Treatment of Endometriosis and Other Gynecologic Conditions with Large Doses of Estrogens

HURXTHAL LM, Lewis M. Hurxthal, L M HURXTHAL, Anne T. Smith, A T SMITH, SMITH AT
New England Journal of Medicine · 1952 · vol. 247(10) , pp. 339–343 · doi:10.1056/nejm195209042471001 · PMID:14957228 · W2340584868
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⚙ AI-generated summary by claude@2026-06, 2026-06-12 ⓘ

This report details further experience with stilbestrol treatment for endometriosis and other gynecologic conditions, including one patient with verified endometriosis remaining amenorrheic and symptom-free after five years.

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Abstract

THE use of stilbestrol in the treatment of endometriosis was described in 1948 by Karnaky1 and Hurxthal and Arnold.2 The purpose of this report is to relate further experience with the use of this drug in the treatment of endometriosis and in a few other conditions.In their original communication, Hurxthal and Arnold2 described 3 cases in which stilbestrol was tolerated with favorable results. The first patient in whom endometriosis was verified remains well and is amenorrheic after treatment for five years. Nodules cannot be palpated on pelvic examination. On several occasions, the drug has been discontinued, and painful menstruation . . .

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Condition tags

endometriosis

MeSH descriptors

Contraceptive Agents, Female Diethylstilbestrol Endometriosis Estrogens Genital Diseases, Female Diethylstilbestrol Female Genital Diseases, Female Humans

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (14)

Cited by (8)

Source provenance

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License: CC0 · commercial use OK