alpha-1-Antitrypsin, alpha-1-antichymotrypsin, actin, and myosin in uterine sarcomas

Marshall RJ, R J Marshall, Braye SG, S G Braye
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists · 1985 · vol. 4(4) , pp. 346–54 · doi:10.1097/00004347-198512000-00007 · PMID:3878832
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Immunohistochemical analysis of uterine sarcomas, leiomyomas, and mixed müllerian tumors revealed distinct expression patterns of alpha-1-antitrypsin, alpha-1-antichymotrypsin, actin, and myosin to aid in histological classification.

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This study utilized immunoperoxidase techniques to evaluate the expression of alpha-1-antitrypsin, alpha-1-antichymotrypsin, actin, and myosin in various uterine tumors. The researchers analyzed fourteen mixed müllerian tumors, six stromal sarcomas, five leiomyosarcomas, five leiomyomas, and six endometrial adenocarcinomas to compare protein markers against normal uterine tissue. Results indicated that most malignant and benign smooth muscle tumors expressed these specific proteins, with varying positivity rates for each marker across the different histological subtypes. The paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.

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Abstract

Fourteen cases of mixed müllerian tumour (MMT) of the endometrium, six stromal sarcomas, five uterine leiomyosarcomas, and five leiomyomas were examined, using an immunoperoxidase technique, for the presence of alpha-1-antitrypsin (A1AT), alpha-1-antichymotrypsin (A1ACT), actin, and myosin. In addition, six cases of endometrial adenocarcinoma were examined for the presence of A1AT and A1ACT. Eleven MMT were positive for A1AT and 13 for A1ACT. All stromal sarcomas, four adenocarcinomas, four leiomyomas, and three leiomyosarcomas were positive for both. All leiomyomas and leiomyosarcomas were positive for myosin as were seven. MMT and three stromal sarcomas. Four leiomyomas, four leiomyosarcomas, six MMT, and three stromal sarcomas were positive for actin. These findings are related to those in the normal uterus and their practical and theoretical significance discussed.
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α-1-Antitrypsin, α-1-Antichymotrypsin, Actin, and Myosin in Uterine Sarcomas - Robert J. Marshall - Stephen G. Braye Summary Fourteen cases of mixed müllerian tumour (MMT) of the endometrium, six stromal sarcomas, five uterine leiomyosarcomas, and five leiomyomas were examined, using an immunoperoxidase technique, for the presence of α-1-antitrypsin (A1AT), α-1-antichymotrypsin (A1ACT), actin, and myosin. In addition, six cases of endometrial adenocarcinoma were examined for the presence of A1AT and A1ACT. Eleven MMT were positive for AlAT and 13 for A1ACT. All stromal sarcomas, four adenocarcinomas, four leiomyomas, and three leiomyosarcomas were positive for both. All leiomyomas and leiomyosarcomas were positive for myosin as were seven MMT and three stromal sarcomas. Four leiomyomas, four leiomyosarcomas, six MMT, and three stromal sarcomas were positive for actin. These findings are related to those in the normal uterus and their practical and theoretical significance discussed.

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MeSH descriptors

Sarcoma Uterine Neoplasms Actins Actins Adenocarcinoma Adenocarcinoma alpha 1-Antichymotrypsin alpha 1-Antitrypsin alpha 1-Antitrypsin Chymotrypsin Chymotrypsin Chymotrypsin Endometriosis Endometriosis Female Histocytochemistry Humans Leiomyoma Leiomyoma Leiomyosarcoma

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