Editorial: Vaginal dysbiosis and biofilms, volume II

António Machado, Machado A, Claudio Foschi, Foschi C, Antonella Marangoni, Marangoni A
Frontiers in cellular and infection microbiology · 2025 · vol. 15 , pp. 1588434 · doi:10.3389/fcimb.2025.1588434 · PMID:40176981 · PMC11962028
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This editorial introduces the second volume of research on vaginal dysbiosis and biofilms, highlighting current knowledge and future directions in the field.

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This editorial introduces a research topic exploring the complex interactions between vaginal microbiota, host responses, and biofilms in reproductive health. It summarizes multiple studies examining diagnostic methods, therapeutic interventions, and the impact of microbial imbalances on conditions such as bacterial vaginosis, candidiasis, and uterine fibroids. The collection highlights how specific bacterial species and their metabolic products influence disease pathogenesis and potential treatment strategies for various gynecological disorders. Relevance to endometriosis: listed among other gynecological diseases like endometrial polyps and adenomyosis in a review by Zheng et al., which suggests that microbiota-targeted interventions may offer therapeutic avenues for these conditions.

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References

1 CeccaraniC.FoschiC.ParolinC.D’AntuonoA.GaspariV.ConsolandiC.et al. (2019). Diversity of vaginal microbiome and metabolome during genital infections. Sci. Rep.9, 1–12. doi: 10.1038/s41598-019-50410-x 2 De GregorioP. R.ParolinC.AbruzzoA.LuppiB.ProttiM.MercoliniL.et al. (2020). Biosurfactant from vaginal Lactobacillus crispatus BC1 as a promising agent to interfere with Candida adhesion. Microb. Cell Fact19, 1–16. doi: 10.1186/s12934-020-01390-5 3 HenriquesA.CereijaT.MachadoA.CercaN. (2012). In silico vs in vitro analysis of primer specificity for the detection of Gardnerella vaginalis, Atopobium vaginae and Lactobacillus spp. BMC Res. Notes5, 637. doi: 10.1186/1756-0500-5-637 4 MachadoA.CastroJ.CereijaT.AlmeidaC.CercaN. (2015). Diagnosis of bacterial vaginosis by a new multiplex peptide nucleic acid fluorescence in situ hybridization method. PeerJ3, e780. Available at: https://peerj.com/articles/780/ (Accessed March 01, 2025). 5 MachadoA.FoschiC.MarangoniA. (2022). Editorial: Vaginal dysbiosis and biofilms. Front. Cell Infect. Microbiol.12. doi: 10.3389/fcimb.2022.976057 6 MachadoA.SalgueiroD.HarwichM.JeffersonK. K.CercaN. (2013). Quantitative analysis of initial adhesion of bacterial vaginosis-associated anaerobes to ME-180 cells. Anaerobe23, 1–4. doi: 10.1016/j.anaerobe.2013.07.007 7 MorselliS.CeccaraniC.DjusseM. E.LaghiL.CamboniT.ConsolandiC.et al. (2024). Anti-chlamydial activity of vaginal fluids: new evidence from an in vitro model. Front. Cell Infect. Microbiol.14. doi: 10.3389/fcimb.2024.1403782 8 Muñoz-BarrenoA.Cabezas-MeraF.TejeraE.MachadoA. (2021). Comparative effectiveness of treatments for bacterial vaginosis: A network meta-analysis. Antibiotics10, 1–16. doi: 10.3390/antibiotics10080978 9 ParolinC.MarangoniA.LaghiL.FoschiC.PalominoR.A. Ñ.CalonghiN.et al. (2015). Isolation of vaginal lactobacilli and characterization of anti-candida activity. PloS One10, 1–17. doi: 10.1371/journal.pone.0131220 10 Rodríguez-AriasR. J.Guachi-ÁlvarezB. O.Montalvo-ViveroD. E.MachadoA. (2022). Lactobacilli displacement and Candida albicans inhibition on initial adhesion assays: a probiotic analysis. BMC Res. Notes15, 1–7. doi: 10.1186/s13104-022-06114-z 11 SalinasA. M.OsorioV. G.EndaraP. F.SalazarE. R.VascoG. P.ViveroS. G.et al. (2018). Bacterial identification of the vaginal microbiota in Ecuadorian pregnant teenagers: an exploratory analysis. PeerJ6, e4317. doi: 10.7717/peerj.4317 Summary

Keywords

biofilms, vaginal dysbiosis, reproductive health, vaginal microbiota, accurate diagnostics, antimicrobial resistance, novel treatments Citation Machado A, Foschi C and Marangoni A (2025) Editorial: Vaginal dysbiosis and biofilms, volume II. Front. Cell. Infect. Microbiol. 15:1588434. doi: 10.3389/fcimb.2025.1588434 Received 05 March 2025 Accepted 10 March 2025 Published 19 March 2025 Volume 15 - 2025 Edited and reviewed by Christophe Beloin, Institut Pasteur, France Updates Copyright © 2025 Machado, Foschi and Marangoni. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. *Correspondence: António Machado, [email protected]; [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

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