Comparative Study of Solvent Effect for tryptophan Oxidation by Different Oxidants

Quinaldinium fluorochromate (QnFC), imidazolium fluorochromate (IFC), quinoxalinium dichromate (QxDC), imidazolium chlorochromate (ICC), and quinaldinium chlorochromate (QnCC) have all performed tryptophan oxidation at 308K using various solvents, including dimethyl sulphoxide (DMSO), dimethyl formamide (DMF),acetone, dichloromethane (DCM) and 1,2-dichloroethane (DCE). This has led to the formation of the corresponding indole-3-acetaldehyde. We examined the solvent effect using the Technique for Order of Preference by Similarity to Ideal Solution ( TOPSIS) method, and the solvent performance score for the reaction revealed the following order: DMSO > DMF > DCE > DCM > ACETONE. Corresponding indole-3-acetaldehyde were formed as a result of the oxidation process with all of the oxidants.