Potential protective effect of a G>A SNP in the 3'UTR of HLA-A for Chlamydia trachomatis symptomatology and severity of infection

Marleen E Jansen, Me Jansen, Ivan Branković, Joke Spaargaren, S Ouburg, Sander Ouburg, Servaas A Morré, Sa Morré
Pathogens and disease · 2015 · vol. 74(2) , pp. ftv116 · doi:10.1093/femspd/ftv116 · PMID:26656886 · PMC4857152 · W2425781715
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This study found that the HLA-A G>A SNP rs1655900 is not associated with Chlamydia trachomatis susceptibility but may protect against tubal pathology, a major cause of female infertility.

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Abstract

The interindividual differences in response to Chlamydia trachomatis (CT) infections are for an important part based on the differences in our host genetic make-up. In the past, several genes and pathways have been identified and linked to protection against or risk for CT infection (i.e. susceptibility), and/or the severity of infection, with a major emphasis on the development of tubal pathology, one of the main causes of female infertility. In the current study, we analyzed in Dutch Caucasian women whether the carriage of HLA-A G>A SNP (rs1655900) was related to the susceptibility of CT infection in a STD cohort (n = 329) and to the severity of infection in a subfertility cohort (n = 482). We also investigated if this A-allele was linked to increase in severity of symptoms, from mild symptoms (lower genital infection) to lower abdominal pain (upper genital tract infection) to the most severe late complication of tubal pathology, including double-sided tubal pathology. We showed that the carriage of HLA-A SNP rs1655900 studied is not associated with the susceptibility to CT infection based on the data from the STD cohort, but might be protective to the development of late complications (p = 0.0349), especially tubal pathology could be relevant.

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Condition tags

infertility

MeSH descriptors

3' Untranslated Regions Chlamydia Infections Chlamydia Infections Chlamydia trachomatis Chlamydia trachomatis Genetic Predisposition to Disease HLA-A Antigens Host-Pathogen Interactions Polymorphism, Single Nucleotide Alleles Chlamydia Infections Chlamydia Infections Chlamydia Infections Cohort Studies Female Genotype HLA-A Antigens HLA-A Antigens Host-Pathogen Interactions Host-Pathogen Interactions

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