Efficient Synthesis of New Azoimino-sulfathiazole and Considering Their Antibacterial, Antioxidant and Cytotoxic Activities

Sulfonamides are important compounds that have special applications in pharmacy due to their antibacterial and anti-parasitic properties and are known as sulfa-drugs. One of the most important drugs is sulfathiazole. This drug has many uses in the treatment of diseases. In this research, the hybrid reaction between sulfathiazole and various azo compounds was performed via the imine bond. Here, nine new azoiminosulfathiazoles were synthesized, while compound 5g was designed in such a way that two sulfathiazole units were linked by an azo linker. The structure of the newly synthesized hybrid molecules after separation and purification was examined and confirmed by TLC, M.P, FT-IR, 1 H NMR, and 13 C NMR, and their cytotoxicity was evaluated via MTT assay. Evaluation of antibacterial and antioxidant and anticancer again (PC-3) human prostate line cells using MTT assay properties also showed acceptable results. Comparing 5g with penicillin as a standard drug with the aura of non-growth of bacteria (31 mm) in the presence of Staphylococcus aureus (27 mm) and in the presence of E.coli bacteria showed that it has the best antibacterial properties. Also, evidence shows that some compounds have more effective antibacterial activity than penicillin.