Additional file 1 of Diving deep into uterine layers: ADC and IVIM at 0.55-T MRI

Additional File 1: Fig S1: Violin plots of diffusion parameters apparent diffusion coefficient (ADC), diffusivity (D) and pseudo-diffusivity (D*) and perfusion fraction (f) across the three cohorts for all three uterine layers. The central white line indicates the mean value, while the width of the plot reflects the distribution density of participants within that value range. Fig S2: Anterior-Posterior analysis of the myometrium and junctional zone for three participants groups showing the apparent diffusion coefficient (ADC), diffusivity (D) and perfusion fraction (f). *p < 0.05 compared with healthy controls and †p < 0.05 compared with participants with adenomyosis. Fig S3: Plots showing ADC and IVIM parameter variations in adenomyosis cases categorized according to MRI-based adenomyosis classification. The “Other” category includes cases that could not be assigned to a specific MRI subtype but demonstrated imaging features consistent with adenomyosis. Fig S4: Bland–Altman plots to evaluate the robustness of diffusion quantification for each uterine layer and diffusion parameter across cohorts between the repeated scans. The bold line represents the mean difference, and the dotted lines indicate the 95% limits of agreement (±1.96 standard deviations). Fig S5: IVIM model fitting and stability before and after motion correction registration, showing fitted curves in comparison with the measured averaged diffusion signal across the cohort. Derived parameters, diffusivity (D), pseudo-diffusivity (D*), perfusion fraction (f) and corresponding R² values are provided for each case. Table S1 Mean Diffusion and IVIM parameter values (Hormonal contraceptive users). Table S2 Inter-annotator and Intra-annotator variability of ADC and IVIM parameters. Table S3 Percentage of Variability in ADC and IVIM Metrics.