Development trajectory and predictive factors of demoralization syndrome in cervical cancer patients undergoing postoperative concurrent chemoradiotherapy

Development trajectory and predictive factors of demoralization syndrome in cervical cancer patients undergoing postoperative concurrent chemoradiotherapy | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Development trajectory and predictive factors of demoralization syndrome in cervical cancer patients undergoing postoperative concurrent chemoradiotherapy Yanfang Zhang, Xiaomei Ji, Yuanyuan Yu, Manman Hu, Li Wang, Lihua Wang, and 3 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-8052126/v1 This work is licensed under a CC BY 4.0 License Status: Under Review Version 1 posted 7 You are reading this latest preprint version Abstract Objective To examine the developmental trajectories of DS and its influencing factors among cervical cancer patients undergoing postoperative CCRT. Methods A convenience sample of cervical cancer patients treated at a hospital in Anhui Province from June 2023 to March 2025 will be recruited. The Demoralization Scale will be administered at five time points: 3–7 days after surgery to three months after the final chemotherapy. Growth Mixture Modeling (GMM) will be used to identify trajectories of DS over time.The Wilcoxon rank-sum test and multiple logistics regression were used to analyze the influencing factors for the DS trajectories. Results Three DS trajectories were identified: Persistent Group(46.6%), Adjustment Group(45.7%) and Remission Group(7.7%). The social support, coping styles, and psychological resilience as key factors influencing DS trajectories. Conclusions Group heterogeneity in DS was observed in cervical cancer patients undergoing postoperative CCRT. Social support, coping styles, and psychological resilience should be considered by healthcare professionals to deliver appropriate psychosocial care. Cervical cancer cancer chemotherapy concurrent chemoradiotherapy demoralization syndrome longitudinal study oncology psycho-oncology trajectories Full Text Additional Declarations No competing interests reported. Cite Share Download PDF Status: Under Review Version 1 posted Editorial decision: Revision requested 25 Apr, 2026 Reviews received at journal 04 Apr, 2026 Reviewers agreed at journal 23 Mar, 2026 Reviewers invited by journal 25 Feb, 2026 Editor assigned by journal 07 Dec, 2025 Submission checks completed at journal 12 Nov, 2025 First submitted to journal 06 Nov, 2025 You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-8052126","acceptedTermsAndConditions":true,"allowDirectSubmit":false,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":597288867,"identity":"097cc0e9-3533-4ab6-849f-417c9fbd85e1","order_by":0,"name":"Yanfang Zhang","email":"","orcid":"","institution":"Bengbu Medical University","correspondingAuthor":false,"prefix":"","firstName":"Yanfang","middleName":"","lastName":"Zhang","suffix":""},{"id":597288868,"identity":"8a37fc6b-4ed2-4d6b-b68a-940dfceea178","order_by":1,"name":"Xiaomei Ji","email":"","orcid":"","institution":"Bengbu Medical 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Hybrid","inReviewEnabled":true,"inReviewRevisionsEnabled":false},"keywords":"Cervical cancer, cancer, chemotherapy, concurrent chemoradiotherapy, demoralization syndrome, longitudinal study, oncology, psycho-oncology, trajectories","lastPublishedDoi":"10.21203/rs.3.rs-8052126/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-8052126/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003ch2\u003eObjective\u003c/h2\u003e \u003cp\u003eTo examine the developmental trajectories of DS and its influencing factors among cervical cancer patients undergoing postoperative CCRT.\u003c/p\u003e\u003ch2\u003eMethods\u003c/h2\u003e \u003cp\u003eA convenience sample of cervical cancer patients treated at a hospital in Anhui Province from June 2023 to March 2025 will be recruited. The Demoralization Scale will be administered at five time points: 3\u0026ndash;7 days after surgery to three months after the final chemotherapy. Growth Mixture Modeling (GMM) will be used to identify trajectories of DS over time.The Wilcoxon rank-sum test and multiple logistics regression were used to analyze the influencing factors for the DS trajectories.\u003c/p\u003e\u003ch2\u003eResults\u003c/h2\u003e \u003cp\u003eThree DS trajectories were identified: Persistent Group(46.6%), Adjustment Group(45.7%) and Remission Group(7.7%). The social support, coping styles, and psychological resilience as key factors influencing DS trajectories.\u003c/p\u003e\u003ch2\u003eConclusions\u003c/h2\u003e \u003cp\u003eGroup heterogeneity in DS was observed in cervical cancer patients undergoing postoperative CCRT. Social support, coping styles, and psychological resilience should be considered by healthcare professionals to deliver appropriate psychosocial care.\u003c/p\u003e","manuscriptTitle":"Development trajectory and predictive factors of demoralization syndrome in cervical cancer patients undergoing postoperative concurrent chemoradiotherapy","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2026-03-02 11:17:36","doi":"10.21203/rs.3.rs-8052126/v1","editorialEvents":[{"type":"communityComments","content":0},{"type":"decision","content":"Revision requested","date":"2026-04-25T15:44:34+00:00","index":"","fulltext":""},{"type":"editorInvitedReview","content":"","date":"2026-04-04T08:33:01+00:00","index":"hide","fulltext":""},{"type":"reviewerAgreed","content":"319520674884487883536205007368781390796","date":"2026-03-23T14:29:58+00:00","index":"hide","fulltext":""},{"type":"reviewersInvited","content":"","date":"2026-02-26T04:37:24+00:00","index":"","fulltext":""},{"type":"editorAssigned","content":"","date":"2025-12-08T02:17:47+00:00","index":"","fulltext":""},{"type":"checksComplete","content":"","date":"2025-11-12T23:27:32+00:00","index":"","fulltext":""},{"type":"submitted","content":"Supportive Care in Cancer","date":"2025-11-07T01:56:51+00:00","index":"","fulltext":""}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"supportive-care-in-cancer","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"jscc","sideBox":"Learn more about [Supportive Care in Cancer](https://www.springer.com/journal/520)","snPcode":"520","submissionUrl":"https://submission.nature.com/new-submission/520/3","title":"Supportive Care in Cancer","twitterHandle":"","acdcEnabled":true,"dfaEnabled":true,"editorialSystem":"stoa","reportingPortfolio":"Springer Hybrid","inReviewEnabled":true,"inReviewRevisionsEnabled":false}}],"origin":"","ownerIdentity":"94209582-c271-4f0b-ab6e-9a74a2409fd5","owner":[],"postedDate":"March 2nd, 2026","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"under-review","subjectAreas":[],"tags":[],"updatedAt":"2026-05-01T12:08:16+00:00","versionOfRecord":[],"versionCreatedAt":"2026-03-02 11:17:36","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-8052126","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-8052126","identity":"rs-8052126","version":["v1"]},"buildId":"XKTyCvWXoU3ODBz1xrDgd","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}