Mortality in Adult Patients Admitted at Regional Hospital Bamenda Between 2015-2025 for Decompensated Liver Cirrhosis.

Mortality in Adult Patients Admitted at Regional Hospital Bamenda Between 2015-2025 for Decompensated Liver Cirrhosis. | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Mortality in Adult Patients Admitted at Regional Hospital Bamenda Between 2015-2025 for Decompensated Liver Cirrhosis. Pius- Mary Kindong Nchindo, Fomukong Shenny Nina, Ngrassou Dassou, and 1 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-8359376/v1 This work is licensed under a CC BY 4.0 License Status: Under Review Version 1 posted 8 You are reading this latest preprint version Abstract Background: Once decomposition has occurred, liver cirrhosis becomes a systemic disease. In turn, patients are burdened by a high risk of death. This worked aimed to study the mortality in adult patients admitted for decompensated liver cirrhosis at the Regional Hospital Bamenda. Specifically, to determine the mortality rate, identify the aetiologies of liver cirrhosis, and determine factors associated with mortality among our study participants. Methods : A cross-sectional analytical study was conducted involving 250 patients aged ≥18 years diagnosed with decompensated liver cirrhosis (DLC) at the Regional Hospital Bamenda. Data on Sociodemographic characteristics, clinical parameters, and outcomes were collected. Bivariate and multivariate logistic regression analyses were performed to identify factors independently associated with mortality. Results : Out of 46,301 patients admitted to the Regional Hospital Bamenda between 2015 and 2025, 250 adults with DLC were included in this study. The mean age was 48.31±14.91 years, with a male predominance (78.8%). The overall in-hospital mortality was 52.8%. Hepatitis B (68.0%), alcoholic liver disease (13.6%), and hepatitis C (11.2%) were the most common aetiologies of liver cirrhosis identified. Upon bivariate analysis, age >40 years, renal failure, hyponatremia, spontaneous bacterial peritonitis (SBP), and Child-Pugh class B/C were recruited for inclusion into the multivariate model. Multivariate logistic regression revealed that age >40 years [OR: 2.207; 95% CI, p=0.003], SBP (OR: 8.357, 95%CI, p=0.005), renal failure (OR: 2.190, 95% CI, p=0.044), hyponatremia (OR: 1.849, 95% CI, p=0.003), and Child-Pugh class B/C (OR: 1.862, 95% CI, p=0.030) were independent predictors of in-hospital mortality among patients with DLC. Conclusions : The in-hospital mortality of decompensated liver cirrhosis in the Regional Hospital Bamenda is very high. Chronic viral hepatitis and alcohol are the most encountered aetiologies of liver cirrhosis. Traditional factors: age >40 years, spontaneous bacterial peritonitis, renal failure, hyponatremia, and advanced Child-Pugh class (B/C) are independent predictors of in-hospital mortality. Decompensated liver cirrhosis mortality Hepatitis Bamenda Full Text Additional Declarations No competing interests reported. Cite Share Download PDF Status: Under Review Version 1 posted Reviews received at journal 28 Jan, 2026 Reviewers agreed at journal 18 Jan, 2026 Reviewers agreed at journal 15 Jan, 2026 Reviewers invited by journal 13 Jan, 2026 Editor assigned by journal 12 Jan, 2026 Editor invited by journal 23 Dec, 2025 Submission checks completed at journal 22 Dec, 2025 First submitted to journal 22 Dec, 2025 You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-8359376","acceptedTermsAndConditions":true,"allowDirectSubmit":false,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":575274468,"identity":"62960647-b7b6-41ae-a626-e444265dc442","order_by":0,"name":"Pius- Mary Kindong 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Cirrhosis.\u003c/p\u003e","fulltext":[],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":false,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":false,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":true,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":true,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"bmc-gastroenterology","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"bmge","sideBox":"Learn more about [BMC Gastroenterology](http://bmcgastroenterol.biomedcentral.com/)","snPcode":"","submissionUrl":"https://www.editorialmanager.com/bmge/default.aspx","title":"BMC Gastroenterology","twitterHandle":"BMC_series","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"em","reportingPortfolio":"BMC Series","inReviewEnabled":true,"inReviewRevisionsEnabled":true},"keywords":"Decompensated liver cirrhosis, mortality, Hepatitis, Bamenda","lastPublishedDoi":"10.21203/rs.3.rs-8359376/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-8359376/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003e\u003cstrong\u003eBackground:\u003c/strong\u003e Once decomposition has occurred, liver cirrhosis becomes a systemic disease. In turn, patients are burdened by a high risk of death. This worked aimed to study the mortality in adult patients admitted for decompensated liver cirrhosis at the Regional Hospital Bamenda. Specifically, to determine the mortality rate, identify the aetiologies of liver cirrhosis, and determine factors associated with mortality among our study participants.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eMethods\u003c/strong\u003e: A cross-sectional analytical study was conducted involving 250 patients aged ≥18 years diagnosed with decompensated liver cirrhosis (DLC) at the Regional Hospital Bamenda. Data on Sociodemographic characteristics, clinical parameters, and outcomes were collected. Bivariate and multivariate logistic regression analyses were performed to identify factors independently associated with mortality.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eResults\u003c/strong\u003e: Out of 46,301 patients admitted to the Regional Hospital Bamenda between 2015 and 2025, 250 adults with DLC were included in this study. The mean age was 48.31±14.91 years, with a male predominance (78.8%). The overall in-hospital mortality was 52.8%. Hepatitis B (68.0%), alcoholic liver disease (13.6%), and hepatitis C (11.2%) were the most common aetiologies of liver cirrhosis identified. Upon bivariate analysis, age \u0026gt;40 years, renal failure, hyponatremia, spontaneous bacterial peritonitis (SBP), and Child-Pugh class B/C were recruited for inclusion into the multivariate model. Multivariate logistic regression revealed that age \u0026gt;40 years [OR: 2.207; 95% CI, p=0.003], SBP (OR: 8.357, 95%CI, p=0.005), renal failure (OR: 2.190, 95% CI, p=0.044), hyponatremia (OR: 1.849, 95% CI, p=0.003), and Child-Pugh class B/C (OR: 1.862, 95% CI, p=0.030) were independent predictors of in-hospital mortality among patients with DLC.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eConclusions\u003c/strong\u003e: The in-hospital mortality of decompensated liver cirrhosis in the Regional Hospital Bamenda is very high. Chronic viral hepatitis and alcohol are the most encountered aetiologies of liver cirrhosis. Traditional factors: age \u0026gt;40 years, spontaneous bacterial peritonitis, renal failure, hyponatremia, and advanced Child-Pugh class (B/C) are independent predictors of in-hospital mortality.\u003c/p\u003e","manuscriptTitle":"Mortality in Adult Patients Admitted at Regional Hospital Bamenda Between 2015-2025 for Decompensated Liver Cirrhosis.","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2026-01-16 19:39:05","doi":"10.21203/rs.3.rs-8359376/v1","editorialEvents":[{"type":"communityComments","content":0},{"type":"editorInvitedReview","content":"","date":"2026-01-28T05:47:32+00:00","index":"hide","fulltext":""},{"type":"reviewerAgreed","content":"93245479445196665333490064091311657561","date":"2026-01-18T16:20:31+00:00","index":"hide","fulltext":""},{"type":"reviewerAgreed","content":"261085120995376369808281566644812243869","date":"2026-01-15T22:16:05+00:00","index":"hide","fulltext":""},{"type":"reviewersInvited","content":"","date":"2026-01-13T10:34:26+00:00","index":"","fulltext":""},{"type":"editorAssigned","content":"","date":"2026-01-13T03:11:20+00:00","index":"","fulltext":""},{"type":"editorInvited","content":"","date":"2025-12-23T13:02:39+00:00","index":"","fulltext":""},{"type":"checksComplete","content":"","date":"2025-12-22T19:48:15+00:00","index":"","fulltext":""},{"type":"submitted","content":"BMC Gastroenterology","date":"2025-12-22T19:43:20+00:00","index":"","fulltext":""}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"bmc-gastroenterology","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"bmge","sideBox":"Learn more about [BMC Gastroenterology](http://bmcgastroenterol.biomedcentral.com/)","snPcode":"","submissionUrl":"https://www.editorialmanager.com/bmge/default.aspx","title":"BMC Gastroenterology","twitterHandle":"BMC_series","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"em","reportingPortfolio":"BMC Series","inReviewEnabled":true,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"fc3ea9da-e8b7-4482-8b54-c909998bd638","owner":[],"postedDate":"January 16th, 2026","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"under-review","subjectAreas":[],"tags":[],"updatedAt":"2026-01-16T19:39:05+00:00","versionOfRecord":[],"versionCreatedAt":"2026-01-16 19:39:05","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-8359376","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-8359376","identity":"rs-8359376","version":["v1"]},"buildId":"XKTyCvWXoU3ODBz1xrDgd","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}