High live birth rates after laparoscopic isthmocele repair in infertility: a systematic review and meta-analysis.

Vidal, Angela, Geiger, James, Vinayahalingam, Vithusha, Pape, Janna, Gulz, Marietta, Karrer, Tanya, Mueller, Michael D., von Wolff, Michael
2025 · doi:10.48620/88271 · W6910678204
article OA: green CC0
🔓 Open OA copy Full text JSON View on OpenAlex View at publisher
⚙ AI-generated summary by qwen3.7-flash, 2026-09-12 ⓘ

A systematic review and meta-analysis found that laparoscopic isthmocele repair yields high live birth rates in women with or without infertility, noting a 29% prevalence of co-existing endometriosis among participants.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

⚙ AI-generated deep summary by claude@2026-06, 2026-06-17 · read from full text ⓘ

I can’t access the actual paper content because the provided text is blocked by an anti-bot “Anubis” page, so the study’s methods, findings, and limitations aren’t available to summarize. Without the paper’s full text (or an abstract with results and limitations), I would have to guess, which would violate your requirement to base the summary only on the paper’s information. The paper title suggests it is a systematic review and meta-analysis of laparoscopic isthmocele repair outcomes for infertility, but those details can’t be verified from the text shown. The paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.

Read from the paper's body, not the abstract. Not a substitute for reading the paper. No clinical advice. How this works

Abstract

Background Cesarean sections are becoming more common worldwide. One of the long-term complications of cesarean section is a cesarean scar defect or isthmocele. The presence of isthmocele is associated with infertility.Objectives This systematic review and meta-analysis examined the effect of laparoscopic isthmocele repair on the reproductive outcomes of patients with and without infertility.Search Strategy We searched MEDLINE, EMBASE, and the Cochrane CENTRAL databases in April 2024.Selection Criteria The study included cohort studies, case-control studies, and case series reporting reproductive outcomes after laparoscopic isthmocele repair among women with or without diagnosed infertility.Data Collection And Analysis The meta-analysis examined rates of live birth, pregnancy, and miscarriage.Main Results The search identified 866 records and 17 articles were included. Clinical pregnancy rates after isthmocele resection were 62% (95% confidence interval (CI) 54-69%) in women with infertility, compared to 33% (95% CI: 16-57%) in women without infertility and 36% in women with unknown fertility status (36%, 95% CI: 21-55%). Live birth rates were 72% (95% CI: 54-85%) among those with infertility, 78% (95% CI: 46-94%) among those without infertility, and 61% (95% CI: 42-77%) with unknown fertility status. Women with and without infertility had low miscarriage rates of 10% (95% CI: 6-16%) and 7% (95% CI: 3-18%), respectively. The prevalence of co-existing endometriosis was 29% (95% CI: 22-37%). The statistical heterogeneity of the studies ranged from 0 to 86%.Conclusions Laparoscopic isthmocele repair has demonstrated the potential to improve reproductive outcomes, specifically in cases where infertility is linked to isthmocele-related factors, such as challenges during embryo transfer or impaired implantation. However, further well-designed multicenter trials must confirm these findings and provide stronger evidence.Systematic Review Registration https://www.crd.york.ac.uk/prospero/, identifier (CRD42024548864).
Full text 1,068 characters · extracted from oa-html · click to expand
Making sure you're not a bot! Loading... You are seeing this because the administrator of this website has set up Anubis to protect the server against the scourge of AI companies aggressively scraping websites. This can and does cause downtime for the websites, which makes their resources inaccessible for everyone. Anubis is a compromise. Anubis uses a Proof-of-Work scheme in the vein of Hashcash, a proposed proof-of-work scheme for reducing email spam. The idea is that at individual scales the additional load is ignorable, but at mass scraper levels it adds up and makes scraping much more expensive. Ultimately, this is a placeholder solution so that more time can be spent on fingerprinting and identifying headless browsers (EG: via how they do font rendering) so that the challenge proof of work page doesn't need to be presented to users that are much more likely to be legitimate. Please note that Anubis requires the use of modern JavaScript features that plugins like JShelter will disable. Please disable JShelter or other such plugins for this domain.

Text is read by the "Ask this paper" AI Q&A widget below. Extraction quality varies by source — PMC NXML preserves structure cleanly, OA-HTML may include some navigation residue, and OA-PDF can have broken hyphenation. The publisher copy (via DOI) is the canonical version.

My notes (saved in your browser only)

⚙ Ask this paper AI returns verbatim quotes from the full text · source: oa-html ⓘ

Answers must be backed by verbatim quotes from this paper's full text. Hallucinated quotes are dropped automatically; if no verbatim passage answers the question, we say so. How this works

Condition tags

endometriosisinfertility

Citation neighborhood (no data yet)

We don't have any in-corpus citations linked to this paper yet. This is a recent paper (2025) — citers typically take a year or two to land, and the OpenAlex reference graph may still be filling in.

Source provenance

openalex
last seen: 2026-05-10T11:22:19.371297+00:00
License: CC0 · commercial use OK