Pathogenesis of Endometriosis and Future Approaches

Pathogenesis of Endometriosis and Future Approaches Authors/Creators Description Endometriosis is an estrogen-dependent female disease associated with pelvic pain and infertility as a result of abnormal placement of endometrial tissue outside the uterus.Endometriosis, which affects approximately 200 million women worldwide, continues to be an important health problem today due to its uncertainties about its pathogenesis. Since the disease was identified, many different pathogenetic pathways have been considered, such as retrograde menstruation, benign metastasis, immune disorders, hormonal imbalances, involvement of stem cells, and changes in epigenetic regulation. Interaction of the number and amount of menstrual flows with genetic and environmental factors seems to determine the likelihood of development as well as the phenotypic manifestation of the disease However, the true pathogenesis of endometriosis is not fully understood. Therefore, in this review, we outline recent developments that illuminate the main origin and pathogenesis of endometriosis based on current studies and provide new avenues for research that promises to improve early diagnosis and treatment of endometriosis. Although endometriosis is generally thought to be a steroid-sensitive disease, one of the possible causes of the development of endometriosis may be the immune system. A thorough understanding of the histopathogenesis and pathophysiology of endometriosis is essential for the development of new diagnostic and therapeutic approaches to this debilitating condition. Files Pathogenesis-of-Endometriosis-and-Future-Approaches.pdf Files (429.5 kB) | Name | Size | Download all | |---|---|---| | md5:4bc3cffd5722057e955b511a1bafdc85 | 429.5 kB | Preview Download | Additional details References - Wang, Y., Nicholes, K., & Shih, I. M. (2020). The origin and pathogenesis of endometriosis. Annual Review of Pathology: Mechanisms of Disease, 15, 71-95. - Nap, A. W., Groothuis, P. G., Demir, A. Y., Evers, J. L., & Dunselman, G. A. (2004). Pathogenesis of endometriosis. Best practice & research Clinical obstetrics & gynaecology, 18(2), 233-244. - Burney RO, Giudice LC. 2012. Pathogenesis and pathophysiology of endometriosis. Fertil. Steril. 98:511– 19 - Dağdeviren Tuğba, 2024. İnsan Endometriozis Dokusunda Nükleer Faktör Kappa B Yolağı Ve Bcl-2 Etkileşiminin Olası Rolü: Morfometrik Ve Histolojik Bir Çalışma, Doktora Tezi, Cumhuriyet Üniversitesi Sağlık Bilimleri Enstitüsü - Dyson MT, Roqueiro D, Monsivais D, Ercan CM, Pavone ME et al. 2014. Genome-wide DNA methylation analysis predicts an epigenetic switch for GATA factor expression in endometriosis. PLOS Genet 10:e1004158