Matrix metalloproteinases-2 and -9 in cervical cancer: different roles in tumor progression

Marita Rauvala, M Rauvala, K Aglund, Kristina Aglund, Ulla Puistola, U Puistola, Taina Turpeenniemi‐Hujanen, T Turpeenniemi-Hujanen, G Horvath, G. Horváth, Roger Wïllén, R Willén, U Stendahl
International Journal of Gynecological Cancer · 2006 · vol. 16(3) , pp. 1297–1302 · doi:10.1111/j.1525-1438.2006.00448.x · PMID:16803520 · W2151773547
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This study analyzed cervical cancer tissues to determine that MMP-2 overexpression predicts unfavorable survival and correlates with aggressive behavior, while MMP-9 expression diminishes in high-grade tumors, indicating distinct roles for these enzymes.

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Abstract

The incidence of uterine cervical cancer has increased slightly in Western countries, with an increase in relatively young women. Overexpression of matrix metalloproteinases (MMPs)-2 and -9 has turned out as a prognostic factor in many cancers. We compared the expression of the proteins MMP-2 and MMP-9 in cervical primary tumors with clinical outcome and risk factors of cervical cancer. One hundred sixty-one patients with cervical cancer treated in Umeå University Hospital or Sahlgrenska University Hospital, Sweden, between 1991 and 1995 were included in the study. Paraffin-embedded tissue samples obtained prior to treatment were examined immunohistochemically by specific antibodies for MMP-2 and MMP-9. Forty-two percent of the tumors were intensively positive for MMP-2 and 31% for MMP-9. Nineteen percent of the samples were intensively positive for both proteinases and 47% negative or weak for both. Overexpression of MMP-2 seemed to predict unfavorable survival under Kaplan-Meier analysis and in the multivariate analysis. Early sexual activity and low parity seemed to correlate to overexpression of MMP-2. MMP-9 was not associated with survival or sexual behavior. Intensive MMP-9 was noted in grade 1 tumors. We conclude that MMP-2 and MMP-9 have different roles in uterine cervical cancer. MMP-2 could be associated with aggressive behavior, but MMP-9 expression diminishes in high-grade tumors.

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MeSH descriptors

Carcinoma Matrix Metalloproteinase 2 Matrix Metalloproteinase 9 Uterine Cervical Neoplasms Adult Aged Aged, 80 and over Carcinoma Carcinoma Contraceptive Agents, Female Contraceptive Agents, Female Disease Progression Female Humans Matrix Metalloproteinase 2 Matrix Metalloproteinase 9 Middle Aged Parity Pregnancy Retrospective Studies

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