Uterine angiomyolipoma: a clinical analysis of 8 cases and literature review

Purpose Uterine angiomyolipoma (AML) is a rare condition involving benign tumors composed of varying proportions of blood vessels, fat, and epithelioid or spindled smooth muscle cells. We analyzed the clinicopathological features, diagnosis and treatment methods, and prognosis of uterine AML.

We retrospectively analyzed the clinical-pathological data of eight patients with pathologically diagnosed uterine AML at a single center from January 2008 to July 2020.

The mean age of the patients was 50 years (range, 41–62). One patient was asymptomatic; the main clinical manifestations of the others included vaginal bleeding (3), menorrhagia (2), abdominal pain (1), and dysmenorrhea with adenomyosis (1). In one case, fat components observed via abdominal computed tomography led to a diagnosis of uterine leiomyolipoma; the rest were diagnosed as uterine leiomyoma (4), uterine fibroid degeneration (2), and pelvic mass (1). The lesions were in the body of the uterus (6), the fundus of the uterus (1), and the broad ligament (1). Seven patients had a focal soft tumor texture, and one had a tough texture; the lesions were yellow (3), yellow-white (3), and pinkish white (2). Surgeries included transabdominal myomectomy (2), transabdominal hysterectomy (2), transabdominal hysterectomy/bilateral salpingo-oophorectomy (2), and laparoscopic total hysterectomy/bilateral salpingectomy (2). The median follow-up time was 72 months. No relapses were reported.

Uterine AML has a low incidence rate and is most likely to occur in perimenopausal women. The clinical manifestations are similar to those of uterine leiomyomas, but AML should be suspected if the internal echo of the uterine tumor is uneven and contains adipose tissue. Similar content being viewed by others Availability of data and material All data and material are fully available without restriction.

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This work was supported by the National Natural Science Foundation of China (No. 81872125), and the local Technology and Development Key Program of Liaoning Province (No. 2019416020). Funding This work was supported by the National Natural Science Foundation of China (No. 81872125), and the local Technology and Development Key Program of Liaoning Province (No. 2019416020). Author information Authors and Affiliations Contributions All authors contributed to the study conception and design. Material preparation, data collection and analysis were performed by Jiao Wang, Qing Yang and Ningning Zhang. The first draft of the manuscript was written by Jiao Wang, Dandan Wang was responsible for critical revision of the manuscript and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript. Corresponding author Ethics declarations Conflicts of interest The authors declare no competing interests. Ethics approval This study was approved by the Institutional Review Board of Shengjing Hospital of China Medical University. Consent to participate Informed consent was obtained from all the patients. Consent for publication Informed consent to publish was obtained from all the patients. Additional information Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Rights and permissions About this article Cite this article Wang, J., Yang, Q., Zhang, N. et al. Uterine angiomyolipoma: a clinical analysis of 8 cases and literature review. Arch Gynecol Obstet 304, 171–177 (2021). https://doi.org/10.1007/s00404-021-05992-1 Received: Accepted: Published: Version of record: Issue date: DOI: https://doi.org/10.1007/s00404-021-05992-1