IMMUNITY AND INFECTION IN WOMEN WITH HYPERPLASTIC STATES OF IMMUNE SYSTEM

А. А. Лукач, O. A. Minyailo, В. И. Коновалов, A. I. Olkhovikov, Nikolay V. Kungurov, N. M. Gerasimova, Н. П. Евстигнеева, Ya. B. Beykin
In: Medical Immunology (Russia) · 2014 · vol. 10(2-3) , pp. 223 · doi:10.15789/1563-0625-2008-2-3-223-228 · W1723873124
article OA: diamond CC0
🔓 Open OA copy Full text JSON View on OpenAlex View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-08-11 ⓘ

In women with reproductive system hyperplastic states, Chlamydia or Ureaplasma infections correlated with systemic immune disorders, including decreased monocytes, neutrophils, and impaired cytokine-synthesizing activity of CD3+ lymphocytes.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

⚙ AI-generated deep summary by gpt-5.6-luna, 2026-08-12 · read from full text ⓘ

The paper addresses immunity and infection in women with hyperplastic processes of the reproductive system, but the supplied text contains only the title, author information, references, and citation details. Consequently, its study population, methods, findings, and explicitly stated limitations cannot be determined from the available material. The paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.

Read from the paper's body, not the abstract. Not a substitute for reading the paper. No clinical advice. How this works

Abstract

One hundred and ninety-nine patients with hyperplastic processes of reproductive system were examined, and 131 (66.16%) of them were found to be infected with Chlamydia or Ureaplasma. The mean age of female patients was 42,7±1,35 years. Different infectious agents (e.g. Chlamydia trachomatis, Ureaplasma urealiticum, Mycoplasma hominis) were identified in cervical canal of uterine cervix and surgical specimens (biopsy samples of excised myoma, adenomyosis or endometrial hyperplasia). The infected patients were found to have decreased monocytes and neutrophils in blood counts, lower phagocytic activity of monocytes and neutrophils, and decreased bactericidal activity of leukocytes. Other findings included lower CD20+, CD8+ and rFAS CD 95 lymphocytes. Assessment of cytokine-synthesizing activity of CD3+ lymphocytes showed a decrease in both spontaneous and stimulated response (р < 0,001). A weakest spontaneous and stimulated response was found in CD3+/IL-4+ lymphocytes. Analysis of results obtained shows systemic immune disorders and impaired cytokine-synthesizing activity of CD3+ lymphocytes correlating with infection factors in the women with hyperplastic processes of reproductive system. (Med. Immunol., 2008, vol. 10, N 2-3, pp 223-228) .
Full text 3,242 characters · extracted from oa-doi-fallback · click to expand
ИММУНИТЕТ И ИНФЕКЦИЯ У ЖЕНЩИН С ГИПЕРПЛАСТИЧЕСКИМИ ПРОЦЕССАМИ РЕПРОДУКТИВНОЙ СИСТЕМЫ https://doi.org/10.15789/1563-0625-2008-2-3-223-228 Аннотация Об авторах А. А. ЛукачРоссия О. А. Миняйло Россия В. И. Коновалов Россия А. И. Ольховиков Россия 620073, г. Екатеринбург, ул. Луначарского, 171, кв. 84 Н. В. Кунгуров Россия Н. М. Герасимова Россия Н. П. Евстигнеева Россия Я. Б. Бейкин Россия Список литературы 1. Башмакова М.А., Савичева А.М. Генитальные микоплазмы и микоплазменные инфекции // Трудный пациент. – 2006. – Т. 4, № 2. – С. 24-30. 2. Карамова А.Э., Поляков А.В., Комарова Н.В., Хамаганова И.В. Цервицит и Ureaplasma urealyticum // Рос. журн. кожных и венер. болезней. – 2005. – № 6. – С. 9-13. 3. Мазуров Д.В., Дамбаева С.В., Пинегин Б.В. Оценка внутриклеточного киллинга стафилококка фагоцитами периферической крови с помощью проточной цитометрии // Иммунология. – 2000. – № 2. – С. 57-59. 4. Потехин О.Е., Малышев В.С. Роль инфекции Chlamydiae pneumoniae в развитии атеросклероза сосудов сердца // Кремлевская медицина. Клинический вестник. – 1998. – № 1. – С. 13-17. 5. Салехов С.А., Андриевская М.А., Корабельникова И.А., Решетникова Г.В., Нирозник В.В. О диагностике хламидийной и микоплазменной урогенитальной инфекции / Охрана здоровья матери и ребенка, 2000. Роль инфекции в патологии репродуктивной системы женщины, плода и новорожденного // Сб. тезисов. – М., 2000. – С. 260-261. 6. Сухих Г.Т., Ванько Л.В. Механизмы иммунной защиты при острых и хронических заболеваниях органов репродуктивной системы // Акушерство и гинекология. – 2006. – Приложение. – С. 17-24. 7. Цинкернагель Р. Об иммунологической памяти // Казанский медицинский журнал. – 2007. – Т. 88, № 1. – С. 1-4. 8. Anderson J.I., Muhlestein J.B., Carlquist J., Allen A., Trehan S., Nielson C., Hall S., Brady J., Egger M., Horue B., Lim T. Randomized secondary prevention trial of azithromycin in patients with coronary artery disease and serological evidence for Chlamydia pneumoniae infection: the azithromycin in coronary artery disease: elimination of myocardial infection with Chlamydia (ACADEMIC) study // Circulation. – 1999. – Vol. 99, N 12. – P. 1540-1547. 9. Engelmann M.G., Nikol S. Atherosclerosis as inflammatory disease: Impact of Chlamydia pneumoniae and latest insights in whether or not prevention using antibiotics makes sense // e-Journal of Cardiology Practice. – 2003. – Vol. 2, N 7. 10. Gupta S. Chronic infection in the aetiology of atherosclerosis – focus on Chlamydia pneumoniae [The John French Memorial Lecture] // Atherosclerosis. – 1999. – Vol. 143. – P. 1-6. Рецензия Для цитирования: Лукач А.А., Миняйло О.А., Коновалов В.И., Ольховиков А.И., Кунгуров Н.В., Герасимова Н.М., Евстигнеева Н.П., Бейкин Я.Б. ИММУНИТЕТ И ИНФЕКЦИЯ У ЖЕНЩИН С ГИПЕРПЛАСТИЧЕСКИМИ ПРОЦЕССАМИ РЕПРОДУКТИВНОЙ СИСТЕМЫ. Медицинская иммунология. 2008;10(2-3):223-228. https://doi.org/10.15789/1563-0625-2008-2-3-223-228 For citation: Lukach A.A., Minyailo O.A., Konovalov V.I., Olkhovikov A.I., Kungurov N.V., Gerasimova N.M., Evstigneeva N.P., Beykin Ya.B. IMMUNITY AND INFECTION IN WOMEN WITH HYPERPLASTIC STATES OF IMMUNE SYSTEM. Medical Immunology (Russia). 2008;10(2-3):223-228. (In Russ.) https://doi.org/10.15789/1563-0625-2008-2-3-223-228 JATS XML

Text is read by the "Ask this paper" AI Q&A widget below. Extraction quality varies by source — PMC NXML preserves structure cleanly, OA-HTML may include some navigation residue, and OA-PDF can have broken hyphenation. The publisher copy (via DOI) is the canonical version.

My notes (saved in your browser only)

⚙ Ask this paper AI returns verbatim quotes from the full text · source: oa-doi-fallback ⓘ

Answers must be backed by verbatim quotes from this paper's full text. Hallucinated quotes are dropped automatically; if no verbatim passage answers the question, we say so. How this works

Condition tags

adenomyosis

Citation neighborhood (no data yet)

We don't have any in-corpus citations linked to this paper yet. The paper's references may be in our DB but unresolved to ``paper_id`` (resolution happens at ingest when the cited DOI matches a row we already have). Run the cross-source citation reconcile pass to retry.

Source provenance

openalex
last seen: 2026-06-04T00:00:01.174412+00:00
License: CC0 · commercial use OK