Green pathway for the Construction of Aryl-1,8-Naphthyridine-Thiazole Scaffolds And In Vitro-Antimicrobial Evaluation, DNA-Binding Interactions, Viscosity Measurements, Molecular modeling Studies And ADME Properties

Environmentally friendly research can be bringing cost-effective technology it is essential and desirable in the current state-of-the-art research. Eco-friendly green synthesis of substituted aryl-1,8-naphthyridine-thiazole-4-carboxamide derivatives and evaluation of their biological studies antibacterial and antifungal activity of all the synthesized compounds demonstrated remarkable in-vitro microbial activity as well as DNA binding studies Viscosity Measurements by electronic absorption spectroscopy. The intrinsic binding constants (K b ) values of (5a-f) molecules with Ct-DNA obtained from UV-Vis spectroscopy. Molecular docking studies results and ADME properties were well complemented to the DNA-binding intercalative studies.