Edessy Stem Cell Score (ESS) Endometrium-Endometrioma

2 Abstract: This study aimed to evaluate stem cell expression (SCE) in endometriotic (E) and non endometriotic ovarian and endometrial tissues. This study was conducted on 40 women at Al-Azhar University Hospitals, Cairo, Egypt. The studied women were divided into two equal groups, group 1 with ovarian endometripoma and group 2 with normal ovary. Ovarian and endometrial samples were evaluated by hematoxlin & eosin for histopathology (HP) and of oct-4 for immunohistochemistry (IH) for SCE. Evaluation of IH parameters revealed that the most important factors for evaluating SC were arranged as score (Edessy Stem Cell Score=ESS). ESS of 5 was found to be a cut off point above which SCE showed significant increase. ESS was found to increase as we go from Pill pattern atrophic endometrium (PAE) to Secretory endometrium (SE) to disordered proliferative endometrium (DPE) to Simple endometrial hyperplasia (SEH). Endometrioma showed significant increase of ESS than that of the non endometriomal ovary. Also there was a statistically significant increase of the SCE of the endometriotic than that of the normal endometrium. It could be concluded that SCE was found to be of highly significant increase in endometriotic than non endometriotic tissue. ESS was found to be a practical evaluator of the SCE. The cut off point of ESS is 5 above which SCE showed significant statistical increase.