Development of Narrow Spectrum ATP-competitive Kinase Inhibitors as Probes for BIKE and AAK1
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Abstract
ABSTRACT Understanding the structural determinants of inhibitor selectivity would facilitate the design and preparation of kinase probes. We describe a pair of matched compounds differing only by one degree of saturation but showing dramatic differential activities at select kinases. We utilized x-ray crystallography and computational analysis to rationalize the basis of the differential activity.
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- europepmc
- last seen: 2026-05-19T01:45:01.086888+00:00