TGM2 is highly expressed and active in endometriosis where it mediates pro-fibrotic and pro-inflammatory effects

Estrada, F, Obendorf, M, Mesch, S, Shang, C, Becker, C., Guo, M, Fischer, O, Bafligil, C, Kennedy, S, Zondervan, K, Gordon, S, Zollner, T, Oppermann, U
· W7024996354
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Transglutaminase 2 (TGM2) is highly expressed and active in endometriosis, where it drives pro-fibrotic and pro-inflammatory processes.

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⚙ AI-generated deep summary by qwen3.7-flash, 2026-09-04 · read from full text ⓘ

This study investigated the role of transglutaminase 2 (TGM2) in endometriosis, identifying that the enzyme is highly expressed and active within endometrial lesions compared to normal tissue. The authors demonstrated through experimental models that TGM2 activity drives both pro-fibrotic and pro-inflammatory pathways, which are characteristic features of endometriotic disease progression. While the abstract highlights these mechanistic insights, it does not detail specific clinical outcomes or therapeutic interventions derived from this molecular analysis. This paper is centrally about endometriosis — specifically examining the molecular mechanisms involving TGM2-mediated fibrosis and inflammation in lesion formation.

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Conference item : Abstract TGM2 is highly expressed and active in endometriosis where it mediates pro-fibrotic and pro-inflammatory effects - Publication status: - Published - Peer review status: - Peer reviewed Actions Access Document - Files: - - (Preview, Accepted manuscript, pdf, 64.3KB, Terms of use) - - Publisher copy: - 10.1177/1933719117699545 Authors - Publisher: - SAGE Publications - Host title: - Reproductive Sciences - Journal: - Reproductive Sciences More from this journal - Volume: - 24 - Issue: - 1S - Pages: - 141A-142A - Publication date: - 2017-03-01 - DOI: - EISSN: - 1933-7205 - ISSN: - 1933-7191 - Subtype: - Abstract - Pubs id: - pubs:718761 - UUID: - uuid:c494695b-5a58-4af3-9885-319e7c719f0d - Local pid: - pubs:718761 - Source identifiers: - 718761 - Deposit date: - 2018-05-30 - ARK identifier: Terms of use - Copyright holder: - Estrada et al - Copyright date: - 2017 - Notes: - This abstract was presented at the 64th Annual Scientific Meeting of the Society for Reproductive Investigation, March 15 - 18, 2017 in Orlando, FL. If you are the owner of this record, you can report an update to it here: Report update to this record

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endometriosis

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