The Impact of Splenectomy on Human Lipid Metabolism

Background: Splenectomy impacts hematological, immunological and metabolic functions of the patient. Since our understanding of its metabolic effects, in particular effects on lipid metabolism, are limited, this study aims to investigate the effects of splenectomy on lipid metabolism. Methods: The data from 316 patients undergoing splenectomy between 2009 and 2019 were retrospectively analyzed. Thirty-eight patients whose blood lipid values ​​were measured both preoperatively and one year after surgery were included in the study. Results: Significantly higher levels of total cholesterol and low-density lipoprotein were found in the post – splenectomy measurements. However, no significant differences were recorded in levels of triglyceride, high-density lipoprotein, or very-low-density lipoprotein. Conclusion: We determined that splenectomy does impact lipid metabolism and that the metabolic effects of splenectomy should be further investigated.