Novel Synthesis of New Triazine Sulfonamides with Antitumor, Antimicrobial and Anti-SARS-CoV-2 Activities

Novel Synthesis of New Triazine Sulfonamides with Antitumor, Antimicrobial and Anti-SARS-CoV-2 Activities | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Novel Synthesis of New Triazine Sulfonamides with Antitumor, Antimicrobial and Anti-SARS-CoV-2 Activities Reham A. Mohamed-Ezzat, galal elgemeie This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-3862708/v1 This work is licensed under a CC BY 4.0 License Status: Published Journal Publication published 26 Mar, 2024 Read the published version in BMC Chemistry → Version 1 posted 8 You are reading this latest preprint version Abstract Novel approach for synthesizing triazine sulfonamide derivatives is accomplished via reacting the sulfaguanidine derivatives with N-cyanodithioiminocarbonate. Further reaction of the novel triazine sulfonamide analogues were reacted with various secondary amines, anilines and 2-aminothiazole to generate various substituted triazine sulfonamide analogues of promising broad spectrum activities. The in vitro anti-proliferative activities of most of the novel compounds were evaluated on the NCI-60 cell line panel. The antifungal and antibacterial activities of the compounds were also estimated. The antiviral activity against SARS COV-2 virus was performed to evaluate the half-maximal cytotoxic concentration (CC50) and inhibitory concentration 50 (IC50) of a representative compound from the novel triazine sulfonamide category. Anti-Microbial anti-proliferative SARS-CoV-2 triazines sulfonamides Synthesis. Full Text Additional Declarations No competing interests reported. Supplementary Files SupplementaryInformation4.docx Cite Share Download PDF Status: Published Journal Publication published 26 Mar, 2024 Read the published version in BMC Chemistry → Version 1 posted Editorial decision: Revision requested 02 Feb, 2024 Reviews received at journal 25 Jan, 2024 Reviewers agreed at journal 19 Jan, 2024 Reviewers invited by journal 19 Jan, 2024 Editor invited by journal 19 Jan, 2024 Editor assigned by journal 19 Jan, 2024 Submission checks completed at journal 19 Jan, 2024 First submitted to journal 14 Jan, 2024 You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-3862708","acceptedTermsAndConditions":true,"allowDirectSubmit":false,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":268364636,"identity":"8c2158d8-9d49-46ad-9cf3-1cba948bef03","order_by":0,"name":"Reham A. 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