Influence of 6-keto-PGF1α on collagen synthesis in the human cervix during various phases of the menstrual cycle

L. Wilhelmsson, Anders Norström, Lars Hamberger
In: Prostaglandins · 1981 · vol. 22(1) , pp. 125–130 · doi:10.1016/0090-6980(81)90059-9 · PMID:7027323 · W2078538616
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Abstract

Uterine cervix tissue, obtained from nonpregnant fertile women undergoing hysterectomy, was mechanically chopped into 1 mm thick slices and incubated in Krebs-Ringer bicarbonate buffer containing 6-keto-PGF1 alpha (0.03-10 microgram/ml) and 3H-proline. After incubation of 30-120 min the incorporated radioactivity was determined and related to the protein content of each slice. 6-keto-PGF1 alpha had specific and significant effects on the incorporation of 3H-proline into cervical tissue. In the follicular phase of the cycle a decreased incorporation was registered, indicating a reduced net synthesis of protein. However, increased radiolabelling was observed in the luteal phase, reflecting an augmented protein synthesis. It is suggested that 6-keto-PGF1 alpha, the stable metabolite of prostacyclin (PGI2), has the ability to influence cervical protein metabolism and that this effect is steroid hormone dependent.

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