Long term effects of IUD on the human endometrium. Histologic, histochemical and ultrastructural studies.

Lee YB, Kim CS, Ro JY, Kwak HM, Song CH
Yonsei medical journal · 1983 · doi:10.3349/ymj.1983.24.2.141 · PMID:6679680
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Histologic, histochemical, and ultrastructural analyses of endometrial biopsies reveal that while IUDs cause only mild alterations, inflammatory reactions and asynchronous endometrial maturation may contribute to their contraceptive mechanism.

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This study evaluated the long-term histologic, histochemical, and ultrastructural effects of intrauterine devices on the human endometrium by analyzing biopsies from 178 IUD users and 44 controls. While most alterations such as hemorrhage or hyperplasia were infrequent or insignificant, the research identified a consistent inflammatory reaction and delayed endometrial maturation in the majority of users. The authors concluded that these mild changes, particularly the inflammatory response and asynchronous maturation, likely contribute to the contraceptive mechanism without causing major structural damage. This paper is centrally about the human endometrium but does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.

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Published online Feb 20, 2002. https://doi.org/10.3349/ymj.1983.24.2.141 Long Term Effects of IUD on the Human Endometrium - Histologic, Histochemical and Ultrastructural Studies - Abstract To evaluate the long term effects of an IUD on the human endometrium and find the possible contraceptive mechanism of IUD, histologic, histochemical and ultrastructural studies of human endometrial biopsies from 44 normal controls and 178 IUD wearers were made. Histologic findings included interstitial hemorrhage, inflammatory reaction, hyperplasia, atrophy, focal necrosis and squamous metaplasia. However, all of these findings were either infreqnent or insignificant except for inflammatory reaction. Histochemica1, enzymatic and ultrastructural findings were a1so unremarkable. The most significant finding, was asynchronism between cyclic dating and endometrial histologic dating, showing delayed endometrial maturation in the majority of IUD users. In summary, IUD insertion brings about mild and little histologic alteration in the human endometrium, but the inflammatory reaction and asynchronous endometrial matruation may play some role in the antifertility actifertility action of an IUD.

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