Expression of MIF and VEGF protein and the significance in endometriosis

Objective To investigate the expression and association of MIF and VEGF in the endometriosis.Methods Immunohistochemistry method was used to detect the expression of MIF and VEGF protein in 30 cases of ectopic endometrium,30 cases of eutopic endometrium and 30 cases of endometrium without endometriosis.Results MIF and VEGF protein were expressed in epithelial cells of ecpotic,eutopic and control endometrium.MIF protein was significantly higher in epithelial cells of ecpotic endometrium than in that of eutopic endometrium and control endometrium(P0.05).VEGF protein was significantly higher in epithelial cells of ecpotic endometrium and eutopic endometrium than in that of control endometrium(P0.05).The expression of MIF in ectopic endometrium epithelial cells had a positive relationship with that of VEGF.Conclusion The overexpressions of MIF and VEGF in epithelial cells of ecpotic endometrium both contribute to angiopoiesis and might be of importance for migratory,adherence,invasion and growth of ectopic endometrium,which may result in endometriosis.