Evaluation of Prescribing Adherence to Guideline-Directed Medical Therapy in Patients with Chronic Heart Failure. A Retrospective Study at The National Heart Centre in Oman

Evaluation of Prescribing Adherence to Guideline-Directed Medical Therapy in Patients with Chronic Heart Failure. A Retrospective Study at The National Heart Centre in Oman | Authorea try { document.documentElement.classList.add('js'); } catch (e) { } var _gaq = _gaq || []; _gaq.push(['_setAccount', 'G-8VDV14Y67G']); _gaq.push(['_trackPageview']); (function() { var ga = document.createElement('script'); ga.type = 'text/javascript'; ga.async = true; ga.src = ('https:' == document.location.protocol ? 'https://ssl' : 'http://www') + '.google-analytics.com/ga.js'; var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(ga, s); })(); Skip to main content Preprints Collections Wiley Open Research IET Open Research Ecological Society of Japan All Collections About About Authorea FAQs Contact Us Quick Search anywhere Search for preprint articles, keywords, etc. Search Search ADVANCED SEARCH SCROLL This is a preprint and has not been peer reviewed. Data may be preliminary. 12 February 2025 V1 Latest version Share on Evaluation of Prescribing Adherence to Guideline-Directed Medical Therapy in Patients with Chronic Heart Failure. A Retrospective Study at The National Heart Centre in Oman Authors : Manal Abdullah Albalushi 0009-0001-4353-0314 [email protected] , Leila Neshat-Mokadem , and Ghalib Almawaali Authors Info & Affiliations https://doi.org/10.22541/au.173936901.15092718/v1 Published BMC Cardiovascular Disorders Version of record Peer review timeline 222 views 113 downloads Contents Abstract Supplementary Material Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Purpose: Guidelines-directed medical therapy (GDMT) may benefit patients with heart failure (HF) reduced ejection fraction ((HFrEF, ≤40%), however, there are significant gaps between guidelines and real-world practices. The aim of this study was to evaluated prescribing adherence to the recommended GDMT in HFrEF patients using the global guideline adherence score. Method: A retrospective study among HFrEF patients at the National Heart Centre in Muscat, Oman, was conducted between 1st January and 30th June 2022. The optimum target doses were identified according to the 2021 European Society of Cardiology HF guidelines. Thus, for eligible patients, prescribing all indicated GDMT in doses ≥50% of the target dose is considered good adherence; the use of more than half of the medications in doses ≥50% of the target dose, moderate adherence; and the use of less than half the recommended medications and/or in doses <50% of target dose, poor adherence. Univariate statistics were used for the analysis. Results: The overall mean age of the cohort was 57 ±13.6 years with a predominance of male patients (70%; n=180). The overall prescribing adherence to guideline-recommended HF medications was 71% good, 22% moderate, and 7% poor. There was a significate association between the sub-optimal dose of GDMT and patients with hypertension (P=0.004), dilated cardiomyopathy (P=0.015), older age (P=0.004) and chronic kidney disease (P=0.001). Conclusion: Prescribing adherence to recommended GDMT in Oman is similar to that of international studies. Furthermore, sub-optimal GDMT titration was significantly associated with older age and comorbidity, suggesting that frailty perception may have an impact on GDMT titration. Supplementary Material File (pds-25-0101-file001.docx) Download 86.63 KB Information & Authors Information Version history V1 Version 1 12 February 2025 Peer review timeline Published BMC Cardiovascular Disorders Version of Record 24 Oct 2025 Published Copyright This work is licensed under a Non Exclusive No Reuse License. Keywords gdmt guideline adherence guideline-directed medical therapy heart failure oman prescribing Authors Affiliations Manal Abdullah Albalushi 0009-0001-4353-0314 [email protected] The Royal Hospital View all articles by this author Leila Neshat-Mokadem Robert Gordon University School of Nursing Midwifery and Paramedic Practice View all articles by this author Ghalib Almawaali The Royal Hospital View all articles by this author Metrics & Citations Metrics Article Usage 222 views 113 downloads .FvxKWukQNSOunydq8rnd { width: 100px; } Citations Download citation Manal Abdullah Albalushi, Leila Neshat-Mokadem, Ghalib Almawaali. Evaluation of Prescribing Adherence to Guideline-Directed Medical Therapy in Patients with Chronic Heart Failure. A Retrospective Study at The National Heart Centre in Oman. Authorea . 12 February 2025. DOI: https://doi.org/10.22541/au.173936901.15092718/v1 If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download. For more information or tips please see 'Downloading to a citation manager' in the Help menu . Format Please select one from the list RIS (ProCite, Reference Manager) EndNote BibTex Medlars RefWorks Direct import Tips for downloading citations document.getElementById('citMgrHelpLink').addEventListener('click', function() { popupHelp(this.href); return false; }); $(".js__slcInclude").on("change", function(e){ if ($(this).val() == 'refworks') $('#direct').prop("checked", false); $('#direct').prop("disabled", ($(this).val() == 'refworks')); }); View Options View options PDF View PDF Figures Tables Media Share Share Share article link Copy Link Copied! Copying failed. 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