Effects of PKF 115–584 on cell proliferation.

A, B: Basal cell proliferation in non-treated endometrial epithelial (A) and stromal (B) cells of patients with and without endometriosis. C, D: Percent inhibition of cell proliferation in endometrial epithelial (C) and stromal (D) cells of patients with and without endometriosis treated with PKF 115–584. Results are presented as the mean+SEM. Basal cell proliferation is presented as OD. Percent inhibition of cell proliferation is calculated as percent of vehicle control. M: menstrual phase, P: proliferative phase, ES: early secretory phase, MS: mid- secretory phase, LS: late secretory phase. Endo (+): Endometrium of patients with endometriosis (M: n = 6, P: n = 20, ES: n = 7, MS: n = 15, LS: n = 6). Endo (–): endometrium of patients without endometriosis (M: n = 4, P: n = 11, ES: n = 8, MS: n = 8, LS: n = 4). a: p<.05 versus patients without endometriosis.