The correlation between the changes of levels of MCP-1and IGF-Iin peritoneal fluid and pathogenesis of endometriosis and infertility

Objective: The aim of the study was to investigate the role of monocyte chemotactic protein-1(MCP-1)and Insulin-like growth factorsI(IGF-I) in the endometriosis pathogenesis and infertile.Methods:Peritoneal fluid and ectopic endometrial tissues of 30 patients with endometriosis(10 early stage and 20 severe stage;12 with infertility and 18 without infertility) and 10 no-endometriosis were obtained.The ELISA was employed to measured MCP-1 and IGF-I levels.Results:(1)The levels of MCP-1and IGF-I in the peritoneal fluid and ectopic endometrial tissues were significantly elevated in EM group as compared with those in control group(10cases)(P0.01);especially the levels of MCP-1and IGF-Ⅰof the peritoneal fluid and MCP-1 level of ectopic endometrial tissues were significantly higher in early stages than those in severe stages(P0.05).(2) The level of peritoneal fluid IGF-Ⅰwas found to be significantly higher in patients with infertility than those of without infertility(P0.05).Conclusion:Our results indicated that the changes of MCP-1and IGF-Ⅰmay play some roles in the pathogenesis of endometriotic lesions.