Estrogen and progesterone dose-dependently reduce disruptive effects of restraint on lordosis behavior

Stacy White, Lynda Uphouse
Hormones and behavior · 2004 · vol. 45(3) , pp. 201–208 · doi:10.1016/j.yhbeh.2003.10.001 · PMID:15047015 · W2003304556
Lab / animal OA: closed CC0 ⤵ 5 in-corpus citations
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This study found that specific doses of estrogen and progesterone dose-dependently prevented restraint stress from inhibiting lordosis behavior in ovariectomized rats, highlighting hormonal regulation of stress responses.

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Abstract

Ovariectomized rats were hormonally primed with various doses of estradiol benzoate (EB; 0.5-10 microg) in combination with various doses of progesterone (2.5-500 microg) to induce sexual receptivity. Females were then subjected to 5 min restraint and the effect on lordosis behavior was monitored for the next 30 min. Such mild stress has been previously shown to transiently reduce lordosis behavior of ovariectomized females hormonally primed only with 10 microg EB. In the current study, doses of progesterone of 25 microg or more in combination with 10 microg EB reduced the effects of restraint. Also priming doses of EB from 4.0 to 10 microg in combination with 250 microg progesterone prevented the lordosis-inhibiting effects of restraint. These findings reinforce prior observations of the dose-dependency of both estrogen and progesterone in the facilitation of lordosis behavior and introduce the female's lordosis response to mild restraint as a potentially useful index of the female's response to stress.

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MeSH descriptors

Estradiol Estradiol Posture Progesterone Restraint, Physical Sexual Behavior, Animal Stress, Psychological Animals Dose-Response Relationship, Drug Drug Therapy, Combination Estradiol Female Ovariectomy Progesterone Rats Rats, Inbred F344 Sexual Behavior, Animal Sexual Behavior, Animal Stress, Psychological

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