Analysis of the characteristics of blood lipid metabolism in twin pregnancy

Objective: This study aimed to investigate the characteristics of blood lipid metabolism in twin pregnancy and its combined with gestational diabetes mellitus (GDM) or pregnancy-induced hypertension (PIH). Methods: This study retrospectively analyzed 96 cases of twin pregnancy and 232 cases of full-term singleton pregnancy, and they were filed in our hospital, undergone antenatal examination and gave birth from March 2016 to March 2021. Among 96 cases of twin pregnancy, 22 cases had GDM, and 18 cases had gestational hypertension. Comparison of general data and blood lipid levels, including triglyceride (TG) and total cholesterol (TC), between twin pregnancy and singleton pregnancy was performed. Comparison of blood lipid levels between GDM group and non-GDM group in twin pregnancy was performed. Comparison of blood lipid levels between the PIH group and the non-PIH group in twin pregnancy was performed. Results For the twin pregnancy, the TG level in the third trimester was higher than that in the second and first trimester, and the TG level in the second trimester was higher than that in the first trimester (P < 0.05). For the twin pregnancy, the TC level in the second and third trimester was higher than that in the first trimester (P  0.05). The TG level of twin pregnancy was higher than that of singleton pregnancy in the first, second and third trimesters (P  0.05). For the twin pregnancy, the TG level in the GDM group was higher than that in the non-GDM group (P  0.05). The TG level in the first, second and third trimester of twin pregnancy combined with PIH group was higher than that in the non-hypertensive group (P  0.05). Conclusions The lipid levels in twin pregnancy increased with the increase of gestational age, and the TG level in twin pregnancy complicated with GDM or PIH was higher than that in twin pregnancy without with GDM or PIH, indicating that the blood lipid metabolism was related to the occurrence of GDM and PIH in twin pregnancy to some extent.