Overexpression Of RNPEPL1 Predicts Poor Overall Survival In Ovarian Carcinoma

Abstract Background. RNPEPL1 (arginyl aminopeptidase-like 1) belongs to the M1 family of zinc metallopeptidases. We aimed to explore the role of RNPEPL1 in the occurrence and progression of ovarian carcinoma (OV).Methods: We analyzed the expression level and prognostic value of RNPEPL1 in OV across Oncomine, GEO, TCGA and Human Protein Atlas (HPA) database and identified its prognostic value by the Cox regression analysis and Kaplan–Meier method. We utilized GESA software to perform GO and KEGG analyses. We also utilized TIMER to evaluate the relevance between RNPEPL1 and tumor-infiltrating immune cells. Finally, relevance between RNPEPL1 and immune-related genes was examined by Pearson correlation analysis.Results: RNPEPL1 was overexpressed in OV tissues compared with normal ovary tissue. Moreover, high RNPEPL1 expression was related with poor OV survival in TCGA. Cox analyses suggested that overexpression of RNPEPL1 was an independent risk factor for overall survival(OS) of OV. Results of KEGG analysis suggested that genes were mainly enriched in T cell receptor signaling pathway, B cell receptor signaling pathway and natural killer cell mediated cytotoxicity when the expression level of RNPEPL1 is low. Besides, RNPEPL1 expression is associated with infiltrating levels of CD4+ T cells, B cells, macrophage, neutrophils and dendritic cells. And, the level of dendritic cells is correlated with OS of OV. RNPEPL1 expression was significantly correlated with the immune signaling pathway of antigen processing and presentation.Conclusions: RNPEPL1 is a novel independently prognostic biomarker of OV and was related to immune infiltration. Especially, the tight correlation between RNPEPL1 and antigen processing and presentation may be the potential hub of anti-tumor immunity and one of the essential factors influencing survival.