Myocardial performance imaging for the early identification of cardiac dysfunction in neonates with sepsis

Abstract Purpose: The assessment of cardiac performance in septic new-borns is crucial for detecting hemodynamic instability and predicting outcome. The aim of the study is to assess myocardial performance in neonates with sepsis for the early identification of cardiac dysfunction Material and methods: A case control study was carried out from September 2022 to May 2023 at the NICU, KMC, Manipal. A total of 68 neonates were included in the study, with 33 female and 35 males. The study population was further subdivided into 3 groups namely preterm septic neonates (n=21), term septic neonates (n=10) and non-septic healthy controls (n=37). The cardiac structure and function were assessed using conventional method, Tissue Doppler imaging (Sm) and speckle tracking echocardiography (GLS) The study was approved by the Institutional Ethics Committee, Kasturba Medical College, Manipal (approval number IEC: 90/2022). The CTRI registration number for the study is CTRI/2022/09/045437 and was approved on September 12, 2022. Prior to the neonate’s enrolment, informed consent was obtained from their mothers or legal guardians. Results: Out of the total 68 neonates, 31 were cases and 37 were controls which included 33 females and 35 males. LV systolic function was not statistically significant between cases and controls. E/A ratio of the mitral valve was significantly lower in septic newborns than in healthy neonates. preterm neonates showed significantly lower Lateral E’ and RV E’ velocities than term neonates. TAPSE was significantly lower in septic preterm neonates. No significant difference was noted in MPI between septic neonates and healthy neonates.LV GLS was slightly lower in preterm septic neonates than in term neonates with sepsis Conclusion: Septic newborns are associated with LV diastolic dysfunction, RV systolic dysfunction and substantially higher pulmonary systolic pressures.