Clinical features and image manifestations of recurrent retinoblastoma with limb bone metastasis and without CNS involvement

Clinical features and image manifestations of recurrent retinoblastoma with limb bone metastasis and without CNS involvement | Authorea try { document.documentElement.classList.add('js'); } catch (e) { } var _gaq = _gaq || []; _gaq.push(['_setAccount', 'G-8VDV14Y67G']); _gaq.push(['_trackPageview']); (function() { var ga = document.createElement('script'); ga.type = 'text/javascript'; ga.async = true; ga.src = ('https:' == document.location.protocol ? 'https://ssl' : 'http://www') + '.google-analytics.com/ga.js'; var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(ga, s); })(); Skip to main content Preprints Collections Wiley Open Research IET Open Research Ecological Society of Japan All Collections About About Authorea FAQs Contact Us Quick Search anywhere Search for preprint articles, keywords, etc. Search Search ADVANCED SEARCH SCROLL This is a preprint and has not been peer reviewed. Data may be preliminary. 31 January 2024 V1 Latest version Share on Clinical features and image manifestations of recurrent retinoblastoma with limb bone metastasis and without CNS involvement Authors : Huali Gu 0000-0002-4620-6296 , Zhuo Wang , Dongsheng Huang 0000-0001-6347-9811 [email protected] , Xunda Ji , Yi Zhang , Jian-Min Ma , ling Zhang , Hui-Min Hu , Pinwei Zhang , and You Yi Authors Info & Affiliations https://doi.org/10.22541/au.170667979.94995158/v1 276 views 164 downloads Contents Abstract Supplementary Material Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Background: Retinoblastoma (RB) is the most common intraocular malignancy in infancy and childhood. Bone metastases are common and usually involve the skull and axial bones; limb bone metastases are rare. Herein, we evaluated the clinical features, image manifestations, treatment, and prognosis of patients with recurrent RB with limb bone metastasis and without central neural system involvement. Procedure: Clinical data of 5 patients with retinoblastoma who were diagnosed at the Department of Pediatrics in Beijing Tongren Hospital, between January 2015 and January 2021, were retrospectively analyzed. Results: Three males and two females were included (7 eyes: 4 stage E and 1 each of stage D, C, and B). The interval between symptom onset and bone metastasis was 12-102 months. Three cases were unilateral (2 left and 1 right), and two were bilateral. The most common symptom was pain. Three patients had bone marrow and lymph node metastasis. Three patients had single and two had multiple skeletal lesions. The main limb bones involved were the femur, humerus, talus, and ulna. Serum neuron specific enolase (NSE) was significantly elevated in 4 cases, and slightly elevated in 1 case; primary intravenous chemotherapy resulted in a decrease in NSE and gradual resolution of bone lesions. At the time of follow-up, 2 patients died and 3 were in complete remission. Conclusions: Regular lifelong follow-up of patients with RB is warranted to identify bone metastases. Clinicians should consider examination findings, imaging findings, and laboratory results to identify bone metastases and initiate appropriate treatment. Supplementary Material File (2021-8-24rb骨转移.doc) Download 101.00 KB File (table_1_clinical_characteristics_and_laboratory_results_of_recurrent_rb_patients_with_serious_limb_bone_metastasis.docx) Download 24.97 KB Information & Authors Information Version history V1 Version 1 31 January 2024 Copyright This work is licensed under a Non Exclusive No Reuse License. Keywords bone metastasis limb bone metastasis nse recurrent retinoblastoma Authors Affiliations Huali Gu 0000-0002-4620-6296 Beijing Tongren Hospital View all articles by this author Zhuo Wang Beijing Tongren Hospital View all articles by this author Dongsheng Huang 0000-0001-6347-9811 [email protected] Beijing Tongren Hospital View all articles by this author Xunda Ji Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine View all articles by this author Yi Zhang Beijing Tongren Hospital View all articles by this author Jian-Min Ma Beijing Tongren Hospital View all articles by this author ling Zhang Beijing Tongren Hospital View all articles by this author Hui-Min Hu Beijing Tongren Hospital View all articles by this author Pinwei Zhang Beijing Tongren Hospital View all articles by this author You Yi Beijing Tongren Hospital View all articles by this author Metrics & Citations Metrics Article Usage 276 views 164 downloads .FvxKWukQNSOunydq8rnd { width: 100px; } Citations Download citation Huali Gu, Zhuo Wang, Dongsheng Huang, et al. Clinical features and image manifestations of recurrent retinoblastoma with limb bone metastasis and without CNS involvement. Authorea . 31 January 2024. DOI: https://doi.org/10.22541/au.170667979.94995158/v1 If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download. For more information or tips please see 'Downloading to a citation manager' in the Help menu . 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