Clinical Value of Residual Cervical Biopsy during Cervical Conization: A Comprehensive Analysis

Clinical Value of Residual Cervical Biopsy during Cervical Conization: A Comprehensive Analysis | Authorea try { document.documentElement.classList.add('js'); } catch (e) { } var _gaq = _gaq || []; _gaq.push(['_setAccount', 'G-8VDV14Y67G']); _gaq.push(['_trackPageview']); (function() { var ga = document.createElement('script'); ga.type = 'text/javascript'; ga.async = true; ga.src = ('https:' == document.location.protocol ? 'https://ssl' : 'http://www') + '.google-analytics.com/ga.js'; var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(ga, s); })(); Skip to main content Preprints Collections Wiley Open Research IET Open Research Ecological Society of Japan All Collections About About Authorea FAQs Contact Us Quick Search anywhere Search for preprint articles, keywords, etc. Search Search ADVANCED SEARCH SCROLL This is a preprint and has not been peer reviewed. Data may be preliminary. 12 May 2026 V1 Latest version Share on Clinical Value of Residual Cervical Biopsy during Cervical Conization: A Comprehensive Analysis Authors : Zhang Xinyan [email protected] , Chen Lili [email protected] , Yu Qin [email protected] , Li Ping [email protected] , and Zhao Hongxia [email protected] Authors Info & Affiliations https://doi.org/10.22541/authorea.15003097/v1 18 views 5 downloads Contents Abstract Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Objective To evaluate the predictive value of concurrent residual cervical biopsy during cervical conization for residual lesions in women with high-grade squamous intraepithelial lesion (HSIL), and to identify risk factors for residual disease and pathological downgrading to guide clinical management. Design Retrospective observational study. Setting Single tertiary obstetrics and gynaecology centre in China (The 970th Hospital of the Joint Logistics Support Force, Yantai, Shandong, China). Population or Sample 108 patients who underwent cold knife conization for HSIL between January 2023 and December 2024. Methods Intraoperative multi-point biopsy of the residual cervix was performed in all cases. Associations between conization margin status, clinicopathological factors, and residual lesions were analysed using logistic regression. Main Outcome Measures Residual lesion rate; independent risk factors for residual disease; pathological downgrading rate and related factors. Results Residual lesions were detected in 22.2% of patients. Positive conization margins were associated with a significantly higher residual positive rate (60.0% vs 7.7%, P<0.001). Independent risk factors for residual disease were age ≥40 years (OR 3.25, 95%CI 1.12–9.43), HPV16/18 infection (OR 4.12, 95%CI 1.45–11.76), and glandular involvement (OR 5.54, 95%CI 1.94–15.85). Pathological downgrading occurred in 25.9% of patients and was associated with age 8 weeks. Conclusions Intraoperative residual cervical biopsy is safe and feasible for real-time assessment of surgical completeness and detection of occult lesions. Margin status, age, HPV16/18, and glandular involvement reliably stratify residual risk. This strategy supports individualised postoperative care and reduces recurrence risk in women with HSIL. Information & Authors Information Version history V1 Version 1 12 May 2026 Keywords GYNAECOLOGICAL SURGERY: GYNAECOLOGICAL CANCER CARCINOMA OF THE CERVIX: DIAGNOSIS CARCINOMA OF THE ENDOMETRIUM: DIAGNOSIS CARCINOMA OF THE OVARY: DIAGNOSIS CIN: DIAGNOSIS CYTOLOGY: ENDOMETRIAL EPIDEMIOLOGY: GYNAECOLOGICAL CANCER CYTOLOGY: CERVICAL PATHOLOGY: GYNAECOLOGICAL CARCINOMA OF THE CERVIX: DIAGNOSIS ADENOMYOSIS: BASIC SCIENCE GYNAECOLOGICAL SURGERY: GYNAECOLOGICAL CANCER CARCINOMA OF THE CERVIX: DIAGNOSIS CARCINOMA OF THE ENDOMETRIUM: DIAGNOSIS CARCINOMA OF THE OVARY: DIAGNOSIS CIN: DIAGNOSIS CYTOLOGY: ENDOMETRIAL EPIDEMIOLOGY: GYNAECOLOGICAL CANCER Authors Affiliations Zhang Xinyan [email protected] 970th Hospital of the Joint Logistics Support Force, Yantai, China View all articles by this author Chen Lili [email protected] 970th Hospital of the Joint Logistics Support Force, Yantai, China View all articles by this author Yu Qin [email protected] 970th Hospital of the Joint Logistics Support Force, Yantai, China View all articles by this author Li Ping [email protected] 970th Hospital of the Joint Logistics Support Force, Yantai, China View all articles by this author Zhao Hongxia [email protected] 970th Hospital of the Joint Logistics Support Force, Yantai, China View all articles by this author Metrics & Citations Metrics Article Usage 18 views 5 downloads .FvxKWukQNSOunydq8rnd { width: 100px; } Citations Download citation Zhang Xinyan, Chen Lili, Yu Qin, et al. Clinical Value of Residual Cervical Biopsy during Cervical Conization: A Comprehensive Analysis. Authorea . 12 May 2026. DOI: https://doi.org/10.22541/authorea.15003097/v1 If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download. For more information or tips please see 'Downloading to a citation manager' in the Help menu . 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