study is its retrospective nature. However, our inclusion and exclusion are very rigorous to control the influence of risk factors, and we perform a robust statistical analysis to control other confounding factors. Besides, the completeness of patents\u0026rsquo; information is satisfied and the follow-up term is long. Therefore, the results from this study should not be significantly affected. (2) The effect of male partner\u0026rsquo;s \u003cspan type=\"Italic\" class=\"Italic\" name=\"Emphasis\"\u003eMTHFR\u003c/span\u003e C677T polymorphism was not considered; (3) The combination effect of haplotype of different \u003cspan type=\"Italic\" class=\"Italic\" name=\"Emphasis\"\u003eMTHFR\u003c/span\u003e polymorphisms was not considered. (4) the combination effect of other genetic polymorphisms in the pathway of folic acid metabolism was not considered. (5) Serum folate and homocysteine levels were not detected. Further studies are needed to evaluate the role of male partner\u0026rsquo;s \u003cspan type=\"Italic\" class=\"Italic\" name=\"Emphasis\"\u003eMTHFR\u003c/span\u003e genotype, the combination role of different genetic polymorphisms in the pathway of folic acid metabolism, and the interaction of serum vitamin B12, folate, hcy with MTHFR genotypes on ART outcomes, as well as on pregnancy complication of preeclampsia, and perinatal outcomes.\u003c/p\u003e "},{"header":"Conclusions","content":" \u003cp\u003eMaternal \u003cspan type=\"Italic\" class=\"Italic\" name=\"Emphasis\"\u003eMTHFR\u003c/span\u003e C677T genotyping alone does not significantly affect live birth rate and cumulative live birth rate following first IVF-ET cycle in Chinese Han couples. We should be very cautious to extrapolate the results to other ethnicity populations, and we can\u0026rsquo;t extrapolate the results to patients who did no supplemented with folic acid.\u003c/p\u003e "},{"header":"Abbreviations","content":" \u003cdiv class=\"DefinitionList\"\u003e \u003cdiv class=\"DefinitionListEntry\"\u003e \u003cdiv class=\"Term\"\u003eMTHFR\u003c/div\u003e \u003cdiv class=\"Description\"\u003e \u003cp\u003e5,10-methylenetetrahydrofolate reductase, IVF\u0026thinsp;=\u0026thinsp;in-vitro fertilization, ICSI\u0026thinsp;=\u0026thinsp;intracytoplasmic sperm injection, ET\u0026thinsp;=\u0026thinsp;embryo transfer, ART\u0026thinsp;=\u0026thinsp;assisted reproduction technology,\u003c/p\u003e \u003c/div\u003e \u003c/div\u003e \u003c/div\u003e "},{"header":"Declarations","content":"\u003cp\u003e\u003cstrong\u003eEthics approval and consent to participate:\u003c/strong\u003e The study is approved by the Ethics Committee of Xiangya Hospital. This is a retrospective analysis, and no consent was signed by the patients.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAvailability of data and materials: \u003c/strong\u003eThe data sets used and/or analyzed during the current study are available from the corresponding author on reasonable request.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eConsent for publication: \u003c/strong\u003eNot applicable\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eCompeting interests: \u003c/strong\u003eThe authors declare they have no competing interests\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eFunding:\u003c/strong\u003e This study was funded by the National Natural Science Foundation of China (http://www.nsfc.gov.cn/) (grant number 81571441).\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAuthor\u0026rsquo;s contributions:\u003c/strong\u003e Zeng. designed the study, draft the manuscript, tables and figures; Xie. performed the statistical analyses; He. and Zhao. Collected the participants\u0026rsquo; information; Liu. designed the study and revised the manuscript.\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e"},{"header":"References","content":"\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003col\u003e\n\u003cli\u003eTurgal M, Gumruk F, Karaagaoglu E, et al. \u003cem\u003eMethylenetetrahydrofolate Reductase Polymorphisms and Pregnancy Outcome\u003c/em\u003e. Geburtshilfe Frauenheilkd. 2018;78(9):871-8.\u003c/li\u003e\n\u003cli\u003eKim SY, Park SY, Choi JW, et al. \u003cem\u003eAssociation between MTHFR 1298A\u0026gt;C polymorphism and spontaneous abortion with fetal chromosomal aneuploidy\u003c/em\u003e. Am J Reprod Immunol. 2011;66(4):252-8.\u003c/li\u003e\n\u003cli\u003eQin X, Spence JD, Li J, et al. \u003cem\u003eInteraction of serum vitamin B12 and folate with MTHFR genotypes on risk of ischemic stroke\u003c/em\u003e. Neurology. 2020.\u003c/li\u003e\n\u003cli\u003eQin X, Li Y, Yuan H, et al. \u003cem\u003eRelationship of MTHFR gene 677C --\u0026gt; T polymorphism, homocysteine, and estimated glomerular filtration rate levels with the risk of new-onset diabetes\u003c/em\u003e. Medicine (Baltimore). 2015;94(7):e563.\u003c/li\u003e\n\u003cli\u003eGomez-Gomez Y, Organista-Nava J, Villanueva-Flores F, et al. \u003cem\u003eAssociation Between the 5,10-MTHFR 677C\u0026gt;T and RFC1 80G\u0026gt;A Polymorphisms and Acute Lymphoblastic Leukemia\u003c/em\u003e. Arch Med Res. 2019;50(4):175-80.\u003c/li\u003e\n\u003cli\u003eGuo XP, Wang Y, Zhao H, et al. \u003cem\u003eAssociation of MTHFR C677T polymorphisms and colorectal cancer risk in Asians: evidence of 12,255 subjects\u003c/em\u003e. Clin Transl Oncol. 2014;16(7):623-9.\u003c/li\u003e\n\u003cli\u003eJakubowska A, Rozkrut D, Antoniou A, et al. \u003cem\u003eAssociation of PHB 1630 C\u0026gt;T and MTHFR 677 C\u0026gt;T polymorphisms with breast and ovarian cancer risk in BRCA1/2 mutation carriers: results from a multicenter study\u003c/em\u003e. Br J Cancer. 2012;106(12):2016-24.\u003c/li\u003e\n\u003cli\u003eSibani S, Christensen B, O'Ferrall E, et al. \u003cem\u003eCharacterization of six novel mutations in the methylenetetrahydrofolate reductase (MTHFR) gene in patients with homocystinuria\u003c/em\u003e. Hum Mutat. 2000;15(3):280-7.\u003c/li\u003e\n\u003cli\u003eFrosst P, Blom HJ, Milos R, et al. \u003cem\u003eA candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase\u003c/em\u003e. Nat Genet. 1995;10(1):111-3.\u003c/li\u003e\n\u003cli\u003eGueant JL, Namour F, Gueant-Rodriguez RM, et al. \u003cem\u003eFolate and fetal programming: a play in epigenomics?\u003c/em\u003e Trends Endocrinol Metab. 2013;24(6):279-89.\u003c/li\u003e\n\u003cli\u003eKumar KA, Lalitha A, Pavithra D, et al. \u003cem\u003eMaternal dietary folate and/or vitamin B12 restrictions alter body composition (adiposity) and lipid metabolism in Wistar rat offspring\u003c/em\u003e. J Nutr Biochem. 2013;24(1):25-31.\u003c/li\u003e\n\u003cli\u003eMfady DS, Sadiq MF, Khabour OF, et al. \u003cem\u003eAssociations of variants in MTHFR and MTRR genes with male infertility in the Jordanian population\u003c/em\u003e. Gene. 2014;536(1):40-4.\u003c/li\u003e\n\u003cli\u003eEnciso M, Sarasa J, Xanthopoulou L, et al. \u003cem\u003ePolymorphisms in the MTHFR gene influence embryo viability and the incidence of aneuploidy\u003c/em\u003e. Hum Genet. 2016;135(5):555-68.\u003c/li\u003e\n\u003cli\u003eZhu Y, Wu T, Ye L, et al. \u003cem\u003ePrevalent genotypes of methylenetetrahydrofolate reductase (MTHFR) in recurrent miscarriage and recurrent implantation failure\u003c/em\u003e. J Assist Reprod Genet. 2018;35(8):1437-42.\u003c/li\u003e\n\u003cli\u003eRah H, Jeon YJ, Choi Y, et al. \u003cem\u003eAssociation of methylenetetrahydrofolate reductase (MTHFR 677C\u0026gt;T) and thymidylate synthase (TSER and TS 1494del6) polymorphisms with premature ovarian failure in Korean women\u003c/em\u003e. Menopause. 2012;19(11):1260-6.\u003c/li\u003e\n\u003cli\u003eHwang IW, Kang YD, Kwon BN, et al. \u003cem\u003eGenetic variations of MTHFR gene and their association with preterm birth in Korean women\u003c/em\u003e. Medicina (Kaunas). 2017;53(6):380-5.\u003c/li\u003e\n\u003cli\u003eD'Elia PQ, dos Santos AA, Bianco B, et al. \u003cem\u003eMTHFR polymorphisms C677T and A1298C and associations with IVF outcomes in Brazilian women\u003c/em\u003e. Reprod Biomed Online. 2014;28(6):733-8.\u003c/li\u003e\n\u003cli\u003eDobson AT, Davis RM, Rosen MP, et al. \u003cem\u003eMethylenetetrahydrofolate reductase C677T and A1298C variants do not affect ongoing pregnancy rates following IVF\u003c/em\u003e. Hum Reprod. 2007;22(2):450-6.\u003c/li\u003e\n\u003cli\u003eLaanpere M, Altmae S, Kaart T, et al. \u003cem\u003eFolate-metabolizing gene variants and pregnancy outcome of IVF\u003c/em\u003e. Reprod Biomed Online. 2011;22(6):603-14.\u003c/li\u003e\n\u003cli\u003ePavlik R, Hecht S, Ochsenkuhn R, et al. \u003cem\u003eDivergent effects of the 677C\u0026gt;T mutation of the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene on ovarian responsiveness and anti-Mullerian hormone concentrations\u003c/em\u003e. Fertil Steril. 2011;95(7):2257-62.\u003c/li\u003e\n\u003cli\u003eHuang WJ, Lu XL, Li JT, et al. \u003cem\u003eEffects of folic acid on oligozoospermia with MTHFR polymorphisms in term of seminal parameters, DNA fragmentation, and live birth rate: a double-blind, randomized, placebo-controlled trial\u003c/em\u003e. Andrology. 2020;8(1):110-6.\u003c/li\u003e\n\u003cli\u003eMurto T, Kallak TK, Hoas A, et al. \u003cem\u003eFolic acid supplementation and methylenetetrahydrofolate reductase (MTHFR) gene variations in relation to in vitro fertilization pregnancy outcome\u003c/em\u003e. Acta Obstet Gynecol Scand. 2015;94(1):65-71.\u003c/li\u003e\n\u003c/ol\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e"},{"header":"Tables","content":"\u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;text-align:justify;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif; color: rgb(0, 0, 0); font-size: 10px;\"\u003eTable 1 Baseline characteristics of included women.\u003c/span\u003e\u003c/p\u003e\n\u003ctable border=\"1\" cellpadding=\"0\" cellspacing=\"0\" style=\"width:510.35pt;margin-left:-42.8pt;border-collapse:collapse;border: none;\" width=\"680\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 205.6pt;border-top: 1pt solid windowtext;border-left: none;border-bottom: 1pt solid windowtext;border-right: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"40.294117647058826%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eParameters\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border-top: 1pt solid windowtext;border-left: none;border-bottom: 1pt solid windowtext;border-right: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"16.61764705882353%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eMTHFR 677CC (n=541)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border-top: 1pt solid windowtext;border-left: none;border-bottom: 1pt solid windowtext;border-right: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"16.61764705882353%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eMTHFR 677CT (n=585)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.9pt;border-top: 1pt solid windowtext;border-left: none;border-bottom: 1pt solid windowtext;border-right: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"16.91176470588235%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eMTHFR 677TT (n=139)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 48.75pt;border-top: 1pt solid windowtext;border-left: none;border-bottom: 1pt solid windowtext;border-right: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"9.558823529411764%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cem\u003eP\u003c/em\u003e-value\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 205.6pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"40.294117647058826%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eMaternal age (mean±SD, year）\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"16.61764705882353%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e30.54±4.88\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"16.61764705882353%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e30.68±4.93\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.9pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"16.91176470588235%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e30.76±4.63\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 48.75pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"9.558823529411764%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.84\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 205.6pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"40.294117647058826%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eBMI (mean±SD, kg/m\u003csup\u003e2\u003c/sup\u003e)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"16.61764705882353%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e21.46±1.82\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"16.61764705882353%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e21.41±1.90\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.9pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"16.91176470588235%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e21.44±1.86\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 48.75pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"9.558823529411764%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.93\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 205.6pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"40.294117647058826%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eDuration of infertility (median/IQR, year)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"16.61764705882353%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e3 /2-5\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"16.61764705882353%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e3 /2-5\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.9pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"16.91176470588235%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e4 /2-5\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 48.75pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"9.558823529411764%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.40\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 205.6pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"40.294117647058826%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eType of infertility (n/%)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"16.61764705882353%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"16.61764705882353%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.9pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"16.91176470588235%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 48.75pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"9.558823529411764%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.86\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 205.6pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"40.294117647058826%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;text-indent:21.0pt;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003ePrimary infertility\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"16.61764705882353%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e250/46.2\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"16.61764705882353%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e267/45.6\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.9pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"16.91176470588235%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e67/48.2\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 48.75pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"9.558823529411764%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 205.6pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"40.294117647058826%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;text-indent:21.0pt;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eSecondary infertility\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"16.61764705882353%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e291/53.8\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"16.61764705882353%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e318/54.4\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.9pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"16.91176470588235%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e72/51.8\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 48.75pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"9.558823529411764%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 205.6pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"40.294117647058826%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eART indication (n/%)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"16.61764705882353%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"16.61764705882353%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.9pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"16.91176470588235%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 48.75pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"9.558823529411764%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.11\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 205.6pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"40.294117647058826%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;text-indent:21.0pt;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eMale factor\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"16.61764705882353%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e65/12.0\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"16.61764705882353%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e41/7.0\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.9pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"16.91176470588235%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e14/10.1\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 48.75pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"9.558823529411764%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 205.6pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"40.294117647058826%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;text-indent:21.0pt;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eTubal factor\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"16.61764705882353%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e386/71.3\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"16.61764705882353%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e460/78.6\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.9pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"16.91176470588235%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e105/75.5\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 48.75pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"9.558823529411764%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 205.6pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"40.294117647058826%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;text-indent:21.0pt;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003ePCOS\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"16.61764705882353%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e52/9.6\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"16.61764705882353%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e54/9.2\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.9pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"16.91176470588235%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e10/7.2\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 48.75pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"9.558823529411764%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 205.6pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"40.294117647058826%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;text-indent:21.0pt;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eDOR\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"16.61764705882353%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e13/2.4\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"16.61764705882353%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e8/1.4\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.9pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"16.91176470588235%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e4/2.9\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 48.75pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"9.558823529411764%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 205.6pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"40.294117647058826%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;text-indent:21.0pt;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eEndometriosis\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"16.61764705882353%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e25/4.6\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"16.61764705882353%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e22/3.8\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.9pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"16.91176470588235%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e6/4.3\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 48.75pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"9.558823529411764%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 205.6pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"40.294117647058826%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eMiscarriage History (n/%)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"16.61764705882353%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"16.61764705882353%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.9pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"16.91176470588235%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 48.75pt;border: none;padding: 0in 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none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"16.61764705882353%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e473/87.4\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"16.61764705882353%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e511/87.4\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.9pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"16.91176470588235%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e125/89.9\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 48.75pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"9.558823529411764%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 205.6pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"40.294117647058826%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;text-indent:21.0pt;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e1\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"16.61764705882353%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e54/10.0\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"16.61764705882353%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e58/9.9\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.9pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"16.91176470588235%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e9/6.5\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 48.75pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"9.558823529411764%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 205.6pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"40.294117647058826%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;text-indent:21.0pt;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e≥2\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"16.61764705882353%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e14/2.6\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"16.61764705882353%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e16/2.7\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.9pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"16.91176470588235%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e5/3.6\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 48.75pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"9.558823529411764%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 205.6pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"40.294117647058826%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eAMH (mean±SD, ng/ml)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"16.61764705882353%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e5.01±3.29\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"16.61764705882353%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e5.16±3.54\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.9pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"16.91176470588235%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e4.77±3.43\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 48.75pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"9.558823529411764%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.45\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 205.6pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"40.294117647058826%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eAFC (mean±SD)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"16.61764705882353%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e12.84±6.11\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"16.61764705882353%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e12.94±5.82\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.9pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"16.91176470588235%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e12.83±6.11\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 48.75pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"9.558823529411764%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.95\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 205.6pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"40.294117647058826%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eFertilization method (n/%)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"16.61764705882353%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"16.61764705882353%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.9pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"16.91176470588235%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 48.75pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"9.558823529411764%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.16\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 205.6pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"40.294117647058826%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;text-indent:21.0pt;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eIVF\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"16.61764705882353%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e368/68.0\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"16.61764705882353%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e431/73.7\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.9pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"16.91176470588235%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e93/66.9\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 48.75pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"9.558823529411764%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 205.6pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" 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valign=\"top\" width=\"16.61764705882353%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e107/18.3\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.9pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"16.91176470588235%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e30/21.6\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 48.75pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"9.558823529411764%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 205.6pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"40.294117647058826%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;text-indent:21.0pt;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eIVF + Rescue ICSI\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"16.61764705882353%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e47/8.7\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"16.61764705882353%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e47/8.0\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.9pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"16.91176470588235%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e16/11.5\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 48.75pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"9.558823529411764%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 205.6pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"40.294117647058826%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eStimulation protocol (n/%)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"16.61764705882353%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"16.61764705882353%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.9pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"16.91176470588235%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 48.75pt;border: none;padding: 0in 5.4pt;vertical-align: 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none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"16.61764705882353%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e309/57.1\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"16.61764705882353%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e361/61.7\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.9pt;border: none;padding: 0in 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none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"40.294117647058826%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;text-indent:21.0pt;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eGnRHa short\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"16.61764705882353%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e203/37.5\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"16.61764705882353%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e199/34.0\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.9pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"16.91176470588235%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e41/29.5\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 48.75pt;border: none;padding: 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style=\"width: 85.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"16.61764705882353%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e29/564.0\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"16.61764705882353%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e41/29.5\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.9pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"16.91176470588235%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e9/6.5\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 48.75pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"9.558823529411764%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 205.6pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"40.294117647058826%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eStarting does of Gn (mean±SD, IU)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"16.61764705882353%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e165.78±50.89\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"16.61764705882353%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e166.24±50.99\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.9pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"16.91176470588235%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e164.97±52.75\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 48.75pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"9.558823529411764%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.96\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 205.6pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"40.294117647058826%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eDays of stimulation (mean±SD, day)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"16.61764705882353%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e10.59±2.56\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"16.61764705882353%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e10.54±2.36\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.9pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"16.91176470588235%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e10.46±2.29\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 48.75pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"9.558823529411764%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.85\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 205.6pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"40.294117647058826%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eTotal dose of Gn (mean±SD, IU)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"16.61764705882353%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e1967.20±716.25\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"16.61764705882353%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e1952.97±677.84\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.9pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"16.91176470588235%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e1916.25±724.35\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 48.75pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"9.558823529411764%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.74\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 205.6pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"40.294117647058826%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eEndometrial thickness (mean±SD, mm)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"16.61764705882353%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e10.59±2.16\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"16.61764705882353%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e10.73±2.10\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.9pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"16.91176470588235%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e10.67±2.24\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 48.75pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"9.558823529411764%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.57\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 205.6pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"40.294117647058826%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eEndometrial pattern (n/%)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"16.61764705882353%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"16.61764705882353%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.9pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"16.91176470588235%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 48.75pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"9.558823529411764%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.67\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 205.6pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"40.294117647058826%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;text-indent:21.0pt;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eA\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"16.61764705882353%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e239/44.2\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"16.61764705882353%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e260/44.4\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.9pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"16.91176470588235%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e67/48.2\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 48.75pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"9.558823529411764%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 205.6pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"40.294117647058826%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;text-indent:21.0pt;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eB\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"16.61764705882353%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e278/51.4\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"16.61764705882353%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e290/49.6\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.9pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"16.91176470588235%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e66/47.5\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 48.75pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"9.558823529411764%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 205.6pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"40.294117647058826%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;text-indent:21.0pt;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eC\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"16.61764705882353%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e24/4.4\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"16.61764705882353%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e35/6.0\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.9pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"16.91176470588235%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e6/4.3\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 48.75pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"9.558823529411764%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 205.6pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"40.294117647058826%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eE\u003csub\u003e2\u003c/sub\u003e level at hCG Day (mean±SD, pg/ml)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"16.61764705882353%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e1948.44±1566.37\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"16.61764705882353%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e3066.93±1718.74\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.9pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"16.91176470588235%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e3006.04±1730.38\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 48.75pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"9.558823529411764%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.49\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 205.6pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"40.294117647058826%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eLH level at hCG Day (mean±SD, mIU/ml)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"16.61764705882353%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e1.98±1.53\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"16.61764705882353%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e2.02±1.49\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.9pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"16.91176470588235%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e1.98±1.32\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 48.75pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"9.558823529411764%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.86\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 205.6pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"40.294117647058826%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eP4 level at hCG Day (mean±SD, ng/ml)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"16.61764705882353%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.82±0.34\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"16.61764705882353%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.80±0.35\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.9pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"16.91176470588235%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.81±0.35\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 48.75pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"9.558823529411764%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.49\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 205.6pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"40.294117647058826%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eNo. of transferred embryos (mean±SD)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"16.61764705882353%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e1.91±0.29\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"16.61764705882353%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e1.92±0.28\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.9pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"16.91176470588235%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e1.91±0.28\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 48.75pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"9.558823529411764%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.92\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;text-align:justify;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eNote: MTHFR = 5,10-methylenetetrahydrofolate reductase, BMI = body mass index, SD = standard deviation, IQR = interquartile range, PCOS = polycystic ovarian syndrome, DOR = diminished ovarian reserve, AMH = anti mullerian hormone, AFC = antral follicle count, IVF = in-vitro fertilization, ICSI = intracytoplasmic sperm injection, Gn = gonadotrophin, No. = number, E2 = estradiol, LH = luteinizing hormone, P4 = progesterone, hCG = human chorionic gonadotrophin.\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eTable 2 Laboratory outcomes and clinical outcomes among the three genotypes of MTHFR C677T polymorphism.\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003ctable border=\"1\" cellpadding=\"0\" cellspacing=\"0\" style=\"width:467.8pt;margin-left:-35.7pt;border-collapse:collapse;border:none;\" width=\"624\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 163.05pt;border-top: 1pt solid windowtext;border-left: none;border-bottom: 1pt solid windowtext;border-right: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"34.88745980707395%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eLaboratory Outcomes\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border-top: 1pt solid windowtext;border-left: none;border-bottom: 1pt solid windowtext;border-right: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"18.167202572347268%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eMTHFR 677CC (n=541)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border-top: 1pt solid windowtext;border-left: none;border-bottom: 1pt solid windowtext;border-right: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"18.167202572347268%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eMTHFR 677CT (n=585)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border-top: 1pt solid windowtext;border-left: none;border-bottom: 1pt solid windowtext;border-right: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"18.167202572347268%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eMTHFR 677TT (n=139)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border-top: 1pt solid windowtext;border-left: none;border-bottom: 1pt solid windowtext;border-right: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"10.610932475884244%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eP-value\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 163.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"34.88745980707395%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eOocyte obtained (mean±SD)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"18.167202572347268%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e10.27±4.44\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"18.167202572347268%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e10.23±4.30\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"18.167202572347268%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e9.76±4.05\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"10.610932475884244%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.45\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 163.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"34.88745980707395%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eNo. of 2PNs (mean±SD)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"18.167202572347268%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e6.47±3.27\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"18.167202572347268%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e6.41±3.30\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"18.167202572347268%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e5.99±3.48\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"10.610932475884244%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.30\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 163.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"34.88745980707395%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eNo. of available embryos (mean±SD)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"18.167202572347268%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e4.20±2.54\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"18.167202572347268%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e4.18±2.47\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"18.167202572347268%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e3.86±2.52\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"10.610932475884244%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.34\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 163.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"34.88745980707395%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eNo. of good embryos (mean±SD)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"18.167202572347268%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e3.69±2.44\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"18.167202572347268%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e3.71±2.39\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"18.167202572347268%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e3.34±2.13\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"10.610932475884244%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.23\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 163.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"34.88745980707395%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"18.167202572347268%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"18.167202572347268%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"18.167202572347268%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"10.610932475884244%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 163.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"34.88745980707395%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eClinical Outcomes\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"18.167202572347268%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"18.167202572347268%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"18.167202572347268%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"10.610932475884244%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 163.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"34.88745980707395%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eImplantation rate (n/%)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"18.167202572347268%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e371/35.9\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"18.167202572347268%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e405/36.1\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"18.167202572347268%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e99/37.2\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"10.610932475884244%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.92\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 163.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"34.88745980707395%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eChemical pregnancy rate (n/%)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"18.167202572347268%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e323/59.7\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"18.167202572347268%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e350/59.8\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"18.167202572347268%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e84/60.4\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"10.610932475884244%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.99\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 163.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"34.88745980707395%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eClinical pregnancy rate (n/%)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"18.167202572347268%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e276/51.0\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"18.167202572347268%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e301/51.6\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"18.167202572347268%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e73/52.5\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"10.610932475884244%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.95\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 163.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"34.88745980707395%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003ePreclinical pregnancy loss rate(n/%)\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"18.167202572347268%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e48/8.9\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"18.167202572347268%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e48/8.2\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"18.167202572347268%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e11/7.9\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"10.610932475884244%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.90\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 163.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"34.88745980707395%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eMiscarriage rate (n/%)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"18.167202572347268%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e31/5.7\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"18.167202572347268%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e28/4.8\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"18.167202572347268%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e10/7.2\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"10.610932475884244%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.50\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 163.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"34.88745980707395%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eLive birth rate (n/%)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"18.167202572347268%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e236/43.6%\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"18.167202572347268%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e262/44.8\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"18.167202572347268%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e56/40.3\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"10.610932475884244%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.63\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 163.05pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"34.88745980707395%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eCumulative live birth rate (n/%)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"18.167202572347268%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e296/54.7\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"18.167202572347268%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e313/53.5\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"18.167202572347268%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e72/51.8\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"10.610932475884244%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.81\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eNote: MTHFR =\u0026nbsp;5,10-methylenetetrahydrofolate reductase, PN = pronucleus, SD = standard deviation.\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eTable 3 Odds ratios for association of live birth and \u003cem\u003eMTHFR\u003c/em\u003e genotype.\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003ctable border=\"1\" cellpadding=\"0\" cellspacing=\"0\" style=\"width:467.8pt;margin-left:-35.7pt;border-collapse:collapse;border:none;\" width=\"624\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"2\" style=\"width: 99.25pt;border-right: none;border-bottom: none;border-left: none;border-image: initial;border-top: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"21.153846153846153%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cem\u003eMTHFR\u003c/em\u003e C677T genotype\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width: 56.7pt;border-right: none;border-bottom: none;border-left: none;border-image: initial;border-top: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"12.179487179487179%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eNo. of live births, n\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width: 56.7pt;border-right: none;border-bottom: none;border-left: none;border-image: initial;border-top: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"12.179487179487179%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eLive birth rate, %\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width: 255.15pt;border-right: none;border-bottom: none;border-left: none;border-image: initial;border-top: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"54.48717948717949%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;text-align:center;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eOR (95% CI)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 85.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"33.333333333333336%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eModel 1 *\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"33.333333333333336%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eModel 2 \u0026amp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"33.333333333333336%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eModel 3 §\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 99.25pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"21.187800963081862%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eCC\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.7pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"12.199036918138042%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e236\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.7pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"12.199036918138042%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e43.6\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"18.13804173354735%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eRef.\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"18.13804173354735%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eRef.\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"18.13804173354735%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eRef.\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 99.25pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"21.187800963081862%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eCT\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.7pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"12.199036918138042%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e262\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.7pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"12.199036918138042%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e44.8\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"18.13804173354735%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e1.15 (0.79-1.68)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"18.13804173354735%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e1.13 (0.77-1.67)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"18.13804173354735%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e1.20 (0.81-1.77)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 99.25pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"21.187800963081862%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eTT\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.7pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"12.199036918138042%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e56\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.7pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"12.199036918138042%\"\u003e\n 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style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e1.20 (0.82-1.76)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"18.13804173354735%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e1.23 (0.83-1.80)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 99.25pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"21.187800963081862%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cem\u003eP\u003c/em\u003e-value for trend\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.7pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"12.199036918138042%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.7pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"12.199036918138042%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"18.13804173354735%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.63\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"18.13804173354735%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.63\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"18.13804173354735%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.59\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eNote: MTHFR = 5,10-methylenetetrahydrofolate reductase, CI = confidence interval, OR = odds ratio, Ref. = reference.\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e* Unadjusted\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026amp; Adjusted for age and BMI\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e§ Adjusted for age, BMI, stimulation protocol, ART indication, miscarriage history, endometrial thickness, and infertility type.\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"font-family: \n Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin:0in;margin-bottom:.0001pt;font-size:16px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0); font-size: 10px; font-family: Verdana, Geneva, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e"}],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":true,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":false,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":false,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"5,10-methylenetetrahydrofolate reductase, polymorphism, live birth rate, ART outcome ","lastPublishedDoi":"10.21203/rs.2.22704/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.2.22704/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003eBackgrounds: MTHFR is a key enzyme for folic acid metabolism and is important for reproduction. However, whether MTHFR C677T genotype affect live birth rate following IVF is unknown. This study aims to evaluate the association of MTHFR C677T polymorphism and live birth rate following IVF. \u003c/p\u003e\u003cp\u003eMethods: This is a retrospective cohort study of 1265 women undergoing first IVF -ET cycle (2015-2017) in Reproductive Medicine Center of Xiangya Hospital. The patients were followed for a minimum of 2 years and maximum of 5 years, the observation endpoint is live birth, or all the embryos derived from the first stimulation cycle are transferred. The study population was divided into three groups based on MTHFR C677T genotype (MTHFR 677CC, MTHFR 677CT, MTHFR 677TT). The primary outcomes are live birth rate and cumulative live birth. The secondary outcomes including laboratory parameters (number of oocytes, number of 2PNs, number of available embryos, number of good embryos) and clinical parameters (chemical pregnancy rate, clinical pregnancy rate, implantation rate, preclinical pregnancy loss rate, miscarriage rate). The logistic regression analysis with different adjusted models were used to analyze the association of MTHFR C677T genotype and live birth. \u003c/p\u003e\u003cp\u003eResults: Among the 1265 participants, 541 were MTHFR 677CC genotype, 585 were MTHFR 677CT genotype, and 139 were MTHFR 677TT genotype. The live birth rate\u0026nbsp;was 43.6%, 44.8%, and 40.3% (p-value = 0.63), and the cumulative live birth rate per stimulation cycle was 54.7%, 53.5%, and 51.8% (p-value =0.81) in MTHFR 677CC group, MTHFR 677CT group, and MTHFR 677TT group, respectively. The secondary laboratory outcomes and clinical outcomes were not significantly different between the three groups. Logistic regression analysis showed no significant association of MTHFR C677T genotype and live birth whether in model 1 (p-value for trend = 0.63) , model 2 (p-value for trend = 0.63), or model 3 (p-value for trend = 0.59). \u003c/p\u003e\u003cp\u003eConclusions: MTHFR C677T genotype does not significantly affect live birth rate and cumulative live birth rate following first IVF in Chinese Han couples.\u003c/p\u003e","manuscriptTitle":"Maternal MTHFR C677T polymorphism does not affect live birth rate following IVF in Chinese Han population: a retrospective cohort study of 1265 women","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2020-02-05 22:15:45","doi":"10.21203/rs.2.22704/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"cf8d4785-7f72-44e2-97ad-38bfddd8a9ba","owner":[],"postedDate":"February 5th, 2020","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[{"id":56061,"name":"Endocrinology \u0026 Metabolism"}],"tags":[],"updatedAt":"","versionOfRecord":[],"versionCreatedAt":"2020-02-05 22:15:45","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-13278","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"identity":"rs-13278","version":["v1"]},"buildId":"omnImTCwR2MFx8CMYfrG7","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}