RARB, a gene associated with MSI gastric cancer, affects progression and prognosis of gastric cancer

Abstract MSI gastric cancer exhibits greater sensitivity to immunotherapy due to its own characteristics. Here, we firstly identified the RARB gene associated with MSI gastric cancer, which was positively correlated with mismatch repair proteins(MMR).Although relatively low in expression in MSI gastric cancer, RARB promotes gastric cancer progression and leads to poor prognosis. However, we found that in cellular experiments, lowering the expression of RARB accelerated the proliferation, invasion and migration of cancer cells and promoted the EMT. The contradictory reasons for these two results may be related to the tumor immune microenvironment. RARB may be a potential target for the treatment of gastric cancer.